In Vivo Evidence of an Endothelin-Induced Vasopressor Tone After Inhibition of Nitric Oxide Synthesis in Rats

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Molecular characterization of endothelin receptors

1992 • 601 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.

1994 • 521 citations

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

1993 • 445 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Regional and cardiac haemodynamic effects of N^G‐nitro‐<scp>l</scp>‐arginine methyl ester in conscious, Long Evans rats

1990 • 268 citations

Presence of immunoreactive endothelin in human plasma

1989 • 258 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells

1990 • 148 citations

Inhibition of endothelium-derived relaxing factor enhances endothelin-mediated vasoconstriction.

1992 • 128 citations

Endothelin in hypertensive resistance arteries. Intraluminal and extraluminal dysfunction.

1991 • 122 citations

Differential sensitivity to endothelin in canine arteries and veins

1989 • 104 citations

Endothelium-derived relaxing factor modulates endothelin action in afferent arterioles.

1991 • 79 citations

Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells.

1991 • 78 citations

Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor

1993 • 75 citations

Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.

1991 • 69 citations

Pressor and renal vasoconstrictor effects of NG-nitro-L-arginine as affected by blockade of pressor mechanisms mediated by the sympathetic nervous system, angiotensin, prostanoids and vasopressin.

1992 • 60 citations

Sympathetic modulation of endothelium-derived relaxing factor.

1992 • 47 citations

Antihypertensive Effects of the Endothelin Receptor Antagonist BQ-123 in Conscious Spontaneously Hypertensive Rats

1993 • 47 citations

Radioimmunological Determination of Endothelin Peptides in Human Plasma: A Methodological Approach

1994 • 39 citations

Differential Effect of Cyclic GMP on the Release of Endothelin-1 from Cultured Endothelial Cells and Intact Porcine Aorta

1991 • 30 citations

Incomplete inhibition of endothelin-1 pressor effects by an endothelin ETA receptor antagonist

1993 • 21 citations