In vivo conversion of γ-aminobutyric acid and 1,4-butanediol to γ-hydroxybutyric acid in rat brain

Identification of endogenous gamma-hydroxybutyrate in human and bovine brain and its regional distribution in human, guinea pig and rhesus monkey brain.

1978 • 144 citations

Conversion in vivo of γ-aminobutyric to γ-hydroxybutyric acid in the rat

1969 • 130 citations

Gamma-hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes

1984 • 129 citations

3-Mercaptopropionic acid: Convulsant properties, effects on enzymes of the γ-aminobutyrate system in mouse brain and antagonism by certain anticonvulsant drugs, aminooxyacetic acid and gabaculine

1979 • 108 citations

γ-butyrolactone and γ-hydroxybutyric acid—II. The pharmacologically active form

1966 • 92 citations

KINETICS OF IN VIVO CONVERSION OF γ‐[³H]AMINOBUTYRIC ACID TO γ‐[³H]HYDROXYBUTYRIC ACID BY RAT BRAIN^1,²

1977 • 91 citations

Formation and regional distribution of γ-hydroxybutyric acid in mammalian brain

1970 • 88 citations

PURIFICATION FROM HUMAN BRAIN AND SOME PROPERTIES OF TWO NADPH‐LINKED ALDEHYDE REDUCTASES WHICH REDUCE SUCCINIC SEMIALDEHYDE TO 4‐HYDROXYBUTYRATE

1979 • 88 citations

Evidence that central nervous system depression by 1,4-butanediol is mediated through a metabolite, gamma-hydroxybutyrate

1968 • 82 citations

Ontogeny of γ-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brain

1981 • 77 citations

Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain.

1977 • 73 citations

Conversion of γ‐Hydroxybutyrate to γ‐Aminobutyrate In Vitro

1985 • 70 citations

1,4 Butanediol, γ-hydroxybutyric acid and ethanol: Relationships and interactions

1984 • 68 citations

Gamma hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat

1988 • 66 citations

Metabolism of [1-14C]γ-hydroxybutyric acid by rat brain after intraventricular injection

1975 • 62 citations

Regional and Subcellular Localization in Rat Brain of the Enzymes That Can Synthesize γ‐Hydroxybutyric Acid

1981 • 59 citations

METABOLISM OF γ‐HYDROXY‐[1‐¹⁴C] BUTYRATE BY RAT BRAIN: RELATIONSHIP TO THE KREBS CYCLE AND METABOLIC COMPARTMENTATION OF AMINO ACIDS

1978 • 59 citations

Specific and non‐specific succinic semialdehyde reductases from rat brain: Isolation and properties

1980 • 57 citations

GAMMA‐HYDROXYBUTYRATE DEGRADATION IN THE BRAIN IN VIVO: NEGLIGIBLE DIRECT CONVERSION TO GABA

1976 • 51 citations

FORMATION OF GAMMA‐HYDROXYBUTYRATE IN BRAIN¹

1977 • 51 citations

Evaluation and development of gas chromatographic procedures for the determination of γ-hydroxybutyric acid and γ-butyrolactone in plasma

1978 • 49 citations

Plasma and central nervous system kinetics of gamma-hydroxybutyrate.

1979 • 46 citations

1,4 Butanediol and ethanol compete for degradation in rat brain and liver in vitro

1986 • 41 citations

Identification and quantitation of 1,4-butanediol in mammalian tissues: an alternative biosynthetic pathway for gamma-hydroxybutyric acid

1985 • 41 citations

1,4-butanediol—A substrate for rat liver and horse liver alcohol dehydrogenases

1972 • 40 citations

Conversion of 1,4-butanediol to γ-hydroxybutyric acid in rat brain and in peripheral tissue

1972 • 39 citations

Evidence for the Participation of a Cytosolic NADP⁺‐Dependent Oxidoreductase in the Catabolism of γ‐Hydroxybutyrate In Vivo

1987 • 33 citations

Endogenous γ‐Hydroxybutyrate in Rat Brain Areas: Postmortem Changes and Effects of Drugs Interfering with γ‐Aminobutyric Acid Metabolism

1983 • 33 citations

Studies on the relation of γ-hydroxybutyric acid (GHB) to γ-aminobutyric acid (GABA)

1982 • 32 citations

Regulation and Properties of an NADP⁺ Oxidoreductase Which Functions as a γ‐Hydroxybutyrate Dehydrogenase

1983 • 29 citations

Kinetics of coupled gamma-hydroxybutyrate oxidation and D-glucuronate reduction by an NADP+-dependent oxidoreductase.

1981 • 28 citations

Evidence for a role of high K_m aldehyde reductase in the degradation of endogenous γ‐hydroxybutyrate from rat brain

1985 • 26 citations

Metabolic factors involved in the interaction between pyrazole and butane-1, 4-diol and 4-hydroxybutyric acid

1972 • 24 citations

A rapid and sensitive method for the determination of γ-hydroxybutyric acid andtrans-γ-hydroxycrotonic acid in rat brain tissue by gas chromatography/mass spectrometry with negative ion detection

1988 • 18 citations

Evaluation of gamma‐hydroxybutyrate formed from L‐glutamate by mouse brain homogenate

1978 • 13 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...