Optical Imaging of Apoptosis as a Biomarker of Tumor Response to Chemotherapy

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

1999 • 1,578 citations

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

1998 • 724 citations

In vivo detection and imaging of phosphatidylserine expression during programmed cell death

1998 • 542 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

Apoptotic cell removal

2001 • 472 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

Near-Infrared Optical Imaging of Protease Activity for Tumor Detection

1999 • 311 citations

Apoptosis and cancer chemotherapy

2001 • 296 citations

Cancer therapy and p53

1995 • 194 citations

Annexin V Staining Due to Loss of Membrane Asymmetry Can Be Reversible and Precede Commitment to Apoptotic Death

1999 • 194 citations

Would near-infrared fluorescence signals propagate through large human organs for clinical studies?

2002 • 166 citations

Chemotherapy-Induced Apoptosis

1997 • 155 citations

Formation of Two-dimensional Arrays of Annexin V on Phosphatidylserine-containing Liposomes

1994 • 144 citations

In Vivo Tomographic Imaging of Near-Infrared Fluorescent Probes

2002 • 137 citations

Detection of apoptosis in live cells by MitoTracker? Red CMXRos and SYTO dye flow cytometry

1997 • 122 citations

Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis

1999 • 117 citations

Apoptosis and cancer chemotherapy

2001 • 94 citations

Annexin V Interaction with Phosphatidylserine-Containing Vesicles at Low and Neutral pH

1997 • 93 citations

Monitoring Apoptosis in Real Time

2002 • 88 citations

The dynamic process of apoptosis analyzed by flow cytometry using Annexin‐V/propidium iodide and a modified in situ end labeling technique

2001 • 87 citations

Diffuse optical tomography of highly heterogeneous media

2001 • 74 citations

New insights into the mechanism for clearance of apoptotic cells

2000 • 72 citations

Apoptosis and chemoresistance in transgenic cancer models

2001 • 72 citations

Imaging cyclophosphamide-induced intramedullary apoptosis in rats using 99mTc-radiolabeled annexin V.

2001 • 65 citations

Detection of early gastric cancer by a real-time autofluorescence imaging system

2001 • 65 citations

Preparation and Characterization of an Endogenously Fluorescent Annexin for Detection of Apoptotic Cells

1998 • 57 citations

Increased cell surface exposure of phosphatidylserine on propidium iodide negative thymocytes undergoing death by necrosis

1999 • 55 citations

Fluorescein electronic endoscopy: A novel method for detection of early stage gastric cancer not evident to routine endoscopy

2002 • 32 citations

PATHWAYS OF APOPTOSIS AND THE MODULATION OF CELL DEATH IN CANCER

2001 • 24 citations

In Vivo Tomographic Imaging of Near-Infrared Fluorescent Probes

2002 • 21 citations