Macrophages from Inflamed but Not Normal Glomeruli Are Unresponsive to Anti-Inflammatory Cytokines

Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

1966 • 4,504 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

1998 • 954 citations

THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO

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Activated macrophages induce vascular proliferation

1977 • 818 citations

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

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Cytokines in context.

1991 • 808 citations

RECEPTORS FOR COMPLEMENT ON LEUKOCYTES

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Structure and Function of Human and Murine Receptors for IgG

1988 • 468 citations

Secretion of a specific collagenase by stimulated macrophages.

1975 • 432 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes.

1988 • 411 citations

Modulation of Macrophage Function by Transforming Growth Factor ?, Interleukin-4, and Interleukin-10

1993 • 393 citations

The concept of the activated macrophage.

1978 • 383 citations

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.

1996 • 381 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

MIP-1alpha as a critical macrophage chemoattractant in murine wound repair.

1998 • 275 citations

Abrogation of Macrophage-dependent Injury in Experimental Glomerulonephritis in the Rabbit

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1978 • 203 citations

Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines

1998 • 178 citations

Evidence for a pathogenic role of a cell-mediated immune mechanism in experimental glomerulonephritis.

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Glomeruli synthesize nitrite in experimental nephrotoxic nephritis

1990 • 137 citations

Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4⁺ T cells in vitro

1997 • 123 citations

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

1991 • 123 citations

Immune modulation with interleukin‐4 and interleukin‐10 prevents crescent formation and glomerular injury in experimental glomerulonephritis

1997 • 122 citations

Macrophages in acute glomerular inflammation

1994 • 114 citations

Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha.

1994 • 99 citations

Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice

1997 • 97 citations

The role of polymorphonuclear leucocytes in the autologous phase of nephrotoxic nephritis.

1975 • 74 citations

Previous Uptake of Apoptotic Neutrophils or Ligation of Integrin Receptors Downmodulates the Ability of Macrophages to Ingest Apoptotic Neutrophils

1999 • 72 citations

Monocytes cultured in cytokine-defined environments differ from freshly isolated monocytes in their responses to IL-4 and IL-10

1995 • 65 citations

Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2.

1995 • 62 citations

Transforming growth factor-beta primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism.

1993 • 60 citations

Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines

1995 • 56 citations

Differential expression of macrophage inflammatory protein-2 and monocyte chemoattractant protein-1 in experimental glomerulonephritis

1996 • 49 citations

Isolation and characterization of inflammatory leukocytes from glomeruli in an in situ model of glomerulonephritis in the rat.

1987 • 46 citations

Interleukin-4 ameliorates experimental glomerulonephritis and up-regulates glomerular gene expression of IL-1 decoy receptor

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Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells

1998 • 41 citations

Development of functional diversity in mouse macrophages. Mutual exclusion of two phenotypic states.

1993 • 40 citations

Involvement of the IL-2 receptor gamma-chain (gammac) in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production.

1998 • 39 citations

Modulation of Macrophage Maturation by Cytokines and Lipid Mediators: A Potential Role in Resolution of Pulmonary Inflammationa

1994 • 39 citations

Glomerular expression of interleukin-1 receptor antagonist and interleukin-1 beta genes in antibody-mediated glomerulonephritis.

1994 • 36 citations

Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus

2000 • 34 citations

Cytochemically demonstrable B-glucuronidase activity in normal and neoplastic human lymphoid cells.

1980 • 34 citations

Modulation of antibody-mediated glomerular injury in vivo by interleukin-6

1993 • 34 citations

Two distinct pathways of human macrophage differentiation are mediated by interferon‐γ and interleukin‐10

1997 • 33 citations

Signalling heterogeneity as a contributing factor in macrophage functional diversity

1995 • 32 citations

Involvement of the IL-2 Receptor γ-Chain (γc) in the Control by IL-4 of Human Monocyte and Macrophage Proinflammatory Mediator Production

1998 • 30 citations

Isolation and characterization of a senescent cell antigen [letter]

1982 • 13 citations

Initial cytokine exposure determines macrophages’ function and renders them unresponsive to other cytokines

1998 • 10 citations