Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

1995 • 922 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

1991 • 519 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

1993 • 372 citations

Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos

1992 • 348 citations

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

1994 • 337 citations

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

1993 • 313 citations

Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

1992 • 313 citations

DNA Binding Specificity of the CCAAT/Enhancer-binding Protein Transcription Factor Family

1996 • 300 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Aspirin use, cancer, and polyps of the large bowel

1993 • 285 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.

1994 • 243 citations

Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element.

1993 • 234 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Immunochemical Characterization and Transacting Properties of Upstream Stimulatory Factor Isoforms

1996 • 202 citations

The cyclic AMP response element plays an essential role in the expression of the human prostaglandin‐endoperoxide synthase 2 gene in differentiated U937 monocytic cells

1994 • 185 citations

Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions

1993 • 177 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

Autoregulation of the Human C/EBPα Gene by Stimulation of Upstream Stimulatory Factor Binding

1995 • 156 citations

Evidence for Posttranscriptional Regulation of C/EBPα and C/EBPβ Isoform Expression during the Lipopolysaccharide-Mediated Acute-Phase Response†

1996 • 155 citations

Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene.

1994 • 152 citations

Basal expression of cyclooxygenase-2 and nuclear factor–interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet

1998 • 141 citations

Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.

1993 • 136 citations

Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression

1995 • 134 citations

Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

1995 • 133 citations

Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl₂on specificity and comparison with binding of Myc family members

1994 • 126 citations

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding.

1992 • 124 citations

Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation.

1994 • 118 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β Type II Receptor Gene

1995 • 116 citations

An E-box Region within the Prostaglandin Endoperoxide Synthase-2 (PGS-2) Promoter Is Required for Transcription in Rat Ovarian Granulosa Cells

1996 • 110 citations

Tumor Necrosis Factor α Promotes Nuclear Localization of Cytokine-inducible CCAAT/Enhancer Binding Protein Isoforms in Hepatocytes

1996 • 104 citations

Assembly of a bZIP-bHLH transcription activation complex: formation of the yeast Cbf1-Met4-Met28 complex is regulated through Met28 stimulation of Cbf1 DNA binding

1997 • 90 citations

Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.

1994 • 89 citations

CCAAT/Enhancer-binding Protein-δ (C/EBP-δ) Is Induced in Growth-arrested Mouse Mammary Epithelial Cells

1997 • 80 citations

Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor.

1994 • 78 citations

CCAAT/Enhancer-binding Protein δ Activates Insulin-like Growth Factor-I Gene Transcription in Osteoblasts

1997 • 75 citations

Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice.

1993 • 73 citations

Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein.

1996 • 65 citations

DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter

1995 • 60 citations

Binding of Upstream Stimulatory Factor and a Cell-specific Activator to the Calcitonin/Calcitonin Gene-related Peptide Enhancer

1997 • 55 citations

Expression of the liver‐enriched transcription factors C/EBPα, C/EBPβ, HNF‐1, and HNF‐4 in preneoplastic nodules and hepatocellular carcinoma in rat liver

1995 • 51 citations

In vivo behavior of murine epidermal cell lines derived from initiated and noninitiated skin.

1988 • 37 citations

Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin

1996 • 27 citations

Changes in protein expression during multistage mouse skin carcinogenesis.

1997 • 26 citations

Changes in protein expression during multistage mouse skin carcinogenesis

1997 • 20 citations

Modulation of Prostaglandin G/H Synthase Expression in Mesangial Cells Transfected by pp60c-srcProto-oncogene

1996 • 12 citations