Seeing Within

Inflammation in atherosclerosis

2002 • 7,873 citations

Bone marrow cells regenerate infarcted myocardium

2001 • 5,234 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2003 • 4,348 citations

Atherosclerosis

2001 • 2,982 citations

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

2001 • 2,583 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

2002 • 2,231 citations

Molecular imaging in living subjects: seeing fundamental biological processes in a new light

2003 • 2,194 citations

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

2001 • 2,133 citations

Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

2002 • 2,094 citations

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

2001 • 1,999 citations

Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer

2003 • 1,965 citations

Shedding light onto live molecular targets

2003 • 1,859 citations

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

2002 • 1,781 citations

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

2000 • 1,723 citations

Molecular imaging of cancer with positron emission tomography

2002 • 1,599 citations

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

1999 • 1,578 citations

Platelets in atherothrombosis

2002 • 1,533 citations

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

2003 • 1,507 citations

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

2002 • 1,460 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1996 • 1,446 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Molecular Imaging

2001 • 1,248 citations

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

2001 • 1,153 citations

In vivo visualization of gene expression using magnetic resonance imaging

2000 • 1,143 citations

Prognostic Value of Myeloperoxidase in Patients with Chest Pain

2003 • 1,049 citations

Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells

2001 • 1,034 citations

Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.

1990 • 1,017 citations

Magnetic relaxation switches capable of sensing molecular interactions

2002 • 882 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

A Critical Role of Platelet Adhesion in the Initiation of Atherosclerotic Lesion Formation

2002 • 847 citations

Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells

1998 • 820 citations

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

2000 • 808 citations

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

2000 • 797 citations

Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging

2003 • 794 citations

Molecular imaging in drug discovery and development

2003 • 793 citations

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1999 • 790 citations

In vivo magnetic resonance imaging of transgene expression

2000 • 785 citations

In vivo molecular target assessment of matrix metalloproteinase inhibition

2001 • 730 citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

2003 • 718 citations

In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction

2003 • 717 citations

Scaling down imaging: molecular mapping of cancer in mice

2002 • 703 citations

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

2003 • 695 citations

The macrophage foam cell as a target for therapeutic intervention

2002 • 684 citations

Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic Rabbits

2001 • 602 citations

Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination

1999 • 539 citations

Visualizing Gene Expression in Living Mammals Using a Bioluminescent Reporter

1997 • 530 citations

Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands

2001 • 523 citations

Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent

2001 • 522 citations

Novel MRI Contrast Agent for Molecular Imaging of Fibrin

2001 • 518 citations

Apoptosis and Heart Failure

2000 • 512 citations

Viral-Induced Self-Assembly of Magnetic Nanoparticles Allows the Detection of Viral Particles in Biological Media

2003 • 510 citations

A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure

2000 • 470 citations

Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells

2003 • 466 citations

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography

1999 • 459 citations

A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography

2000 • 451 citations

Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to α _v β ₃

2003 • 451 citations

Ultrasound Assessment of Inflammation and Renal Tissue Injury With Microbubbles Targeted to P-Selectin

2001 • 439 citations

Visualisation of cell death in vivo in patients with acute myocardial infarction

2000 • 439 citations

A Novel Site-Targeted Ultrasonic Contrast Agent With Broad Biomedical Application

1996 • 413 citations

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences

2001 • 376 citations

Imaging of light emission from the expression of luciferases in living cells and organisms: a review

2002 • 372 citations

In vivo near-infrared fluorescence imaging of osteoblastic activity

2001 • 371 citations

In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors.

2003 • 359 citations

In vivo imaging of proteolytic enzyme activity using a novel molecular reporter.

2000 • 354 citations

In Vivo Imaging of Proteolytic Activity in Atherosclerosis

2002 • 354 citations

DNA-Based Magnetic Nanoparticle Assembly Acts as a Magnetic Relaxation Nanoswitch Allowing Screening of DNA-Cleaving Agents

2002 • 354 citations

Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms

2002 • 347 citations

Stem Cells for Myocardial Regeneration

2002 • 343 citations

Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to α _v -Integrins

2003 • 339 citations

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.

1996 • 333 citations

Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.

1996 • 329 citations

Annexin-V imaging for noninvasive detection of cardiac allograft rejection

2001 • 325 citations

Differential Conjugation of Tat Peptide to Superparamagnetic Nanoparticles and Its Effect on Cellular Uptake

2002 • 321 citations

Novel Receptor-Targeted Fluorescent Contrast Agents for In Vivo Tumor Imaging

2000 • 315 citations

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

1995 • 309 citations

Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform

1997 • 289 citations

Molecular Imaging of Cardiac Cell Transplantation in Living Animals Using Optical Bioluminescence and Positron Emission Tomography

2003 • 288 citations

Noninvasive Ultrasound Imaging of Inflammation Using Microbubbles Targeted to Activated Leukocytes

2000 • 286 citations

Use of Positron Emission Tomography in Animal Research

2001 • 280 citations

Disruption of the myocardial extracellular matrix leads to cardiac dysfunction

2000 • 277 citations

Tracking Transplanted Stem Cell Migration Using Bifunctional, Contrast Agent-Enhanced, Magnetic Resonance Imaging

2002 • 264 citations

It's not just about anatomy: In vivo bioluminescence imaging as an eyepiece into biology

2002 • 260 citations

Noninvasive real-time imaging of apoptosis

2002 • 244 citations

Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters

2001 • 233 citations

Superparamagnetic Iron Oxide–Enhanced MRI of Atherosclerotic Plaques in Watanabe Hereditable Hyperlipidemic Rabbits

2000 • 231 citations

Targeted imaging using ultrasound

2002 • 230 citations

Magnetic Sensors for Protease Assays

2003 • 225 citations

Magnetic Resonance Imaging of Inducible E-Selectin Expression in Human Endothelial Cell Culture

2001 • 218 citations

In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement

1999 • 217 citations

Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart

2001 • 212 citations

Magnetic resonance imaging of atherosclerotic plaques using superparamagnetic iron oxide particles

2001 • 212 citations

Near-infrared fluorescent imaging of tumor apoptosis.

2003 • 205 citations

MR imaging and scintigraphy of gene expression through melanin induction.

1997 • 190 citations

PET imaging of somatostatin receptors: design, synthesis and preclinical evaluation of a novel 18 F-labelled, carbohydrated analogue of octreotide

2003 • 179 citations

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function

2001 • 166 citations

Noninvasive Imaging of Myocardial Reperfusion Injury Using Leukocyte-Targeted Contrast Echocardiography

2002 • 164 citations

Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.

2002 • 162 citations

Technicolour transgenics: imaging tools for functional genomics in the mouse

2003 • 162 citations

Molecular-genetic imaging: current and future perspectives

2003 • 155 citations

Macrophage Accumulation Associated With Rat Cardiac Allograft Rejection Detected by Magnetic Resonance Imaging With Ultrasmall Superparamagnetic Iron Oxide Particles

2001 • 155 citations

Annexin V–CLIO: A Nanoparticle for Detecting Apoptosis by MRI

2002 • 153 citations

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy

1999 • 152 citations

A review of high-resolution X-ray computed tomography and other imaging modalities for small animal research.

2001 • 152 citations

Novel Tat-Peptide Chelates for Direct Transduction of Technetium-99m and Rhenium into Human Cells for Imaging and Radiotherapy

2000 • 148 citations

Acute myocardial infarct imaging with indium-111-labeled monoclonal antimyosin Fab.

1987 • 145 citations

Oligomerization of Paramagnetic Substrates Result in Signal Amplification and can be Used for MR Imaging of Molecular Targets

2002 • 141 citations

Mitochondria in apoptosis of ischemic heart

2003 • 141 citations

Optical Imaging of Cardiac Reporter Gene Expression in Living Rats

2002 • 141 citations

Myocardial matrix metalloproteinase(s): localization and activation

1993 • 139 citations

Molecular imaging of gene expression and protein function in vivo with PET and SPECT

2002 • 137 citations

Peroxidase Substrate Nanosensors for MR Imaging

2003 • 136 citations

Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo

2003 • 132 citations

In Vivo Imaging of Thrombin Activity in Experimental Thrombi With Thrombin-Sensitive Near-Infrared Molecular Probe

2002 • 131 citations

Challenges in Small Animal Noninvasive Imaging

2001 • 128 citations

Enhanced Tumor Detection Using a Folate Receptor-Targeted Near-Infrared Fluorochrome Conjugate

2003 • 128 citations

Optical Imaging of Apoptosis as a Biomarker of Tumor Response to Chemotherapy

2003 • 122 citations

Superparamagnetic Iron Oxide–Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo

2003 • 121 citations

MRI of Transgene Expression: Correlation to Therapeutic Gene Expression

2002 • 113 citations

A targeted contrast agent for magnetic resonance imaging of thrombus: Implications of spatial resolution

2001 • 110 citations

In Vivo Molecular Imaging of Stretch-Induced Tissue Factor in Carotid Arteries with Ligand-Targeted Nanoparticles

2000 • 109 citations

Positron-Emission Tomography Reporter Gene Expression Imaging in Rat Myocardium

2003 • 103 citations

Antibodies with infinite affinity

2001 • 99 citations

Imaging Transgenic Animals

1999 • 98 citations

Nuclear medicine applications in molecular imaging

2002 • 90 citations

Size Optimization of Synthetic Graft Copolymers for in Vivo Angiogenesis Imaging

2001 • 86 citations

A Novel Near-Infrared Fluorescence Sensor for Detection of Thrombin Activation in Blood

2002 • 83 citations

Novel Factor XIII Probes for Blood Coagulation Imaging

2003 • 77 citations

Enhanced Visualization of Intravascular and Left Atrial Appendage Thrombus with the Use of a Thrombus-Targeting Ultrasonographic Contrast Agent (MRX-408A1): In Vivo Experimental Echocardiographic Studies

1999 • 77 citations

The Contribution of Activated Factor XIII to Fibrinolytic Resistance in Experimental Pulmonary Embolism

1999 • 74 citations

99mTc-labeled divalent and tetravalent CC49 single-chain Fv's: novel imaging agents for rapid in vivo localization of human colon carcinoma.

2001 • 71 citations

Imaging Characteristics of a Novel Technetium Tc 99m–Labeled Platelet Glycoprotein IIb/IIIa Receptor Antagonist in Patients With Acute Deep Vein Thrombosis or a History of Deep Vein Thrombosis

2003 • 70 citations

Iron-Oxide-Enhanced Magnetic Resonance Imaging of Atherosclerotic Plaques

2002 • 68 citations

Catalytic Life of Activated Factor XIII in Thrombi

2000 • 63 citations

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.

1997 • 44 citations

Proteolytic degradation of low density lipoproteins by arterial smooth muscle cells

1981 • 40 citations

In Vivo Imaging of HIV Protease Activity in Amplicon Vector-transduced Gliomas

2004 • 40 citations

The current role of infarct avid imaging

1999 • 30 citations

Chemical synthesis of firefly luciferin analogs and inhibitors

2000 • 28 citations

Oncogenes, cancer and imaging.

1999 • 22 citations

Radiolabeled peptide ligands for imaging thrombi and emboli

2001 • 18 citations

MAGNETIC NANOSENSORS FOR DNA ANALYSIS

2002 • 3 citations