The Potential Mechanism of Induction of Inducible Nitric Oxide Synthase mRNA in Alveolar Macrophages by Lipopolysaccharide and Its Suppression by Ethanol, In Vivo

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Endotoxin signal transduction in macrophages

1996 • 803 citations

Nitric Oxide: A New Paradigm for Second Messengers

1995 • 566 citations

STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

1997 • 534 citations

Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

1996 • 532 citations

Nitric oxide synthase: expression and expressional control of the three isoforms

1995 • 479 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Cytokines of the Lung

1990 • 443 citations

Cellular and molecular neuroscience of alcoholism

1997 • 422 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Initiation of acute phase response and synthesis of cytokines

1996 • 338 citations

The ER-overload response: activation of NF-κB

1997 • 334 citations

Activation of purified guanylate cyclase by nitric oxide requires heme comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

1982 • 262 citations

Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin

1992 • 254 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells.

1991 • 195 citations

Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from l-arginine by macrophages and hepatocytes

1990 • 183 citations

Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine

1992 • 181 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Host Defenses During Prolonged Alcohol Consumption in a Controlled Environment

1977 • 158 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Cytokines activate the nuclear factor κB (NF‐κB) and induce nitric oxide production in human pancreatic islets

1996 • 106 citations

PHOSPHATIDYLETHANOL FORMATION: SPECIFIC EFFECTS OF ETHANOL MEDIATED VIA PHOSPHOLIPASE D

1995 • 105 citations

Restoration of tRNA -primed( )-Strand DNA Synthesis to an HIV-1 Reverse Transcriptase Mutant with Extended tRNAs

1996 • 98 citations

Precision Substrate Targeting of Protein Kinases

1996 • 97 citations

Regulation of Src Family Tyrosine Kinase Activities in Adherent Human Neutrophils

1996 • 93 citations

Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation

1996 • 90 citations

Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages

1992 • 79 citations

Differential effects of in vivo ethanol on LPS-induced TNF and nitric oxide production in the lung

1995 • 75 citations

Ethanol can inhibit nitric oxide production

1992 • 72 citations

Ethanol relaxes pulmonary artery by release of prostaglandin and nitric oxide

1993 • 70 citations

Pharmacological regulation of AP‐1 transcription factor DNA binding activity ¹

1994 • 67 citations

Protein-tyrosine Kinase Activation Is Required for Lipopolysaccharide Induction of Interleukin 1β and NFκB Activation, but Not NFκB Nuclear Translocation

1996 • 66 citations

Alcohol and the lung

1977 • 65 citations

Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine—Inhibition by calcium, lanthanum, and other cations, enhancement by thiols

1980 • 65 citations

Protein Kinase C Participates in Up‐Regulation of Dihydropyridine‐Sensitive Calcium Channels by Ethanol

1990 • 62 citations

Effects of Ethanol on Cellular Immunity to Facultative Intracellular Bacteria

1995 • 62 citations

Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line

1995 • 56 citations

The Alcohol Withdrawal “Kindling” Phenomenon: Clinical and Experimental Findings

1996 • 56 citations

Independent suppression of nitric oxide and TNFα in the lung of conscious rats by ethanol ¹

1995 • 56 citations

The source of non-heme iron that binds nitric oxide in cultivated macrophages

1992 • 55 citations

Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment

1997 • 51 citations

Ethanol suppresses LPS-induced mRNA for nitric oxide synthase II in alveolar macrophages in vivo and in vitro

1994 • 48 citations

Regulation of neuronal nitric oxide synthase by chronic ethanol ingestion

1995 • 38 citations

Diseases and drug-related interventions affecting host defence

1993 • 37 citations

Protein kinase C activation inhibits cytokine-induced nitric oxide synthesis in vascular smooth muscle cells

1994 • 37 citations

The effects of chronic ethanol treatment on endothelium-dependent responses in rat thoracic aorta

1990 • 37 citations

Signaling events in monocytes and macrophages.

1995 • 36 citations

Ethanol causes decrements in airway excretion of endogenous nitric oxide in humans

1994 • 33 citations

Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo.

1997 • 28 citations

Escherichia coli-induced inhibition of endothelium-dependent relaxation and gene expression and release of nitric oxide is attenuated by chronic alcohol ingestion

1994 • 28 citations

Protein Kinase C: Molecular and Cellular Targets for the Action of Ethanol

1996 • 28 citations

Development of Tolerance to Inhibitory Effect of Ethanol on Endothelium‐dependent Vascular Relaxation in Ethanol‐fed Rats

1991 • 24 citations

Ethanol Suppresses Mycobacteria tuberculosis‐Induced mRNA for Nitric Oxide Synthase in Alveolar Macrophages, In Vivo

1995 • 23 citations

Effects of Ethanol Consumption on Susceptibility to Pulmonary and Gastrointestinal Infections

1996 • 20 citations

Cycloheximide induces nitric oxide synthase mRNA in vascular smooth muscle cells by prolonging mRNA lifetime.

1995 • 19 citations

Endothelium‐Dependent Tolerance to Ethanol‐Induced Contraction of Rat Aorta: Effect of Inhibition of EDRF Action and Nitric Oxide Synthesis

1992 • 19 citations

Pulmonary Host Defenses

1995 • 18 citations

Ethanol-Induced Suppression of in Vivo Host Defense Mechanisms to Bacterial Infection

1993 • 17 citations

Anin VivoCytokine and Endotoxin-Independent Pathway for Induction of Nitric Oxide Synthase II mRNA, Enzyme, and Nitrate/Nitrite in Alveolar Macrophages

1996 • 16 citations

TPA and cycloheximide modulate the activation of NF‐κB and the induction and stability of nitric oxide synthase transcript in primary neonatal rat hepatocytes

1996 • 16 citations

NF‐kB, a Prototypical Cytokine‐Regulated Transcription Factor: Implications for Alcohol‐Mediated Responses

1996 • 13 citations

Alcohol and Tyrosine Kinase/Phosphatase Mediated Processes

1996 • 11 citations

Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.

1997 • 4 citations