Negative regulation of human insulin gene expression by the 5′‐flanking region in non‐pancreatic cells

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Sequence and Structure of a Human Glucose Transporter

1985 • 1,557 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

An exonuclease protection assay reveals heat-shock element and TATA box DNA-binding proteins in crude nuclear extracts

1985 • 280 citations

STRUCTURE AND EVOLUTION OF THE INSULIN GENE

1985 • 252 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA.

1985 • 196 citations

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

1986 • 178 citations

Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators

1988 • 98 citations

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer.

1988 • 95 citations

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

1987 • 90 citations

Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators.

1988 • 55 citations

Modulation of Insulin Secretion From β-Cells by Phosphoinositide-Derived Second-Messenger Molecules

1988 • 33 citations

Sequence of a New World primate insulin having low biological potency and immunoreactivity.

1987 • 27 citations