Signalling heterogeneity as a contributing factor in macrophage functional diversity

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Macrophage Tumor Killing: Influence of the Local Environment

1977 • 341 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

Macrophage Activation for Tumor Cytotoxicity: Development of Macrophage Cytotoxic Activity Requires Completion of A Sequence of Short-Lived Intermediary Reactions

1978 • 252 citations

Identification and characterization of the monoblast in mononuclear phagocyte colonies grown in vitro.

1975 • 213 citations

Functional characterization of a stable, noncytolytic stage of macrophage activation in tumors.

1977 • 187 citations

Resident macrophage proliferation in mice depleted of blood monocytes by strontium-89.

1982 • 166 citations

Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing.

1985 • 151 citations

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

1993 • 146 citations

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

1995 • 144 citations

Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide.

1987 • 140 citations

Selective diminution of the binding of mannose by murine macrophages in the late stages of activation.

1982 • 130 citations

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity

1991 • 108 citations

Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha.

1994 • 99 citations

Endotoxin suppresses expression of apoprotein E by mouse macrophages in vivo and in culture. A biochemical and genetic study.

1983 • 86 citations

Tumor Necrosis Factor-Alpha: Central Regulatory Cytokine in the Induction of Macrophage Antimicrobial Activities

1991 • 81 citations

On the origin of macrophage heterogeneity: a hypothesis.

1983 • 68 citations

Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state.

1991 • 67 citations

Macrophage heterogeneity occurs through a developmental mechanism.

1991 • 66 citations

Transforming growth factor-beta primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism.

1993 • 60 citations

Differential immunocompetence of macrophages derived using macrophage or granulocyte-macrophage colony-stimulating factor

1992 • 51 citations

Activation of p42mapk/erk2 following engagement of tumor necrosis factor receptor CD120a (p55) in mouse macrophages.

1995 • 46 citations

Development of functional diversity in mouse macrophages. Mutual exclusion of two phenotypic states.

1993 • 40 citations

Differential regulation of gene expression during macrophage activation with a polyribonucleotide. The role of endogenously derived IFN.

1988 • 39 citations

Modulation of Macrophage Maturation by Cytokines and Lipid Mediators: A Potential Role in Resolution of Pulmonary Inflammationa

1994 • 39 citations

Evidence for the pulmonary origin of alveolar macrophages

1982 • 38 citations

Bacterial lipopolysaccharide suppresses the production of catalytically active lysosomal acid hydrolases in human macrophages.

1986 • 23 citations

A PRELIMINARY STUDY ON THE EFFECT OF ALPHA-INTERFERON TREATMENT ON THE JOINT INFLAMMATION AND SERUM CALCIUM IN RHEUMATOID ARTHRITIS

1992 • 17 citations

Influence of the cytocidal macrophage phenotype on the degradation of acetylated low density lipoproteins: Dual regulation of scavenger receptor activity and of intracellular degradation of endocytosed ligand

1991 • 15 citations

Differences in antibody-dependent cellular cytotoxicity against tumor cells in in vitro differentiating mononuclear phagocytes from bone marrows of normal and inflamed mice

1982 • 8 citations