The Fas/APO-1 receptor and its deadly ligand

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

1994 • 238 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Thymic selection: a matter of life and death

1992 • 184 citations

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

1994 • 182 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

1990 • 146 citations

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

1990 • 133 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

1992 • 97 citations

Differential expression of APO‐1 on human thymocytes: Implications for negative selection?

1994 • 67 citations

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

1992 • 49 citations