The Expression of Bcl-x Is Downregulated During Differentiation of Human Hematopoietic Progenitor Cells Along the Granulocyte But Not the Monocyte/Macrophage Lineage

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells

1984 • 420 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2

1996 • 348 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells

1992 • 276 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells

1991 • 178 citations

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells.

1990 • 149 citations

Clonal analysis of progenitor cell commitment to granulocyte or macrophage production

1982 • 145 citations

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): Receptor biology, signal transduction, and neutrophil activation

1992 • 138 citations

Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

1996 • 138 citations

Primitive human hematopoietic precursors express Bcl-x but not Bcl-2

1995 • 104 citations

Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

1995 • 99 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 96 citations

Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells

1993 • 92 citations

Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression

1995 • 82 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 75 citations

Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells

1993 • 68 citations

Myeloid differentiation of purified CD34+ cells after stimulation with recombinant human granulocyte-monocyte colony-stimulating factor (CSF), granulocyte-CSF, monocyte-CSF, and interleukin-3

1991 • 58 citations

Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells.

1992 • 44 citations

Granulomonocyte-associated lysosomal protein expression during in vitro expansion and differentiation of CD34+ hematopoietic progenitor cells

1995 • 40 citations

Developmental regulation of myeloid gene expression and demethylation during ex vivo culture of peripheral blood progenitor cells

1996 • 30 citations

Genetic programs of myeloid cell differentiation.

1994 • 20 citations