The dominant negative effect of thyroid hormone receptor splicing variant alpha 2 does not require binding to a thyroid response element.

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.

1988 • 300 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.

1991 • 163 citations

Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.

1992 • 137 citations

Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.

1988 • 132 citations

Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.

1989 • 129 citations

Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform.

1992 • 101 citations

High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand-dependent dissociation.

1993 • 71 citations

Distinct dimerization domains provide antagonist pathways for thyroid hormone receptor action.

1993 • 52 citations

The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.

1993 • 46 citations

The roles of three forms of human thyroid hormone receptor in gene regulation

1990 • 23 citations