Clinical transplantation tolerance: The promise and challenges

Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996

2000 • 1,803 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection

1998 • 585 citations

Heterologous immunity provides a potent barrier to transplantation tolerance

2003 • 565 citations

Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

1995 • 552 citations

Heterologous immunity provides a potent barrier to transplantation tolerance

2003 • 534 citations

Tolerogenic immunosuppression for organ transplantation

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Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Immunosuppressive strategies in transplantation

1999 • 461 citations

COMBINED HISTOCOMPATIBILITY LEUKOCYTE ANTIGENMATCHED DONOR BONE MARROW AND RENAL TRANSPLANTATION FOR MULTIPLE MYELOMA WITH END STAGE RENAL DISEASE: THE INDUCTION OF ALLOGRAFT TOLERANCE THROUGH MIXED LYMPHOHEMATOPOIETIC CHIMERISM

1999 • 418 citations

Mixed Chimerism and Transplant Tolerance

2001 • 391 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

Dendritic Cells in Transplantation—Friend or Foe?

2001 • 282 citations

Immunologic Tolerance to Renal Allografts after Bone Marrow Transplants from the Same Donors

1991 • 266 citations

Human allograft acceptance is associated with immune regulation

2000 • 261 citations

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

1993 • 251 citations

Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

2003 • 232 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

Control of lymphocyte function through CD27–CD70 interactions

1998 • 219 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo

2003 • 190 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

1995 • 186 citations

Acquired Immune Tolerance to Cadaveric Renal Allografts

1989 • 185 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

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Chronic allograft dysfunction: mechanisms and new approaches to therapy.

2000 • 128 citations

CLINICAL TRANSPLANTATION TOLERANCE TWELVE YEARS AFTER PROSPECTIVE WITHDRAWAL OF IMMUNOSUPPRESSIVE DRUGS: STUDIES OF CHIMERISM AND ANTI-DONOR REACTIVITY1

2000 • 128 citations

DENDRITIC CELLS AS REGULATORS OF IMMUNE REACTIVITY: IMPLICATIONS FOR TRANSPLANTATION1

1999 • 119 citations

CD28-independent Costimulation of T Cells in Alloimmune Responses

2001 • 117 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

Challenges to achieving clinical transplantation tolerance

2001 • 111 citations

New Insights Into the Interactions Between T-Cell Costimulatory Blockade and Conventional Immunosuppressive Drugs

2002 • 97 citations

Challenges to achieving clinical transplantation tolerance

2001 • 96 citations

Transplantation Tolerance: A Look at the Nonhuman Primate Literature in the Light of Modern Tolerance Theories

1999 • 91 citations

EVIDENCE THAT IMPROVED LATE RENAL TRANSPLANT OUTCOME CORRELATES WITH THE DEVELOPMENT OF IN VITRO DONOR ANTIGEN-SPECIFIC HYPOREACTIVITY

1993 • 88 citations

Clinical Trials of Transplant Tolerance: Slow But Steady Progress

2003 • 88 citations

In Search of the Elusive Holy Grail: the Mechanisms and Prospects for Achieving Clinical Transplantation Tolerance

2001 • 82 citations

CTLA4Ig Gene Transfer Prolongs Survival and Induces Donor-Specific Tolerance in a Rat Renal Allograft

2000 • 68 citations

Transplantation tolerance: The concept and its applicability

1999 • 44 citations

Tolerance and chronic rejection

2001 • 38 citations

Prospects and applicability of molecular diagnosis of allograft rejection.

2000 • 36 citations

Viral Infection Abrogates CD8+ T-cell Deletion Induced by Costimulation Blockade

2000 • 32 citations

The role of costimulatory molecules as targets for new immunosuppressives in transplantation

2000 • 31 citations

Transplantation tolerance: fooling mother nature.

1996 • 29 citations

The Allocation of Cadaver Kidneys for Transplantation in the United States

1999 • 28 citations

Of Mice and Means

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Induction of tolerance to alloantigen.

1999 • 9 citations