gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.

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1982 • 53,055 citations

Maps and guide to microdissection of the rat brain

1988 • 555 citations

THE γ-HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS

1997 • 453 citations

Brain microdialysis of GABA and glutamate: What does it signify?

1997 • 393 citations

Modulation of In Vivo Striatal Transmitter Release by Nitric Oxide and Cyclic GMP

1994 • 367 citations

The o-phthalaldehyde derivatives of amines for high-speed liquid chromatography/electrochemistry

1984 • 243 citations

Treatment of Narcolepsy with γ-Hydroxybutyrate. A Review of Clinical and Sleep Laboratory Findings

1986 • 227 citations

Evidence for GABAB-mediated mechanisms in experimental generalized absence seizures

1992 • 168 citations

A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.

1990 • 146 citations

Gamma-Hydroxybutyric Acid for Treatment of Opiate Withdrawal Syndrome

1993 • 115 citations

Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB.

1995 • 103 citations

Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat.

1979 • 99 citations

γ-Hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors

1992 • 98 citations

Selective distribution pattern of γ-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography

1992 • 95 citations

KINETICS OF IN VIVO CONVERSION OF γ‐[³H]AMINOBUTYRIC ACID TO γ‐[³H]HYDROXYBUTYRIC ACID BY RAT BRAIN^1,2

1977 • 91 citations

Gamma-hydroxybutyrate: a role in the regulation of central dopaminergic neurons?

1980 • 87 citations

gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.

1997 • 86 citations

Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB receptor-mediated hyperpolarization

1995 • 85 citations

The ontogeny of [ 3 H]γ-hydroxybutyrate and [ 3 H]GABA B binding sites: relation to the development of experimental absence seizures

1994 • 84 citations

Experimental absence seizures: potential role of γ-hydroxybutyric acid and GABAB receptors

1992 • 82 citations

Conversion of γ‐Hydroxybutyrate to γ‐Aminobutyrate In Vitro

1985 • 70 citations

Low doses of γ-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unanesthetized rats

1991 • 67 citations

Gamma hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat

1988 • 66 citations

METABOLISM OF γ‐HYDROXY‐[1‐¹⁴C] BUTYRATE BY RAT BRAIN: RELATIONSHIP TO THE KREBS CYCLE AND METABOLIC COMPARTMENTATION OF AMINO ACIDS

1978 • 59 citations

The anxiolytic effect of γ-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil

1998 • 58 citations

?-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors

1993 • 56 citations

Depolarization‐Evoked Release of γ‐Hydroxybutyrate from Rat Brain Slices

1983 • 55 citations

gamma-Hydroxybutyrate ligands possess antidopaminergic and neuroleptic-like activities.

1993 • 54 citations

GAMMA‐HYDROXYBUTYRATE DEGRADATION IN THE BRAIN IN VIVO: NEGLIGIBLE DIRECT CONVERSION TO GABA

1976 • 51 citations

Gamma-hydroxybutyrate, succinic semialdehyde and sleep

1973 • 50 citations

γ‐Hydroxybutyric Acid Increases Intracellular Ca²⁺ Concentration and Nuclear Cyclic AMP‐Responsive Element‐and Activator Protein 1 DNA‐Binding Activities Through GABA_B Receptor in Cultured Cerebellar Granule Cells

1995 • 47 citations

Plasma and central nervous system kinetics of gamma-hydroxybutyrate.

1979 • 46 citations

γ‐Hydroxybutyrate Stimulation of the Formation of Cyclic GMP and Inositol Phosphates in Rat Hippocampal Slices

1989 • 45 citations

γ-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin

1995 • 42 citations

γ-Butyrolactone-induced absence-like seizures increase nuclear CRE- and AP-1 DNA-binding activities in mouse brain

1996 • 38 citations

γ‐Hydroxybutyric Acid in Subcellular Fractions of Rat Brain

1987 • 34 citations

The effects of gamma-hydroxybutyrate on the membrane properties of guinea-pig pars compacta neurons in the substantia nigra in vitro

1989 • 33 citations

Regional differences in depolarization-induced release of γ-hydroxybutyrate from rat brain slices

1988 • 28 citations

In vivo Conversion of γ-Hydroxybutyrate into γ-Aminobutyrate

1966 • 27 citations

Immunocytochemical localization in rat brain of the enzyme that synthesizes γ-hydroxybutyric acid

1982 • 23 citations

Involvement of excitatory amino acid mechanisms in γ-hydroxybutyrate model of generalized absence seizures in rats

1992 • 19 citations

Conversion of γ-hydroxybutyrate to γ-aminobutyrate by mouse brain in vivo

1970 • 17 citations