Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

1981 • 381 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

RNA-Mediated Gene Duplication: the Rat Preproinsulin I Gene Is a Functional Retroposon

1985 • 256 citations

STRUCTURE AND EVOLUTION OF THE INSULIN GENE

1985 • 252 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

1990 • 156 citations

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

1991 • 150 citations

Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

1989 • 123 citations

Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells.

1989 • 121 citations

Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators

1988 • 98 citations

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer.

1988 • 95 citations

Identification of a Pancreatic β-Cell Insulin Gene Transcription Factor That Binds to and Appears To Activate Cell-Type-Specific Expression: Its Possible Relationship to Other Cellular Factors That Bind to a Common Insulin Gene Sequence

1990 • 94 citations

A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene

1990 • 91 citations

Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription.

1989 • 86 citations

A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer

1989 • 85 citations

The COUP Transcription Factor Binds to an Upstream Promoter Element of the Rat Insulin II Gene

1988 • 80 citations

Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene.

1990 • 56 citations

The two nonallelic rat insulin mRNAs and pre-mRNAs are regulated coordinately in vivo.

1988 • 43 citations

A Steroid Response Element Can Function in the Absence of a Distal Promoter

1988 • 25 citations

Insulin enhancer binding protein has helix-loop-helix structure

1990 • 24 citations