Pathogens target DC‐SIGN to influence their fate DC‐SIGN functions as a pathogen receptor with broad specificity

Dendritic cells and the control of immunity

1998 • 14,345 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.

1990 • 975 citations

Mechanisms That Regulate the Function of the Selectins and Their Ligands

1999 • 931 citations

C-type lectin receptors on dendritic cells and langerhans cells

2002 • 824 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction

2001 • 749 citations

Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR

2001 • 659 citations

C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans

2002 • 642 citations

Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 ⁺ T Cells

1992 • 624 citations

DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells

2002 • 620 citations

The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells

2002 • 613 citations

Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors.

1993 • 603 citations

Local control of the immune response in the liver

2000 • 593 citations

Diversity of receptors binding HIV on dendritic cell subsets

2002 • 515 citations

DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection

2002 • 513 citations

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1

1994 • 505 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 499 citations

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

2000 • 498 citations

A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR

2001 • 497 citations

Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro

2002 • 448 citations

Mannosylated Lipoarabinomannans Inhibit IL-12 Production by Human Dendritic Cells: Evidence for a Negative Signal Delivered Through the Mannose Receptor

2001 • 415 citations

Cells in the Marginal Zone of the Spleen

1992 • 411 citations

Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guérin: Involvement of Toll-Like Receptors

2000 • 405 citations

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

1992 • 381 citations

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

1994 • 358 citations

Human Cytomegalovirus Binding to DC-SIGN Is Required for Dendritic Cell Infection and Target Cell trans-Infection

2002 • 358 citations

A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

2001 • 351 citations

Mycobacterial lipoarabinomannan: An extraordinary lipoheteroglycan with profound physiological effects

1998 • 350 citations

Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages.

1994 • 347 citations

The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

1997 • 339 citations

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans

2001 • 322 citations

Hijacking and exploitation of IL-10 by intracellular pathogens

2001 • 314 citations

Immunopathology of tuberculosis: roles of macrophages and monocytes

1996 • 308 citations

Nef-Induced CD4 Degradation

1999 • 282 citations

Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

2001 • 261 citations

Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p13

2000 • 257 citations

Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques

2002 • 256 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

Dendritic Cells Are Host Cells for Mycobacteria In Vivo That Trigger Innate and Acquired Immunity

2002 • 217 citations

Targeting the Function of Mature Dendritic Cells by Human Cytomegalovirus

2001 • 216 citations

Induction of Th2 Responses and IgE Is Largely Due to Carbohydrates Functioning as Adjuvants onSchistosoma mansoniEgg Antigens

1999 • 213 citations

HIV-1 Nef-Induced Upregulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread

2002 • 189 citations

Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo

2002 • 188 citations

Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN

2001 • 185 citations

Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1

2002 • 184 citations

Macrophage Recognition of ICAM-3 on Apoptotic Leukocytes

1999 • 183 citations

cisExpression of DC-SIGN Allows for More Efficient Entry of Human and Simian Immunodeficiency Viruses via CD4 and a Coreceptor

2001 • 179 citations

Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

2002 • 171 citations

Dendritic Cell (DC)-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN, CD209), a C-type Surface Lectin in Human DCs, Is a Receptor for LeishmaniaAmastigotes

2002 • 162 citations

Expression of multilectin receptors and comparative FITC–dextran uptake by human dendritic cells

2000 • 158 citations

Subset of DC-SIGN+ dendritic cells in human blood transmits HIV-1 to T lymphocytes

2002 • 144 citations

Why Helicobacter pylori has Lewis antigens

2000 • 116 citations

Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis

2001 • 116 citations

Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?

1998 • 114 citations

The human blood fluke Schistosoma mansoni synthesizes glycoproteins containing the Lewis X antigen.

1992 • 114 citations

Interaction of dendritic cells with mycobacteria: Where the action starts

2000 • 112 citations

Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1.

1992 • 106 citations

Evaluation of lipoarabinomannan for the serological diagnosis of tuberculosis

1990 • 99 citations

Human Immunodeficiency Virus Envelope (gp120) Binding to DC-SIGN and Primary Dendritic Cells Is Carbohydrate Dependent but Does Not Involve 2G12 or Cyanovirin Binding Sites: Implications for Structural Analyses of gp120-DC-SIGN Binding

2002 • 88 citations

Increasing diversity of animal lectin structures

1995 • 86 citations

Intercellular adhesion molecule‐3 is the predominant co‐stimulatory ligand for leukocyte function antigen‐1 on human blood dendritic cells

1995 • 81 citations

DC-SIGN and LFA-1: a battle for ligand

2001 • 78 citations

Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN

2001 • 76 citations

DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable Functions

2001 • 71 citations

Nef Is Required for Efficient HIV-1 Replication in Cocultures of Dendritic Cells and Lymphocytes

2001 • 69 citations

Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA.

1992 • 59 citations

Characteristics of antigen‐independent and antigen‐dependent interaction of dendritic cells with CD4⁺ T cells

1995 • 57 citations

Characterization of murine intercellular adhesion molecule-2.

1996 • 54 citations

Synthetic mannosides act as acceptors for mycobacterial α1-6 mannosyltransferase

2001 • 50 citations

DC-SIGN, a Dentritic Cell-Specific HIV-1 Receptor Present in Placenta That Infects T Cells In Trans—A Review

2001 • 49 citations

Distribution and Immunophenotype of DC-SIGN-Expressing Cells in SIV-Infected and Uninfected Macaques

2002 • 46 citations

Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8α− splenic dendritic cells

2001 • 42 citations

Capture and Transfer of Simian Immunodeficiency Virus by Macaque Dendritic Cells Is Enhanced by DC-SIGN

2002 • 33 citations

Involvement of the CDw50 molecule in allorecognition

1990 • 30 citations

Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN

2001 • 30 citations

Structural study of N‐linked oligosaccharides of human intercellular adhesion molecule‐3 (CD50)

2001 • 23 citations