Overexpression of HER2 (erbB2) in Human Breast Epithelial Cells Unmasks Transforming Growth Factor β-induced Cell Motility

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

2000 • 956 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.

2002 • 607 citations

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo.

2001 • 550 citations

Transforming growth factor production by chemically transformed cells.

1981 • 506 citations

A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.

1994 • 491 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 490 citations

Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

2003 • 433 citations

p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration

2002 • 431 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 406 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Integrin β1 Signaling Is Necessary for Transforming Growth Factor-β Activation of p38MAPK and Epithelial Plasticity

2001 • 381 citations

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.

1998 • 357 citations

A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.

1994 • 350 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase

1998 • 288 citations

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

2001 • 283 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Glucocorticoid Receptor-mediated Protection from Apoptosis Is Associated with Induction of the Serine/Threonine Survival Kinase Gene, sgk-1

2001 • 254 citations

Targeting the TGFβ signaling network in human neoplasia

2003 • 245 citations

Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells

2003 • 243 citations

Growth modulation of mouse keratinocytes by transforming growth factors.

1988 • 242 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells

2004 • 224 citations

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

1999 • 221 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

2003 • 192 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

2001 • 178 citations

Autocrine Transforming Growth Factor-β Signaling Mediates Smad-independent Motility in Human Cancer Cells

2003 • 157 citations

Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-β

2000 • 155 citations

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

2003 • 129 citations

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

1998 • 113 citations

The Quiescin Q6 Gene (QSCN6) Is a Fusion of Two Ancient Gene Families: Thioredoxin and ERV1

1998 • 101 citations

Interleukin-1 Family Expression in Human Breast Cancer: Interleukin-1 Receptor Antagonist

2000 • 88 citations

Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis.

1999 • 78 citations

Interaction in Vivo and in Vitro of the Metastasis-inducing S100 Protein, S100A4 (p9Ka) with S100A1

2000 • 76 citations

Transforming growth factor-?1 expression in cultured corneal fibroblasts in response to injury

2000 • 48 citations

Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines.

1998 • 44 citations

Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue.

2001 • 35 citations

Metallothionein isoform expression by breast cancer cells

2000 • 25 citations

Differential regulation of IL‐1 and IL‐1 receptor antagonist in HaCaT keratinocytes by tumor necrosis factor‐α and transforming growth factor‐β1

1996 • 14 citations

Disruption of transforming growth factor ?-regulated laminin receptor function by expression of antisense laminin, a chain RNA in human colon cancer cells

2000 • 6 citations