Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Selective release of glutamate from cerebellar granule cells differentiating in culture

1982 • 501 citations

Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.

1989 • 484 citations

Neural apoptosis

1995 • 464 citations

N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture

1988 • 437 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1993 • 331 citations

Role of ornithine decarboxylase and the polyamines in nervous system development: A review

1986 • 242 citations

Polyamines Differentially Modulate the Transcription of Growth-associated Genes in Human Colon Carcinoma Cells

1989 • 211 citations

Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.

1996 • 199 citations

Brain-derived neurotrophic factor (bdnf) can prevent apoptosis of rat cerebellar granule neurons in culture

1995 • 184 citations

Spermine prevents endonuclease activation and apoptosis in thymocytes*1

1991 • 181 citations

The survival of developing neurons: A review of afferent control

1994 • 181 citations

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

1994 • 175 citations

The cellular neurobiology of neuronal development: The cerebellar granule cell

1988 • 174 citations

Polyamine Regulation of N-Methyl-D-Aspartate Receptor Channels

1995 • 162 citations

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

1992 • 157 citations

Modulation of channel function by polyamines

1996 • 156 citations

A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen.

1992 • 154 citations

Selective loss of Purkinje and granule cell responsiveness to in rat cerebellum during development

1987 • 139 citations

Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells

1996 • 138 citations

Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain

1991 • 122 citations

Activation of Metabotropic Glutamate Receptors Prevents Neuronal Apoptosis in Culture

1995 • 119 citations

Polyamines in neurotrauma

1992 • 111 citations

Numerical matching during cerebellar development: quantitative analysis of granule cell death in staggerer mouse chimeras

1987 • 107 citations

Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach

1991 • 89 citations

Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress

1991 • 85 citations

Regulation of the Expression of NMDA Receptor Subunits in Rat Cerebellar Granule Cells: Effect of Chronic K⁺‐Induced Depolarization and NMDA Exposure

1995 • 70 citations

Effects of α-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: Critical perinatal periods for regional selectivity

1986 • 64 citations

NEUROCHEMICAL ASPECTS OF NEURONAL ONTOGENESIS IN THE DEVELOPING RAT CEREBELLUM: CHANGES IN NEUROTRANSMITTER AND POLYAMINE SYNTHESIZING ENZYMES

1979 • 57 citations

Oxygen toxicity in a polyamine-depleted spe2 delta mutant of Saccharomyces cerevisiae.

1993 • 57 citations

Growth conditions differentially modulate the vulnerability of developing cerebellar granule cells to excitatory amino acids

1994 • 53 citations

Blockade of Ornithine Decarboxylase Enzyme Protects against Ischemic Brain Damage

1994 • 52 citations

Early polyamine treatment enhances survival of sympathetic neurons after postnatal axonal injury or immunosympathectomy

1988 • 46 citations

Polyamines influence transglutaminase activity and cell migration in two cell lines

1994 • 32 citations

Polyamine treatment in early development leads to increased numbers of rat sympathetic neurons

1985 • 29 citations

Allosteric Activation off Brain Mitochondrial Ca²⁺ Uptake by Spermine and by Ca²⁺: Developmental Changes

1989 • 25 citations

Polyamines affect growth of cultured rat cerebellar neurons in different sera

1986 • 25 citations

Differing effects of α-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia

1992 • 25 citations

Ornithine Decarboxylase Activity and Edema Formation in Cerebral Ischemia of Conscious Gerbils

1995 • 22 citations

Effect of polyamines on purified poly(ADP-ribose) synthetase from rat liver nuclei

1981 • 22 citations

Trophic control of the ornithine decarboxylase/polyamine system in neonatal rat brain regions: lesions caused by 6-hydroxydopamine produce effects selective for cerebellum

1990 • 12 citations

Ontogenetic changes in laminar distribution of ornithine decar☐ylase during development of cerebellar cortex: autoradiographic localization with [3h]α-difluoromethylornithine

1988 • 11 citations