Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

2003 • 8,039 citations

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Neurobiology of Depression

2002 • 3,057 citations

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

2001 • 2,667 citations

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

1999 • 2,365 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

STRESS AND HIPPOCAMPAL PLASTICITY

1999 • 2,023 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

2000 • 1,927 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

2002 • 1,627 citations

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

2002 • 1,579 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

1995 • 1,429 citations

Control of Synapse Number by Glia

2001 • 1,327 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

Adult brain neurogenesis and psychiatry: a novel theory of depression

2000 • 936 citations

Reducing Suicide--A National Imperative

2002 • 909 citations

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

2002 • 901 citations

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

2003 • 831 citations

Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)

1997 • 829 citations

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

2000 • 810 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement

2000 • 747 citations

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion

1996 • 737 citations

Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide

2003 • 730 citations

Restoring production of hippocampal neurons in old age

1999 • 717 citations

Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression

1998 • 694 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

Pet imaging of serotonin 1A receptor binding in depression

1999 • 665 citations

Neural plasticity to stress and antidepressant treatment

1999 • 638 citations

Enhancement of Hippocampal Neurogenesis by Lithium

2000 • 613 citations

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 • 604 citations

Neuronal Cell Death

1998 • 593 citations

Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration

2001 • 587 citations

Fluvoxamine for the Treatment of Anxiety Disorders in Children and Adolescents

2001 • 585 citations

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

2002 • 570 citations

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone

2000 • 559 citations

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

2002 • 513 citations

Gender Differences in the Rates of Exposure to Stressful Life Events and Sensitivity to Their Depressogenic Effects

2001 • 509 citations

cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment

2000 • 503 citations

Antidepressants and neuroplasticity

2002 • 498 citations

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

2003 • 494 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease

1999 • 450 citations

Bcl-2 promotes regeneration of severed axons in mammalian CNS

1997 • 449 citations

Neuroplasticity Failure in Alzheimer's Disease

1999 • 442 citations

Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

1997 • 424 citations

Distribution of Corticosteroid Receptors in the Rhesus Brain: Relative Absence of Glucocorticoid Receptors in the Hippocampal Formation

2000 • 422 citations

Relapse of depression after rapid depletion of tryptophan

1997 • 421 citations

Regulation of hippocampal neurogenesis in adulthood

2000 • 402 citations

Stressful life events and genetic liability to major depression: genetic control of exposure to the environment?

1997 • 335 citations

A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression

2002 • 329 citations

Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics.

2001 • 328 citations

Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect

2001 • 312 citations

Mice Lacking the Serotonin Transporter Exhibit 5-HT1A Receptor-Mediated Abnormalities in Tests for Anxiety-like Behavior

2003 • 310 citations

Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness

2000 • 291 citations

Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons

2000 • 283 citations

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

1999 • 271 citations

Chapter 35 Serotonin brain circuits involved in major depression and suicide

2002 • 256 citations

Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain

2000 • 245 citations

Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress

2001 • 239 citations

Repeated stress increases catalytic TrkB mRNA in rat hippocampus

1999 • 237 citations

Regulation of adult hippocampal neurogenesis – implications for novel theories of major depression¹

2002 • 233 citations

The American Psychiatric Publishing textbook of psychopharmacology

2010 • 229 citations

Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

2003 • 222 citations

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

2001 • 221 citations

The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.

2001 • 218 citations

Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I

2002 • 206 citations

Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.

1990 • 203 citations

Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone

2001 • 203 citations

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells

2002 • 198 citations

Update on the therapeutic potential of PDE4 inhibitors

2002 • 194 citations

The α_2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

2001 • 187 citations

Abnormal Expression and Functional Characteristics of Cyclic Adenosine Monophosphate Response Element Binding Protein in Postmortem Brain of Suicide Subjects

2003 • 178 citations

Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders

2003 • 167 citations

Chronic social stress: effects on limbic brain structures

2003 • 166 citations

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropinreleasing hormone

2000 • 160 citations

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

2002 • 157 citations

Dynamics of central nervous 5-HT1A-receptors under psychosocial stress

1995 • 157 citations

Future therapeutic targets in mood disorders: the glucocorticoid receptor

2000 • 156 citations

Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice

2000 • 150 citations

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

2001 • 145 citations

Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression

1999 • 133 citations

Current perspectives on the development of non-biogenic amine-based antidepressants

2001 • 133 citations

Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression

2003 • 132 citations

Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes

2001 • 131 citations

Recognition Sites for Norepinephrine Uptake: Regulation by Neurotransmitter

1983 • 129 citations

Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

1999 • 123 citations

The next generation of PDE4 inhibitors

2001 • 122 citations

Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder

2003 • 120 citations

Transient Depressive Relapse Induced by Catecholamine Depletion

1999 • 119 citations

Selective chronic stress‐induced in vivo ERK1/2 hyperphosphorylation in medial prefrontocortical dendrites: implications for stress‐related cortical pathology?

2002 • 119 citations

Mind Glue

2000 • 117 citations

Serum cortisol response to transsphenoidal surgery for Cushing disease

2001 • 111 citations

Administration of a cAMP Phosphodiesterase 4 Inhibitor Enhances Antidepressant-Induction of BDNF mRNA in Rat Hippocampus

2000 • 109 citations

Sequence variations in CREB1 cosegregate with depressive disorders in women

2003 • 90 citations

Increased neurogenesis and brain‐derived neurotrophic factor in neurokinin‐1 receptor gene knockout mice

2003 • 84 citations

Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion

2002 • 81 citations

Survival Signaling and Selective Neuroprotection Through Glutamatergic Transmission

2002 • 71 citations

Differential In Vivo Regulation of mRNA Encoding the Norepinephrine Transporter and Tyrosine Hydroxylase in Rat Adrenal Medulla and Locus Ceruleus

1995 • 65 citations

Signal Transduction and Genes-to-Behaviors Pathways in Psychiatric Diseases

2003 • 64 citations

Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2/N Neurons

2003 • 61 citations

Elucidating the antidepressant actions of substance P (NK1 receptor) antagonists.

2002 • 54 citations

Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum

2001 • 39 citations

Why do mature CNS neurons of mammals fail to re-establish connections following injury–functions of Bcl-2

1998 • 37 citations

Effect of Chronic Administration of Antidepressants on α2-Adrenoceptors in the Locus Coeruleus and Its Projection Fields in Rat Brain Determined by Quantitative Autoradiography

1993 • 35 citations

Mood Disorders in Neurodegenerative Diseases.

1996 • 12 citations