Action Mechanism of Retinoid-Synergistic Dibenzodiazepines

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

1994 • 367 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Transcription factors 3: nuclear receptors.

1995 • 327 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.

1995 • 257 citations

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

1992 • 256 citations

Retinoids in cancer prevention and therapy

1992 • 221 citations

Induction of differentiation of the human histiocytic lymphoma cell line U-937 by retinoic acid and cyclic adenosine 3':5'-monophosphate-inducing agents.

1982 • 219 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor α (RARα)-, RARβ-, or RARγ-Selective Ligand in Combination with a Retinoid X Receptor-Specific Ligand

1995 • 180 citations

Separation of Transactivation and AP1 Antagonism Functions of Retinoic Acid Receptor α

1995 • 168 citations

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

1996 • 164 citations

Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.

1996 • 113 citations

Identification of retinoids with nuclear receptor subtype-selective activities.

1991 • 105 citations

Selective Synthetic Ligands for Human Nuclear Retinoic Acid Receptors

1992 • 84 citations

Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor

1995 • 83 citations

Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.

1995 • 81 citations

Retinoids and Cancer Prevention

1992 • 74 citations

Potentiation of retinoid-induced differentiation of HL-60 and U937 cell lines by cytokines

1991 • 65 citations

Retinobenzoic Acids. 6. Retinoid Antagonists with a Heterocyclic Ring

1994 • 59 citations

Retinoids and interferon: a new promising combination?

1991 • 55 citations

Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells

1995 • 42 citations

Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor.

1996 • 30 citations

Expression of the Ligand-Binding Domain-Containing Region of Retinoic Acid Receptors .ALPHA., .BETA. and .GAMMA. in Escherichia coli and Evaluation of Ligand-Binding Selectivity.

1993 • 26 citations

A Novel Class of Retinoid Antagonists and Their Mechanism of Action

1996 • 25 citations

Fatty Acids and Retinoids Act Synergistically on Adipose Cell Differentiation

1994 • 21 citations

Enhancement by retinoid of hemin‐induced differentiation of human leukemia K562 cell line

1993 • 11 citations

Synergists for Retinoid in Cellular Differentiation of Human Promyelocytic Leukemia Cells HL-60.

1995 • 9 citations

Barbiturates enhance retinoic acid or 1,25-dihydroxyvitamin D3-induced differentiation of leukemia HL-60 cells

1991 • 6 citations

DESIGN OF NOVEL RXR SELECTIVE RETINOIDS

1995 • 5 citations