Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

The detection of disease clustering and a generalized regression approach.

1967 • 11,489 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Prediction of central nervous system embryonal tumour outcome based on gene expression

2002 • 2,359 citations

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

2001 • 524 citations

Small molecule developmental screens reveal the logic and timing of vertebrate development

2000 • 483 citations

Profiling alternative splicing on fiber-optic arrays

2002 • 211 citations

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1999 • 200 citations

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1965 • 192 citations

Disruption of the estrogen receptor β gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis

2003 • 164 citations

Functional potencies of new antiparkinsonian drugs at recombinant human dopamine D1, D2 and D3 receptors

1999 • 158 citations

Induction of Differentiation of Human Promyelocytic Leukemia Cells (HL-60) by Nucleosides and Methotrexate

1981 • 120 citations

BADGE, BeadsArray for the Detection of Gene Expression, a High-Throughput Diagnostic Bioassay

2001 • 112 citations

A one-bead, one-stock solution approach to chemical genetics: part 2

2001 • 105 citations

Chemical complementation: A reaction-independent genetic assay for enzyme catalysis

2002 • 102 citations

In Vivo Activation of cAMP Signaling Induces Growth Arrest and Differentiation in Acute Promyelocytic Leukemia

2002 • 101 citations

Biological Mechanism Profiling Using an Annotated Compound Library

2003 • 96 citations

Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase.

1986 • 94 citations

Estradiol Inhibits Smooth Muscle Cell Growth in Part by Activating the cAMP-Adenosine Pathway

2000 • 65 citations

Multiplex gene expression analysis for high-throughput drug discovery: screening and analysis of compounds affecting genes overexpressed in cancer cells.

2002 • 63 citations

Mechanism of growth inhibition by methotrexate.

1975 • 39 citations

An overview of the FDA publication Approved Drug Products with Therapeutic Equivalence Evaluations.

1990 • 30 citations

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

2003 • 27 citations

D1 dopamine receptor activity of anti-Parkinsonian drugs

1997 • 24 citations

Estrone potentiates myeloid cell differentiation

1999 • 23 citations

Clinical and laboratory evaluation of all‐trans retinoic acid modulation of chemotherapy in patients with acute myelogenous leukaemia

2000 • 19 citations

Assay for Phagocytosis

1994 • 13 citations

Effects of dimaprit on growth and differentiation of human promyelocytic cell line, HL-60

1985 • 13 citations

Inhibition of Lymphocyte-Mediated Cytolysis and Cyclic amp Phosphodiesterase by<u>Erythro</u>-9–(2-Hydroxy-3-Nonyl)Adenine

1982 • 10 citations

c-myc Down-regulation in suramin-treated HL60 cells precedes growth inhibition but does not trigger differentiation.

1994 • 9 citations