The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

An Alternate Promoter in the Glucokinase Gene Is Active in the Pancreatic β Cell

1989 • 210 citations

Characterization of the two nonallelic genes encoding mouse preproinsulin

1986 • 165 citations

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

1990 • 156 citations

INSULIN BIOSYNTHESIS IN THE RAT: DEMONSTRATION OF TWO PROINSULINS

1969 • 155 citations

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1991 • 150 citations

Cell-specific enhancers in the rat exocrine pancreas.

1986 • 150 citations

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

1991 • 150 citations

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

1988 • 142 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

1989 • 123 citations

Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells.

1989 • 121 citations

Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells

1991 • 116 citations

EXPRESSION OF THE RAT AMYLIN (IAPP / DAP) GENE.

1989 • 116 citations

Human Islet Amyloid Polypeptide Gene: Complete Nucleotide Sequence, Chromosomal Localization, and Evolutionary History

1989 • 98 citations

Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators

1988 • 98 citations

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer.

1988 • 95 citations

Identification of a Pancreatic β-Cell Insulin Gene Transcription Factor That Binds to and Appears To Activate Cell-Type-Specific Expression: Its Possible Relationship to Other Cellular Factors That Bind to a Common Insulin Gene Sequence

1990 • 94 citations

A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene

1990 • 91 citations

Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration

1989 • 89 citations

Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription.

1989 • 86 citations

Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β cells and lymphocytes

1991 • 84 citations

Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells

1991 • 80 citations

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

1985 • 68 citations

Islet cell-specific regulatory domain in the gastrin promoter contains adjacent positive and negative DNA elements.

1990 • 66 citations

Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene.

1990 • 56 citations

IAPP/amylin gene transcriptional control region: evidence for negative regulation

1990 • 26 citations