Function of the Human Insulin Promoter in Primary Cultured Islet Cells

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

1983 • 883 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

1990 • 603 citations

Sequence of the human insulin gene

1980 • 553 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

1995 • 383 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates.

1993 • 209 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP

1992 • 183 citations

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

1986 • 178 citations

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.

1993 • 177 citations

Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture

1989 • 176 citations

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures.

1990 • 174 citations

The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.

1992 • 168 citations

Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.

1992 • 165 citations

Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

1992 • 162 citations

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

1990 • 156 citations

Elusive Proximal Signals of β-Cells for Insulin Secretion

1990 • 151 citations

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1991 • 150 citations

The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose

1994 • 145 citations

Nutrient regulation of insulin gene expression

1994 • 142 citations

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.

1992 • 139 citations

Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family

1993 • 138 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type.

1993 • 126 citations

Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

1989 • 123 citations

Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression

1994 • 118 citations

Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells.

1992 • 113 citations

Upstream Stimulatory Factor Proteins Are Major Components of the Glucose Response Complex of the L-type Pyruvate Kinase Gene Promoter

1995 • 109 citations

c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.

1992 • 109 citations

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines.

1993 • 102 citations

Human Islet Amyloid Polypeptide Gene: Complete Nucleotide Sequence, Chromosomal Localization, and Evolutionary History

1989 • 98 citations

A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer

1989 • 85 citations

Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β cells and lymphocytes

1991 • 84 citations

Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes.

1992 • 75 citations

Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells.

1992 • 65 citations

Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter.

1992 • 55 citations

Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40‐transformed B cells

1987 • 54 citations

Analysis of a 1963-bp polymorphic region flanking the human insulin gene

1984 • 48 citations

Subunit structure of cell-specific E box-binding proteins analyzed by quantitation of electrophoretic mobility shift.

1992 • 45 citations

cis-acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue-specific activators and extinguisher.

1991 • 41 citations

Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.

1991 • 38 citations

Expression of liver type pyruvate kinase in insulinoma cells: Involvement of LF-B1 (HNF1)

1991 • 36 citations

NOTES/Insulin Gene Expression in Nonexpressing Cells Appears To Be Regulated by Multiple Distinct Negative-Acting Control Elements

1991 • 29 citations

Pancreatic islets contain the M2 isoenzyme of pyruvate kinase its phosphorylation has no effect on enzyme activity

1985 • 28 citations

Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies.

1992 • 26 citations

Negative regulation of human insulin gene expression by the 5′‐flanking region in non‐pancreatic cells

1989 • 25 citations

Effects of Glucose on Insulin Secretion, Glucokinase Activity, and Transgene Expression in Transgenic Mouse Islets Containing an Upstream Glucokinase Promoter-Human Growth Hormone Fusion Gene

1994 • 20 citations

Characterization of the promoter-regulatory region and structural organization of E1 alpha gene (BCKDHA) of human branched-chain alpha-keto acid dehydrogenase complex.

1993 • 18 citations