Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

A family of embedded Runge-Kutta formulae

1980 • 3,203 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1996 • 2,325 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Imaging the expression of transfected genes in vivo.

1995 • 391 citations

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

1998 • 374 citations

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.

1996 • 333 citations

Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.

1998 • 303 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts.

1999 • 175 citations

Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits.

1990 • 129 citations

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

1999 • 121 citations

Phase I Study of Direct Administration of a Replication Deficient Adenovirus Vector Containing theE. coliCytosine Deaminase Gene to Metastatic Colon Carcinoma of the Liver in Association with the Oral Administration of the Pro-Drug 5-Fluorocytosine. The New York Hospital-Cornell Medical Center, New York, NY

1997 • 120 citations

Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine.

1996 • 100 citations

The Genetic Basis of Resistance to 5-Fluorocytosine inCandidaSpecies andCryptococcus Neoformans

1987 • 90 citations

The development of in vivo imaging systems to study gene expression

1998 • 88 citations

The Effect of Single versus Double-Strand Substitution on Halogenated Pyrimidine-Induced Radiosensitization and DNA Strand Breakage in Human Tumor Cells

1990 • 85 citations

Human tumor fluorouracil trapping: clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics.

1990 • 82 citations

The non-invasive monitoring of low dose, infusional 5-fluorouracil and its modulation by interferon-α using in vivo 19F magnetic resonance spectroscopy in patients with colorectal cancer: A pilot study

1993 • 66 citations

Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interferon-α

1996 • 59 citations

Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans

1997 • 58 citations

Non-invasive19F-NMRS of 5-fluorouracil in pharmacokinetics and pharmacodynamic studies

1998 • 58 citations

In vivo measurements of intratumoral metabolism, modulation, and pharmacokinetics of 5-fluorouracil, using 19F nuclear magnetic resonance spectroscopy.

1991 • 57 citations

¹⁹F MRS studies of fluoropyrimidine chemotherapy. A review

1989 • 53 citations

Transport of 5-fluorouracil and uracil into human erythrocytes

1993 • 52 citations

Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.

1998 • 52 citations

Drug monitoring of 5-fluorouracil: In vivo 19F NMR study during 5-FU chemotherapy in patients with metastases of colorectal adenocarcinoma

1994 • 48 citations

Intratumoral conversion of 5-fluorocytosine to 5-fluorouracil by monoclonal antibody-cytosine deaminase conjugates: noninvasive detection of prodrug activation by magnetic resonance spectroscopy and spectroscopic imaging.

1998 • 47 citations

Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study

1996 • 47 citations

The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer.

1992 • 47 citations

Regional Brain Measurement of B_max and K_D with the Opiate Antagonist Cyclofoxy: Equilibrium Studies in the Conscious Rat

1991 • 45 citations

In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues

1990 • 43 citations

Enhancement of hyperthermia effect in vivo by amiloride and dids

1993 • 42 citations

Baker's yeast cytosine deaminase. Enzymic properties and allosteric inhibition by nucleosides and nucleotides

1971 • 40 citations

Flucytosine conversion to fluorouracil in humans: Does a correlation with gut flora status exist? A report of two cases using fluorine-19 magnetic resonance spectroscopy

1991 • 28 citations

In Vitro and Ex Vivo Autoradiographic Studies of Nicotinic Acetylcholine Receptors Using [18F]Fluoronorchloroepibatidine in Rodent and Human Brain

1998 • 27 citations

Intra- and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging.

1998 • 27 citations

Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma

1986 • 27 citations

Dexamethasone effects on vascular volume and tissue hematocrit in experimental RG-2 gliomas and adjacent brain

1988 • 26 citations

Cloning, Overexpression, and Purification of Cytosine Deaminase fromSaccharomyces cerevisiae

1998 • 26 citations

19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism

1990 • 24 citations

¹⁹F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5‐fluorouracil by the uridine phosphorylase inhibitor 5‐benzylacyclouridine

1997 • 23 citations

Metabolism of 5-fluorouracil in various human normal and tumor tissues.

1981 • 22 citations

Intra-Hepatic Arterial Drug Delivery

1996 • 20 citations

Direct detection of intratumoral 5-fluorouracil trapping using metabolic 19F MR imaging

1999 • 20 citations

Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy

1996 • 17 citations

In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review

1992 • 16 citations

Study of the metabolism of flucytosine in Aspergillus species by 19F nuclear magnetic resonance spectroscopy

1989 • 15 citations

A 19F nuclear magnetic resonance study of uptake and metabolism of 5-fluorocytosine in susceptible and resistant strains of Candida albicans

1986 • 14 citations

Noninvasive and quantitative 19F nuclear magnetic resonance study of flucytosine metabolism in Candida strains

1986 • 14 citations