Inositol monophosphatase, the putative therapeutic target for lithium

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

INOSITOL PHOSPHATE BIOCHEMISTRY

1992 • 402 citations

Reduced Brain Inositol in Lithium-treated Rats

1971 • 309 citations

Inositol Lipids and Signal Transduction in the Nervous System: An Update

1992 • 260 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

d-Myoinositol 1-Phosphate as Product of Cyclization of Glucose 6-Phosphate and Substrate for a Specific Phosphatase in Rat Testis

1967 • 252 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Inositol lipids in cell signalling.

1989 • 212 citations

Lithium and brain signal transduction systems

1994 • 200 citations

The purification and properties of myo-inositol monophosphatase from bovine brain

1988 • 174 citations

A review of the biochemical and neuropharmacological actions of lithium

1987 • 171 citations

Inositol lipids in cell signalling

1992 • 127 citations

Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain

1989 • 125 citations

Long‐term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C

1994 • 122 citations

Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes

1974 • 115 citations

Effects of lithium on phosphoinositide metabolism in vivo.

1986 • 109 citations

Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.

1978 • 108 citations

Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression

1993 • 105 citations

Inositol monophosphatase — a putative target for Li+ in the treatment of bipolar disorder

1995 • 105 citations

Identification of scyllo‐inositol in proton NMR spectra of human brain in vivo

1993 • 95 citations

Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS

1991 • 95 citations

Purification and Properties of myo-Inositol-1-Phosphatase from Rat Brain

1985 • 86 citations

Changes in excitatory amino acid modulation of phosphoinositide metabolism during development

1990 • 81 citations

Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness

1994 • 80 citations

Enhanced Coupling of Neonatal Muscarinic Receptors in Rat Brain to Phosphoinositide Turnover

1987 • 79 citations

Structure and mechanism of inositol monophosphatase

1995 • 79 citations

Inositol lipids in cellular signalling mechanisms

1992 • 75 citations

Autoradiographic Imaging of Phosphoinositide Turnover in the Brain

1990 • 71 citations

Cloning and expression of human brain type I inositol 1,4,5‐trisphosphate 5‐phosphatase High levels of mRNA in cerebellar Purkinje cells

1994 • 70 citations

Lithium and myo-inositol homeostasis

1993 • 68 citations

Inositol treatment raises CSF inositol levels

1993 • 65 citations

Purification and properties of myo-inositol-1-phosphatase from bovine brain

1988 • 63 citations

24-Hour lithium concentration in human brain studied by Li-7 magnetic resonance spectroscopy

1994 • 57 citations

Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig

1992 • 57 citations

Chronically Administered Lithium Alters Neither myo‐Inositol Monophosphatase Activity nor Phosphoinositide Levels in Rat Brain

1989 • 55 citations

Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase

1994 • 52 citations

Regional development of carbachol-, glutamate-, norepinephrine-, and serotonin-stimulated phosphoinositide metabolism in rat brain

1991 • 47 citations

Localized ¹³C NMR spectroscopy of myo‐inositol in the human brain in vivo

1992 • 47 citations

Inositol triphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures

1992 • 44 citations

The effects of acute and chronic lithium treatment on pilocarpine‐stimulated phosphoinositide hydrolysis in mouse brain in vivo

1990 • 41 citations

Lithium Enhances Accumulation of [³H]Inositol Radioactivity and Mass of Second Messenger Inositol 1,4,5‐Trisphosphate in Monkey Cerebral Cortex Slices

1992 • 37 citations

Inositol 1,4,5-Trisphosphate 3-Kinase mRNA: High Levels in the Rat Hippocampal CA1 Pyramidal and Dentate Gyrus Granule Cells and in Cerebellar Purkinje Cells

1991 • 37 citations

Inositol 6 g daily may be effective in depression but not in schizophrenia

1993 • 35 citations

Developmental and Regional Studies of the Metabolism of Inositol 1,4,5‐Trisphosphate in Rat Brain

1990 • 33 citations

Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium

1990 • 28 citations

Toward a crystal-clear view of lithium's site of action.

1994 • 26 citations

myo-Inositol Monophosphatase from Rat Testes: Purification and Properties

1993 • 21 citations

Raised monophosphatase activity in schizophrenic patients

1992 • 20 citations

Relationship between Plasma, RBC, and CSF Lithium Concentrations in Human Subjects

1979 • 20 citations

Distribution of the neurons containing inositol 1,4,5‐trisphosphate 3‐kinase and its messenger RNA in the developing rat brain

1993 • 17 citations

Ontogenesis of quisqualate‐associated phosphoinositide metabolism in various regions of the rat nervous system

1994 • 16 citations

Inhibitors of inositol monophosphatase

1994 • 14 citations

Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus

1994 • 13 citations

Characterization of inositol monophosphatase in human cerebrospinal fluid

1993 • 12 citations

Lithium increases accumulation of second messenger inositol 1,4,5-triphosphate in brain cortex slices in species ranging from mouse to monkey

1993 • 7 citations

Decreased CSF inositol monophosphatase activity after lithium treatment

1994 • 7 citations