Interferon-β Interrupts Interleukin-6–Dependent Signaling Events in Myeloma Cells

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

The pathway to signal achievement

1993 • 563 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Interleukin-6 in human multiple myeloma

1995 • 550 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

The ins and outs of Raf kinases

1994 • 537 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

1994 • 304 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1989 • 271 citations

14-3-3 proteins on the MAP

1995 • 255 citations

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

1993 • 214 citations

Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL.

1995 • 200 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

1994 • 187 citations

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

1992 • 185 citations

Transcriptional regulation of interferon‐stimulated genes

1991 • 184 citations

Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266

1991 • 177 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.

1991 • 147 citations

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.

1994 • 136 citations

JAK protein tyrosine kinases: their role in cytokine signalling

1994 • 125 citations

Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21

1993 • 113 citations

Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.

1994 • 105 citations

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1995 • 99 citations

Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.

1993 • 88 citations

Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.

1994 • 87 citations

Networking with mitogen-activated protein kinases

1993 • 65 citations

Syp Associates with gp130 and Janus Kinase 2 in Response to Interleukin-11 in 3T3-L1 Mouse Preadipocytes

1995 • 63 citations

Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains.

1994 • 59 citations

Tyrosine Phosphorylation of Jak-Tyk Kinases in Malignant Plasma Cell Lines Growth Stimulated by Interleukins 6 and 11

1994 • 51 citations

Suppression of programmed death and G₁ arrest in B‐cell hybridomas by interleukin‐6 is not accompanied by altered expression of immediate early response genes

1990 • 41 citations

The effect of α and γ‐interferon on proliferation and production of IgE and β₂‐microglobulin in the human myeloma cell line U‐266 and in an α‐interferon resistant U‐266 subline

1986 • 26 citations

Interferon-α down-regulates the interleukin-6 receptor in a human multiple myeloma cell line, U266

1995 • 24 citations

Hematopathology of interleukin 6-type cytokines.

1994 • 20 citations

Biology and treatment of multiple myeloma

1992 • 19 citations

Blockage of the Early Events of Mitogenic Signaling by Interferon-γ in Macrophages in Response to Colony-Stimulating Factor-1

1995 • 19 citations

Modified glutathione S-transferase fusion proteins for simplified analysis of protein - protein interactions

1993 • 14 citations