Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Modulation of Vascular Smooth Muscle Contraction by the Endothelium

1986 • 643 citations

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica

1980 • 615 citations

Single‐channel recordings of three types of calcium channels in chick sensory neurones.

1987 • 563 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1986 • 397 citations

PINOCYTOSIS IN FIBROBLASTS

1974 • 389 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery

1984 • 389 citations

Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain

1988 • 362 citations

Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

1989 • 346 citations

Molecular mechanism of action of the vasoconstrictor peptide endothelin

1988 • 317 citations

Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells

1989 • 304 citations

Endothelin-1 and Endothelin-3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit

1989 • 302 citations

Plasma immunoreactive endothelin in essential hypertension

1990 • 302 citations

Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.

1981 • 300 citations

The influence of basic residues on the substrate specificity of protein kinase C.

1987 • 287 citations

Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat

1989 • 260 citations

Nitroglycerin Stimulates Synthesis of Prostacyclin by Cultured Human Endothelial Cells

1981 • 252 citations

Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells

1988 • 241 citations

Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells

1989 • 230 citations

Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin production

1988 • 190 citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

1989 • 176 citations

The Human Preproendothelin-1 Gene

1989 • 166 citations

Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols

1989 • 154 citations

Endothelium‐derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells

1988 • 130 citations

Two different forms of endothelin receptors in rat lung

1989 • 117 citations

Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester‐sensitive pathway

1988 • 117 citations

Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

1990 • 104 citations

Stimulation of cyclic GMP production in cultured endothelial cells of the pig by bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide

1990 • 96 citations

Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells

1989 • 92 citations

Endothelin-1 activates phospholipase C and mobilizes Ca2+ from extra- and intracellular pools in osteoblastic cells

1989 • 84 citations

Endothelin stimulates the release of prostacyclin from rat mesenteric arteries

1989 • 79 citations

Inositol phosphate production and Ca2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine

1988 • 66 citations

Prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats

1989 • 59 citations

Modulation of Vascular Smooth Muscle Contraction by the Endothelium

1986 • 57 citations

Enhanced responsiveness to angiotensin II in vascular smooth muscle cells from spontaneously hypertensive rats is not associated with alterations in protein kinase C.

1989 • 48 citations

Endothelin-1 Stimulates Phosphatidylinositol Hydrolysis and Calcium Uptake in Isolated Canine Coronary Arteries

1989 • 43 citations

Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses

1988 • 40 citations

Measurement of intracellular calcium concentration in intact monolayers of human endothelial cells.

1988 • 39 citations

Release of immunoreactive endothelin from porcine aortic strips.

1990 • 35 citations

Stimulation of cell growth and inhibition of prostacyclin production by heparin in human umbilical vein endothelial cells

1988 • 31 citations

Acute Effects of Endothelin on Renal Hemodynamics and Blood Pressure in Anesthetized Rats

1989 • 30 citations

Increased thromboxane B₂ biosynthesis in platelets

1982 • 29 citations

Endothelin and eicosanoid synthesis in cultured mesangial cells

1990 • 28 citations

Renal Prostaglandins and Phospholipase A2 in Spontaneously Hypertensive Rats

1987 • 26 citations

Effect of endothelin-1 on cytosolic calcium ions in cultured human endothelial cells

1990 • 22 citations