T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Human naive and memory T cells

1988 • 793 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies.

1988 • 569 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

1983 • 417 citations

Multiple Sclerosis

1982 • 415 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis

1985 • 307 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation

1985 • 241 citations

Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis

1987 • 240 citations

Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis

1983 • 233 citations

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

1988 • 218 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

1986 • 206 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Stimulation of endothelial cell binding of lymphocytes by tumor necrosis factor.

1987 • 197 citations

Amplification and Molecular Cloning of HTLV-I Sequences from DNA of Multiple Sclerosis Patients

1989 • 184 citations

Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.

1989 • 183 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis.

1986 • 169 citations

Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development

1987 • 169 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

1989 • 158 citations

Major histocompatibility complex-linked control of the murine immune response to myelin basic protein.

1985 • 154 citations

Human gamma interferon increases the binding of T lymphocytes to endothelial cells.

1985 • 148 citations

The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

1989 • 147 citations

Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions

1988 • 142 citations

In Vitro Cell-Mediated Immunity of Cerebrospinal-Fluid Lymphocytes to Myelin Basic Protein in Primary Demyelinating Diseases

1977 • 142 citations

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

1988 • 132 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

Selective loss of a subset of T helper cells in active multiple sclerosis.

1985 • 120 citations

Immunotherapy of multiple sclerosis

1988 • 113 citations

Tumor necrosis factor amplifies measles virus-mediated Ia induction on astrocytes.

1987 • 111 citations

Human disease: Mechanisms in multiple sclerosis

1985 • 100 citations

VIRAL INFECTION IN PATIENTS WITH MULTIPLE SCLEROSIS AND HLA-DR MATCHED CONTROLS

1986 • 99 citations

The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes.

1985 • 97 citations

Clonal analysis of functionally distinct human CD4+ T cell subsets.

1988 • 93 citations

In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis

1987 • 90 citations

Intrathecal antibody synthesis to virus antigens in multiple sclerosis.

1983 • 83 citations

The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.

1988 • 82 citations

Structure of t cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis

1988 • 78 citations

CSF cells in multiple sclerosis

1983 • 76 citations

The interferon-macrophage alliance.

1987 • 74 citations

HLA‐DP antigens are involved in the susceptibility to multiple sclerosis

1988 • 71 citations

GENETIC ASPECTS OF MULTIPLE SCLEROSIS

1953 • 63 citations

Clonal analysis of HLA-restricted virus-specific cytotoxic T lymphocytes from cerebrospinal fluid in mumps meningitis.

1983 • 55 citations

Inducible expression of h-2 and ia antigens on brain cells

1985 • 49 citations

The role of self-antigen in the development of autoimmunity in Obese strain chickens with spontaneous autoallergic thyroiditis.

1982 • 48 citations

Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

1986 • 45 citations

Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.

1986 • 42 citations

Increased proportion of CD4+ CDw29+ CD45R− UCHL-1+ lymphocytes in the cerebrospinal fluid of both multiple sclerosis patients and healthy individuals

1989 • 42 citations

Viral antibodies in twins with multiple sclerosis

1985 • 41 citations

T cell subsets in multiple sclerosis. A longitudinal study of exacerbating-remitting cases.

1985 • 37 citations

Prostaglandin levels in cerebrospinal fluid from multiple sclerosis patients in remission and relapse

1984 • 36 citations

Derivation of ganglioside-specific T cell lines of suppressor or helper phenotype from cerebrospinal fluid of multiple sclerosis patients

1986 • 30 citations

IL-2 receptor and HLA class II antigens on cerebrospinal fluid cells of patients with multiple sclerosis and other neurological diseases.

1987 • 29 citations

Phenotypic markers and functional characteristics of T lymphocyte clones from cerebrospinal fluid in multiple sclerosis

1984 • 29 citations

Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations

1985 • 28 citations

Myelin basic protein-specific CD4+ cytolytic T-lymphocyte clones isolated from multiple sclerosis patients

1988 • 27 citations

Role of T Helper Lymphocytes in Autoimmune Diseases

1989 • 24 citations

Analysis of T cell receptor-gene rearrangement in T cells from the cerebrospinal fluid of patients with multiple sclerosis

1987 • 21 citations

Relationship to a retrovirus?

1989 • 21 citations

Antigen-specific T cells can mediate demyelination in organotypic central nervous system cultures

1986 • 19 citations

The role of antigen in autoimmune responses with special reference to changes in carbohydrate structure of IgG in rheumatoid arthritis

1988 • 19 citations

T-cell subsets in spinal fluid of multiple sclerosis patients

1984 • 17 citations

Myelin basic protein‐responsive blood T lymphocytes in patients with multiple sclerosis

1985 • 15 citations

Biology of Disease Role of T Helper Lymphocytes in Autoimmune Diseases

1989 • 14 citations

Network regulation in rheumatoid arthritis. studies of dr+ t cells, anti‐dr, antiidiotypic antibodies, and clinical disease activity

1988 • 11 citations

Relative increase of inflammatory CD4+ T cells in the cerebrospinal fluid of multiple sclerosis patients and control individuals

1990 • 11 citations

Longitudinal analysis of three intrathecally produced immunoglobulin subpopulations in an MS patient.

1985 • 10 citations

Advances in neuroimmunology

1988 • 8 citations

Tetanus Toxoid Reactive T Lymphocytes in the Cerebrospinal Fluid of Multiple Sclerosis Patients

1984 • 8 citations

Cell‐Mediated Immunity in Virus Infections of the Central Nervous System

1988 • 3 citations

[Expression of interleukin 2 receptor and class II histocompatibility antigens on lymphocytes of the cerebrospinal fluid in patients with multiple sclerosis and other neurological diseases].

1987 • 3 citations