Imaging Transgenic Animals

Optical Coherence Tomography

1991 • 12,956 citations

Fundamentals of Photonics

2012 • 3,811 citations

Fundamentals of Photonics

1991 • 3,194 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Toward a quantitative assessment of diffusion anisotropy

1996 • 2,399 citations

In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography

1997 • 1,350 citations

FLASH imaging: Rapid NMR imaging using low flip-angle pulses

2011 • 1,140 citations

Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system.

1990 • 1,132 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

FLASH imaging. Rapid NMR imaging using low flip-angle pulses

1986 • 814 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Photonic detection of bacterial pathogens in living hosts

1995 • 655 citations

High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner

1998 • 624 citations

Transcription factor AP-2 essential for cranial closure and craniofacial development

1996 • 611 citations

MicroPET: a high resolution PET scanner for imaging small animals

1997 • 610 citations

Single photon-emission computed tomography

2010 • 580 citations

Optical Coherence Tomography for Optical Biopsy

1996 • 557 citations

Visualizing Gene Expression in Living Mammals Using a Bioluminescent Reporter

1997 • 530 citations

Ballistic 2-D Imaging Through Scattering Walls Using an Ultrafast Optical Kerr Gate

1991 • 520 citations

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography

1999 • 459 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 439 citations

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

1998 • 374 citations

Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging.

1999 • 338 citations

Magnetically labeled cells can be detected by MR imaging

1997 • 338 citations

Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity

1993 • 334 citations

A “Smart” Magnetic Resonance Imaging Agent That Reports on Specific Enzymatic Activity

1997 • 330 citations

NMR and its Applications to Living Systems

1996 • 296 citations

Structure of mitochondrial creatine kinase

1996 • 291 citations

Detection of Single Mammalian Cells by High-Resolution Magnetic Resonance Imaging

1999 • 266 citations

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

1998 • 262 citations

Initial results from the Sherbrooke avalanche photodiode positron tomograph

1996 • 262 citations

Altered Ca2+ Responses in Muscles with Combined Mitochondrial and Cytosolic Creatine Kinase Deficiencies

1997 • 250 citations

A high resolution animal PET scanner using compact PS-PMT detectors

1997 • 241 citations

MR Imaging of Anisotropically Restricted Diffusion of Water in the Nervous System

1991 • 230 citations

Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals

1998 • 224 citations

Time-resolved coherent and incoherent components of forward light scattering in random media

1990 • 217 citations

Pinhole SPECT: An approach to in vivo high resolution SPECT imaging in small laboratory animals

1994 • 207 citations

Ultra-high resolution SPECT system using four pinhole collimators for small animal studies.

1995 • 205 citations

Intracellular labeling of T‐cells with superparamagnetic contrast agents

1993 • 199 citations

Anisotropy in diffusion‐weighted MRI

1991 • 194 citations

Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse

1998 • 191 citations

Impaired Cardiac Energetics in Mice Lacking Muscle-Specific Isoenzymes of Creatine Kinase

1998 • 185 citations

Enhanced Optical Imaging of Human Gliomas and Tumor Margins

1996 • 183 citations

Measuring transferrin receptor gene expression by NMR imaging

1998 • 178 citations

Novel Features of Drosophila period Transcription Revealed by Real-Time Luciferase Reporting

1996 • 175 citations

In Vivo Dynamic MRI Tracking of Rat T‐Cells Labeled with Superparamagnetic Iron‐Oxide Particles

1995 • 172 citations

Magnetic Resonance Microscopy of Embryonic Cell Lineages and Movements

1994 • 171 citations

The design and physical characteristics of a small animal positron emission tomograph

1995 • 166 citations

Near-infrared spectroscopic localization of intracranial hematomas

1993 • 160 citations

Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour

1997 • 150 citations

NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels.

1990 • 141 citations

Alteration of Intracellular Metabolite Diffusion in Rat Brain In Vivo During Ischemia and Reperfusion

1995 • 137 citations

Restricted and anisotropic displacement of water in healthy cat brain and in stroke studied by NMR diffusion imaging

1991 • 132 citations

Pathfinding of Olfactory Neuron Axons to Stereotyped Glomerular Targets Revealed by Dynamic Imaging in Living Zebrafish Embryos

1998 • 130 citations

Bioenergetics: Dissecting the role of creatine kinase

1994 • 127 citations

Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography.

1998 • 123 citations

In vivo Measurement of Water Self Diffusion in the Human Brain by Magnetic Resonance Imaging

1987 • 121 citations

Cardiac MRI of the normal and hypertrophied mouse heart

1998 • 114 citations

Magnetic resonance imaging accurately estimates LV mass in a transgenic mouse model of cardiac hypertrophy

1998 • 111 citations

Is there a role for GPIs in yeast cell-wall assembly?

1994 • 105 citations

A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z.

1993 • 103 citations

PET instrumentation: What are the limits?

1998 • 100 citations

A positron tomograph with 600 BGO crystals and 2.6 mm resolution

1988 • 99 citations

Effect of L‐dopa and 6‐hydroxydopamine lesioning on [¹¹C]raclopride binding in rat striatum, quantified using PET

1995 • 96 citations

In vivo MRI and its histological correlates in acute adoptive transfer experimental allergic encephalomyelitis

1996 • 95 citations

Brain dopamine transporter in spontaneously hypertensive rats.

1997 • 94 citations

In vivo activation of human immunodeficiency virus type 1 long terminal repeat by UV type A (UV-A) light plus psoralen and UV-B light in the skin of transgenic mice

1991 • 94 citations

MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis

1998 • 89 citations

New Technology for High‐Speed and High‐Resolution Optical Coherence Tomography^a

1998 • 88 citations

Phosphocreatine protects transgenic mouse liver expressing creatine kinase from hypoxia and ischemia

1993 • 86 citations

Real-time analysis of the transcriptional regulation of hiv and hcmv promoters in single mammalian cells

1995 • 84 citations

Transgenic mice aberrantly expressing human ornithine decarboxylase gene.

1991 • 82 citations

Receptor-targeted co-transport of DNA and magnetic resonance contrast agents

1995 • 80 citations

Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain

1994 • 74 citations

A discrete scintillation camera module using silicon photodiode readout of CsI(TI) crystals for breast cancer imaging

1998 • 73 citations

GDNF protects against 6-OHDA nigrostriatal lesion

1995 • 71 citations

Small animal imaging with pinhole single-photon emission computed tomography

1994 • 70 citations

Elevated Seizure Threshold and Impaired Spatial Learning in Transgenic Mice with Putrescine Overproduction in the Brain

1993 • 66 citations

Gated magnetic resonance imaging of normal and hypertrophied murine hearts

1997 • 63 citations

CCD imaging of luciferase gene expression in single mammalian cells

1990 • 62 citations

Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri‐infarct zone during focal cerebral ischemia

1997 • 61 citations

Expression of functional mitochondrial creatine kinase in liver of transgenic mice

1997 • 61 citations

Initial results from a PET/planar small animal imaging system

1999 • 59 citations

In vivo evaluation of [11C]-and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography

1996 • 59 citations

Fourier spatial filter acts as a temporal gate for light propagating through a turbid medium

1995 • 58 citations

PET radiopharmaceuticals: state-of-the-art and future prospects

1998 • 56 citations

DNA Injection into Single Cells of Intact Mice

1999 • 52 citations

Phosphocreatine protects ATP from a fructose load in transgenic mouse liver expressing creatine kinase

1991 • 50 citations

Use of a YAP:Ce matrix coupled to a position-sensitive photomultiplier for high resolution positron emission tomography

1996 • 49 citations

Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner

1995 • 47 citations

Long-term expression of a fluorescent reporter gene via direct injection of plasmid vector into mouse skeletal muscle: Comparison of human creatine kinase and CMV promoter expression levels in vivo

1996 • 45 citations

Time‐Resolved and Nonlinear Optical Imaging for Medical Applications^a

1998 • 44 citations

Enhanced Optical Imaging of Rat Gliomas and Tumor Margins

1994 • 42 citations

Conceptual design of a high-sensitivity small animal PET camera with 4/spl pi/ coverage

1999 • 42 citations

Design features and performance of a CsI(Na) array based gamma camera for small animal gene research

1998 • 42 citations

Myocardial infarction in rats: high-resolution single-photon emission tomographic imaging with a pinhole collimator

1996 • 38 citations

Cerebral Energy Metabolism and Immediate Early Gene Induction Following Severe Incomplete Ischaemia in Transgenic Mice Overexpressing the Human Ornithine Decarboxylase Gene: Evidence that Putrescine is not Neurotoxic In Vivo

1995 • 37 citations

In vivo noninvasive determination of abnormal water diffusion in the rat brain studied in an animal model for multiple sclerosis by diffusion-weighted NMR imaging

1996 • 35 citations

Insights into cellular energy metabolism from transgenic mice

1995 • 34 citations

Photon counting imaging: applications in biomedical research.

1989 • 34 citations

Expression of truncated utrophin improves pH recovery in exercising muscles of dystrophic mdx mice: a 31P NMR study

1998 • 33 citations

High resolution high field rodent cardiac imaging with flow enhancement suppression

1994 • 33 citations

Spatial imaging of luciferase gene expression in transgenic fish

1990 • 30 citations

A small animal PET prototype based on LSO crystals read out by avalanche photodiodes

1997 • 29 citations

Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors

1996 • 29 citations

Distribution of cocaine recognition sites in rat brain: In vitro and ex vivo autoradiography with [125I]RTI-55

1994 • 27 citations

Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease.

1996 • 26 citations

Altered brain glucose metabolism in transgenic-PFKL mice with elevated l-phosphofructokinase: in vivo NMR studies

1998 • 25 citations

In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice

1998 • 23 citations

Nuclear Magnetic Resonance Spectroscopy Study on Energy Metabolism, Intracellular pH, and Free Mg2+Concentration in the Brain of Transgenic Mice Overexpressing Human Ornithine Decarboxylase Gene

1992 • 22 citations

High-resolution MR imaging in mice

1998 • 21 citations

NMR Imaging and Spectroscopy of the Mammalian Central Nervous System after Heavy Ion Radiation

1988 • 21 citations

Contractile and metabolic effects of increased creatine kinase activity in mouse skeletal muscle

1996 • 21 citations

Experimental allergic encephalomyelitis in non‐human primates: mri and mrs may predict the type of brain damage

1995 • 21 citations

Cardiac blood-pool scintigraphy in rats and hamsters: comparison of five radiopharmaceuticals and three pinhole collimator apertures.

1991 • 19 citations

Neuronal Synchronization and Ionic Mechanisms for Propagation of Excitation in the Functional Network of Immortalized GT1–7 Neurons: Optical Imaging with a Voltage‐Sensitive Dye

1997 • 19 citations

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1998 • 18 citations

Long-Term Expression of a Fluorescent Reporter Gene via Direct Injection of Plasmid Vector into Mouse Skeletal Muscle: Comparison of Human Creatine Kinase and Cmv Promoter Expression Levels in Vivo

1996 • 18 citations

Application of Localized In Vivo NMR to Whole Organ Physiology in the Animal

1992 • 18 citations

HIV-1 LTR ACTIVATION MODEL

1992 • 17 citations

Autoradiography and radioscintigraphy of technetium-99m-sestamibi in c-neu transgenic mice.

1995 • 14 citations

Gated blood-pool studies of cardiac function in the rat and marmoset.

1983 • 13 citations

Development of central 5-HT2A receptor radioligands for PET: Comparison of [3H]RP 62203 and [3H]SR 46349B kinetics in rat brain

1996 • 12 citations

Untitled

1997 • 9 citations

Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR

1997 • 9 citations

Tantalum-178-labeled agents for lung and liver imaging.

1979 • 8 citations

Nuclear Magnetic Resonance Detection of the Consequences of Transgene Expression

1994 • 8 citations

Early Clinical Results of Time-of-Flight Optical Tomography in a Neonatal Intensive Care Unit

1996 • 5 citations

Gamma‐detecting probe and autoradiographic studies of radiolabeled antibody B72.3 in CX‐1 colon xenografts

1990 • 4 citations