Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles

1985 • 1,425 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer

1972 • 1,001 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer

1972 • 914 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer

1972 • 626 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF

1995 • 572 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation

1972 • 456 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1994 • 397 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1994 • 313 citations

Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons

1995 • 307 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins

1994 • 294 citations

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

1993 • 293 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Neurotrophic molecules

1989 • 270 citations

Widespread and Developmentally Regulated Expression of Neurotrophin‐4 mRNA in Rat Brain and Peripheral Tissues

1993 • 256 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Cell-cell interactions influence survival and differentiation of purified purkinje cells in vitro

1994 • 252 citations

Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.

1989 • 251 citations

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons

1992 • 240 citations

The effects of early hypo- and hyperthyroidism on the development of the rat cerebellar cortex. II. Synaptogenesis in the molecular layer

1972 • 220 citations

Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells

1995 • 216 citations

Nerve growth factor: a tale of two receptors.

1993 • 215 citations

Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

1994 • 212 citations

Postnatal maturation of cerebellar mossy and climbing fibers: transient expression of dual features on single axons

1984 • 210 citations

Synaptophysin expression during synaptogenesis in the rat cerebellar cortex

1989 • 204 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

Synaptogenesis in the Rat Cerebellum: Effects of Early Hypo- and Hyperthyroidism

1972 • 198 citations

Independent Expression of the α and β c-erbA Genes in Developing Rat Brain

1991 • 195 citations

Brain-derived neurotrophic factor (bdnf) can prevent apoptosis of rat cerebellar granule neurons in culture

1995 • 184 citations

Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation

1993 • 181 citations

trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.

1993 • 178 citations

Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and low-affinity nerve growth factor receptor during the postnatal development of the rat cerebellar system

1993 • 173 citations

Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation

1995 • 172 citations

Effects of Neonatal Hypothyroidism on Rat Brain Gene Expression

1991 • 144 citations

Postnatal development of the inferior olivary complex in the rat. II. Topographic organization of the immature olivocerebellar projection

1984 • 142 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Evidence for large-scale astrocyte death in the developing cerebellum

1995 • 130 citations

Effect of thyroid deficiency on cell acquisition in the postnatal rat brain: A quantitative histological study

1976 • 112 citations

Localization of trkB mRNA in postnatal brain development

1993 • 104 citations

Immunofluorescence localization of thyroid hormone receptor protein beta 1 and variant alpha 2 in selected tissues: cerebellar Purkinje cells as a model for beta 1 receptor-mediated developmental effects of thyroid hormone in brain.

1991 • 98 citations

Morphogenetic actions of thyroid hormones

1979 • 96 citations

Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells

1994 • 90 citations

Spatiotemporal selective effects on brain-derived neurotrophic factor andtrkB messenger RNA in rat hippocampus by electroconvulsive shock

1995 • 86 citations

Excitatory and inhibitory processes acting upon cerebellar Purkinje cells during maturation in the rat; Influence of hypothyroidism

1974 • 77 citations

Gene expression in the developing cerebellum during perinatal hypo- and hyperthyroidism

1993 • 74 citations

Isoforms of the avian TrkC receptor: A novel kinase insertion dissociates transformation and process outgrowth from survival

1994 • 72 citations

Biochemical, Immunocytochemical and Morphological Evidence for an Interaction between Thyroid Hormone and Nerve Growth Factor in the Developing Cerebellum of Normal and Hypothyroid Rats

1991 • 41 citations

Tri-iodothyronine regulates survival and differentiation of rat cerebellar granule neurons

1992 • 37 citations

Neurotrophin-3 selectively increases cultured Purkinje cell survival

1994 • 35 citations

[Analysis of the morphogenetic action of thyroid hormones on the cerebellum of young rats].

1967 • 33 citations

Thyroid Hormone Promotes Transient Nerve Growth Factor Synthesis in Rat Cerebellar Neuroblasts

1992 • 25 citations

Nerve growth factor enhances DNA synthesis in cultured cerebellar neuroblasts

1991 • 17 citations

R�percussions de l'hypothyro�die sur la synaptogen�se dans le cortex c�r�belleux du rat

1976 • 16 citations

Thyroid state and cholecalcin (calcium-binding protein) in cerebellum of the developing rat

1986 • 12 citations