Implications of micro-RNA profiling for cancer diagnosis

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

The functions of animal microRNAs

2004 • 10,392 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Oncomirs — microRNAs with a role in cancer

2006 • 6,877 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer

2005 • 5,199 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Real-time quantification of microRNAs by stem-loop RT-PCR

2005 • 4,707 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

2006 • 3,029 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

2005 • 2,391 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

Multiclass cancer diagnosis using tumor gene expression signatures

2001 • 2,021 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

2005 • 1,504 citations

MicroRNAs in cell proliferation, cell death, and tumorigenesis

2006 • 1,367 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

miRNAs, Cancer, and Stem Cell Division

2005 • 1,313 citations

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

2004 • 1,306 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

The role of microRNA genes in papillary thyroid carcinoma

2005 • 1,217 citations

Vertebrate MicroRNA Genes

2003 • 1,190 citations

Extensive modulation of a set of microRNAs in primary glioblastoma

2005 • 1,090 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

Human embryonic stem cells express a unique set of microRNAs

2004 • 960 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

2004 • 942 citations

The colorectal microRNAome

2006 • 934 citations

New microRNAs from mouse and human

2003 • 881 citations

How microRNAs control cell division, differentiation and death

2005 • 808 citations

Heterochronic Mutants of the Nematode Caenorhabditis elegans

1984 • 792 citations

Characterization of Dicer-deficient murine embryonic stem cells

2005 • 763 citations

A custom microarray platform for analysis of microRNA gene expression

2004 • 733 citations

BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

2005 • 676 citations

Facile Means for Quantifying Microrna Expression by Real-Time PCR

2005 • 674 citations

Epidermal Growth Factor Receptor Mutations, Small-Molecule Kinase Inhibitors, and Non–Small-Cell Lung Cancer: Current Knowledge and Future Directions

2005 • 636 citations

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

2004 • 623 citations

Aberrant T cell differentiation in the absence of Dicer

2005 • 620 citations

Microarray-based, high-throughput gene expression profiling of microRNAs

2004 • 618 citations

MicroRNA Biogenesis and Cancer

2005 • 613 citations

In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes

2005 • 584 citations

Sequence-Specific Inhibition of Small RNA Function

2004 • 577 citations

MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues

2004 • 557 citations

MicroRNA deregulation in human thyroid papillary carcinomas

2006 • 525 citations

A high-throughput method to monitor the expression of microRNA precursors

2004 • 475 citations

MicroRNAs and cancer

2003 • 443 citations

MicroRNAs: Critical Regulators of Development, Cellular Physiology and Malignancy

2005 • 425 citations

Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs

2005 • 424 citations

MicroRNAs and the regulation of cell death

2004 • 415 citations

MicroRNAs as oncogenes

2005 • 412 citations

Probing microRNAs with microarrays: Tissue specificity and functional inference

2004 • 375 citations

miR‐15a and miR‐16‐1 down‐regulation in pituitary adenomas

2005 • 351 citations

Depletion of Human Micro-RNA miR-125b Reveals That It Is Critical for the Proliferation of Differentiated Cells but Not for the Down-regulation of Putative Targets during Differentiation

2005 • 336 citations

An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe

2005 • 325 citations

A single-molecule method for the quantitation of microRNA gene expression

2005 • 280 citations

Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation

2004 • 272 citations

The Race for the $1000 Genome

2006 • 263 citations

An optimized isolation and labeling platform for accurate microRNA expression profiling

2005 • 262 citations

Sizing up miRNAs as cancer genes

2005 • 198 citations

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

2004 • 164 citations

Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells

2004 • 154 citations

Genomics of Chronic Lymphocytic Leukemia MicroRNAs as New Players With Clinical Significance

2006 • 151 citations

Micrornas As A Potential Magic Bullet In Cancer

2006 • 84 citations

Oncogenes Come of Age

2005 • 34 citations

New perspectives on neoplasia and the RNA world

2005 • 29 citations

Slowing Down the Ras Lane: miRNAs as Tumor Suppressors?

2005 • 28 citations

Improving survival in metastatic carcinoma of unknown origin

1999 • 7 citations