Vitamin E: Focus on Microcirculation

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.

1991 • 477 citations

Free radicals in diabetic endothelial cell dysfunction

1994 • 398 citations

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

1994 • 365 citations

Role of oxygen-derived free radicals in digestive tract diseases.

1983 • 362 citations

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

1996 • 344 citations

Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage.

1994 • 328 citations

Serial Coronary Angiographic Evidence That Antioxidant Vitamin Intake Reduces Progression of Coronary Artery Atherosclerosis

1995 • 327 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

Role of free radicals in ischemic rat liver cell injury: prevention of damage by alpha-tocopherol administration.

1986 • 276 citations

Microvascular ischemia-reperfusion injury in striated muscle: significance of "reflow paradox"

1992 • 270 citations

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.

1996 • 251 citations

Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease

1993 • 245 citations

Reduced risk of colon cancer with high intake of vitamin E : the Iowa Women's Health Study.

1993 • 237 citations

A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alpha-tocopherol administration.

1983 • 214 citations

Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.

1994 • 213 citations

Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster.

1991 • 212 citations

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

1993 • 204 citations

Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation.

1993 • 199 citations

Microvascular ischemia-reperfusion injury in striated muscle: significance of "no reflow"

1992 • 175 citations

Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

1994 • 173 citations

Vitamin E inhibits protein kinase c activity

1988 • 169 citations

Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.

1994 • 167 citations

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1995 • 158 citations

Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant

1995 • 157 citations

Role of oxygen-derived free radicals in digestive tract diseases

1984 • 157 citations

Vitamin E inhibits platelet phospholipase A2

1986 • 149 citations

Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta

1995 • 138 citations

Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status

1991 • 124 citations

Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability

1985 • 121 citations

Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells.

1996 • 119 citations

Linoleic acid activates nuclear transcription factor-κB (NF-κB) and induces NF-κB-dependent transcription in cultured endothelial cells

1996 • 108 citations

Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E

1982 • 108 citations

Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation

1994 • 105 citations

A multivitamin infusion prevents lipid peroxidation and improves transplantation performance

1993 • 105 citations

Vitamin E and coronary heart disease: the European paradox.

1994 • 97 citations

Superoxide generation during cardiopulmonary bypass: Is there a role for vitamin E?

1986 • 96 citations

Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes

1980 • 93 citations

Lymphocyte Adherence in the Reperfused Rat Liver: Mechanisms and Effects

1993 • 89 citations

Probucol prevents oxidative injury to endothelial cells.

1991 • 85 citations

Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells

1991 • 78 citations

alpha-Tocopherol attenuates myocardial membrane-related alterations resulting from ischemia and reperfusion

1989 • 71 citations

Alterations of the Eicosanoid Synthetic Capacity of Rat Brain Microvessels Following Ischemia: Relevance to Ischemic Brain Edema

1985 • 64 citations

Vitamin E in gastric mucosal injury induced by ischemia-reperfusion

1991 • 63 citations

Effects of alpha-tocopherol administration on red blood cell membrane lipid peroxidation in hemodialysis patients.

1984 • 61 citations

Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation

1994 • 60 citations

Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity

1994 • 60 citations

Antioxidants and antioxidant enzymes protect against pulmonary oxygen toxicity in the rabbit

1990 • 55 citations

PROTECTIVE EFFECTS OF α-TOCOPHEROL AND COENZYME Q10 ON WARM ISCHEMIC DAMAGES OF THE RAT KIDNEY

1981 • 54 citations

Protective effect of vitamin E on linoleic acid hydroperoxide-induced injury to human endothelial cells

1991 • 54 citations

The influence of vitamin E quinone on platelet structure, function, and biochemistry

1980 • 54 citations

Cardiac Recovery during Postischemic Reperfusion Is Improved by Combination of Vitamin E with Dihydrolipoic Acid

1993 • 52 citations

Alpha Tocopherol Improves Focal Glomerulosclerosis in Rats with Adriamycin-lnduced Progressive Renal Failure

1994 • 51 citations

Comparative study of oxygen toxicity in human fibroblasts and endothelial cells

1990 • 50 citations

Protective effect of liposome-associated α-tocopherol against paraquat-induced acute lung toxicity

1992 • 50 citations

Dietary fish oil blocks the microcirculatory manifestations of ischemia-reperfusion injury in striated muscle in hamsters.

1991 • 49 citations

Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate

1983 • 48 citations

Vitamin E exerts antiaggregatory effects without inhibiting the enzymes of the arachidonic acid cascade in platelets

1986 • 43 citations

The effect of glutathione and vitamins A, C, and E on acute skin flap survival

1987 • 43 citations

Reduction of platelet adhesiveness by vitamin E supplementation in humans

1988 • 43 citations

Effects of dietary vitamin E on the biosynthesis of 5-lipoxygenase products by rat polymorphonuclear leukocytes (PMNL)

1989 • 42 citations

Effect of vitamin E on acute iron load-potentiated aggregation, secretion, calcium uptake and thromboxane biosynthesis in rat platelets

1992 • 40 citations

Vitamin E prevents endothelial injury associated with cisplatin injection into the superior mesenteric artery of rats

1995 • 39 citations

Regulation by vitamin E of phosphatidylcholine metabolism in rat heart

1987 • 39 citations

The protective effect of vitamin E on cerebral ischemia

1984 • 39 citations

Effect of Free-Radical Scavengers and Hyperbaric Oxygen on Random-Pattern Skin Flaps

1994 • 38 citations

Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes

1994 • 37 citations

In vivo inhibition of superoxide production and protein kinase C activity in macrophages from vitamin E-treated rats.

1990 • 37 citations

Vitamin E inhibits the release of calcium from a platelet membrane fraction in vitro

1979 • 37 citations

Effect of Vitamin E on Linoleic Acid-Mediated Induction of Peroxisomal Enzymes in Cultured Porcine Endothelial Cells

1990 • 36 citations

Total Antioxidant Capacity and Lipid Peroxidation during Liver Transplantation

1995 • 36 citations

EXPERIMENTAL AND CLINICAL RESULTS IN SHOCK LUNG TREATMENT WITH VITAMIN E

1982 • 36 citations

Impact of vitamin E supplement in standard laboratory animal diet on microvascular manifestation of ischemia/reperfusion injury

1995 • 36 citations

RATIONALE FOR THE USE OF ANTIOXIDANT VITAMINS IN CLINICAL ORGAN TRANSPLANTATION

1996 • 35 citations

MECHANISM OF ACTION OF VITAMIN E ON PLATELET FUNCTION*

1982 • 35 citations

Inhibitory effect of vitamin E (α -tocopherol) on spontaneous platelet aggregation in whole blood

1990 • 35 citations

Effect of vitamin E on oxysterol- and fatty acid hydroperoxide-induced changes of repair and permeability properties of cultured endothelial cell monolayers.

1988 • 35 citations

Prostacyclin Production in Cultured Endothelial Cells is Highly Sensitive to Low Doses of Ionizing Radiation

1993 • 35 citations

Effect of α-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion

1992 • 34 citations

INHIBITION OF FREE RADICAL GENERATION AND IMPROVED SURVIVAL BY PROTECTION OF THE HEPATIC MICROVASCULAR ENDOTHELIUM BY TARGETED ERYTHROCYTES IN ORTHOTOPIC RAT LIVER TRANSPLANTATION

1990 • 33 citations

Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury

1984 • 33 citations

Impact of leukocyte adhesion on myocardial ischemia/reperfusion injury: conceivable mechanisms and proven facts.

1993 • 33 citations

Reduction of experimental myocardial infarct size by oral administration of tocopherol

1991 • 33 citations

Effect of vitamin E on vascular integrity in cholesterol-fed guinea pigs.

1993 • 32 citations

Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal by Antioxidants

1995 • 32 citations

Mechanism for endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid, an arachidonate lipoxygenase product

1992 • 32 citations

The effect of vitamins C and E on lipid peroxidation in stored erythrocytes.

1993 • 32 citations

Dietary vitamin E increases the resistance to lipoprotein oxidation and attenuates endothelial dysfunction in the cholesterol-fed rabbit

1994 • 31 citations

Vitamin Ε Reduces Bleomycin-Induced Lung Fibrosis in Mice: Biochemical and Morphological Studies

1993 • 30 citations

Influence of dietary vitamin E deficiency on compression injury of rat spinal cord.

1990 • 29 citations

Inverse correlation of vitamin E and ischemic heart disease.

1989 • 28 citations

Prevention of pancreatic islet xenograft rejection by dietary vitamin E.

1997 • 28 citations

Antioxidant Vitamin Supplementation of Smoke-Exposed Rats Partially Protects Against Myocardial Ischaemic/Reperfusion Injury

1992 • 27 citations

THE BENEFICIAL EFFECT OF DIETARY ANTIOXIDANT SUPPLEMENTATION ON PLATELET AGGREGATION AND CYCLOSPORINE TREATMENT IN HEART TRANSPLANT RECIPIENTS

1994 • 26 citations

Effects of vitamin E on endothelium-dependent coronary flow in hypercholesterolemic dogs

1996 • 25 citations

Effects of vitamin E on prostacyclin release and lipid composition of the ischemic rat heart

1990 • 25 citations

An α-tocopherol analogue with antioxydant activity improves myocardial function during ischemia reperfusion in isolated working rat hearts

1993 • 24 citations

Do vitamin E supplements in diets for laboratory animals jeopardize findings in animal models of disease?

1999 • 23 citations

LONG‐TERM STUDY OF α‐TOCOPHEROL IN INTERMITTENT CLAUDICATION

1982 • 23 citations

Reduction of sunburn damage to skin by topical application of vitamin E acetate following exposure to ultraviolet B radiation: effect of delaying application or of reducing concentration of vitamin E acetate applied.

1993 • 23 citations

Multiple Organ Failure: Clinical Implications to Macro- and Microcirculation

1988 • 22 citations

Recovery after dietary vitamin E supplementation of impaired endothelial function in vitamin E‐deficient rats

1994 • 21 citations

Effects of Dietary Supplementation with Vitamin E on Human Neutrophil Chemotaxis and Generation of LTB₄

1991 • 20 citations

Myocardial infarct size reduction by single high dose or repeated low dose vitamin E supplementation in rabbits.

1993 • 19 citations

Arachidonic acid and leukotriene B₄ induce aggregation of human peripheral blood mononuclear leucocytes in vitro

1984 • 18 citations

Effects of CV-3611, a new free radical scavenger, on ischemic heart failure in conscious beagle dogs.

1989 • 17 citations

Preservation of Cortical Microcirculation After Kidney Ischemia-Reperfusion: Value of an Iron Chelator

1994 • 16 citations

Effects of vitamin E on endothelium-dependent coronary flow in hypercholesterolemic dogs

1996 • 16 citations

Rodent model of renal ischemia and reperfusion injury: influence of body temperature, seasonal variation, tumor necrosis factor, endogenous and exogenous antioxidants.

1993 • 15 citations

Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent

1992 • 15 citations

Role of oxygen radicals and synergistic effect of superoxide dismutase and catalase on ischemia-reperfusion injury of the rat pancreas.

1992 • 15 citations

Fluorographic study on the oxidative stress in the process of gastric mucosal injury: Attenuating effect of Vitamin E

1993 • 14 citations

Walking distance and arterial flow during long term treatment of intermittent claudication with d-a-tocopherol.

1973 • 13 citations

Functional and morphological changes in the cochlea of cholesterolfed guinea pigs.

1994 • 12 citations

Vitamin E and vitamin C inhibit arachidonate-induced aggregation of human peripheral blood leukocytesin vitro

1986 • 12 citations

Prevention of platelet dysfunction by vitamin E in diabetic atherosclerosis

1993 • 11 citations

Vitamin E Attenuates the Effects of FMLP on Rabbit Circulating Granulocytes

1984 • 10 citations

Vitamin E. Deficiency increases the synthesis of platelet‐activating factor (PAF) in rat polymorphonuclear leucocytes

1989 • 10 citations

[An experimental study of tissue injury associated with reperfusion in ischemic limbs].

1989 • 9 citations

Oxidized low-density lipoproteins and endothelium: oral vitamin E supplementation prevents oxidized low-density lipoprotein-mediated vascular injury.

1993 • 8 citations

Serum vitamin E and the sickling status in children with sickle cell anaemia.

1990 • 8 citations

Vitamin E enhances prostacyclin production by cultured aortic endothelial cells.

1990 • 7 citations

Effects of Tocotrienol-Rich Vitamin E on Patients with Peripheral Vascular Disease

1992 • 6 citations

The effect of alpha-tocopherol and Intal on heart capillary bed and lipid peroxide oxidation in experimental necrosis of the rat myocardium.

1989 • 5 citations

Drug treatment of changes in platelet-vessel wall interactions in burned rats

1986 • 5 citations

Antihypertensive action of d,l-alpha-tocopheryl nicotinate in rats.

1979 • 3 citations

[Clinical application of fat soluble vitamins to retinopathy of prematurity and intracranial hemorrhage].

1993 • 2 citations

[Changes of the necrotic area and functional indices of the myocardial microcirculatory bed during the treatment of experimental myocardial infarct with nitroglycerin, alpha-tocopherol and sodium nucleinate].

1989 • 2 citations

[Ultrastructural changes in endothelial cells in rabbits with multiple organ failure (MOF)].

1993 • 2 citations

[Effect of alpha-tocopherol on the development of diabetic angiopathy, platelet aggregation and status of the prostacyclin-thromboxane system in rats with streptozotocin diabetes].

1993 • 2 citations

Effect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes

2019 • 2 citations

[Disruption of the permeability of blood-tissue barriers in mechanisms of primary reaction to irradiation].

1995 • 1 citations

[Disorders of pulmonary hemodynamics in patients with diabetic nephroangiopathy and its correction with antioxidants].

1992 • 1 citations