Prostacyclin Production in Cultured Endothelial Cells is Highly Sensitive to Low Doses of Ionizing Radiation

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Transplantation Proceedings

2006 • 1,622 citations

Proceedings of the National Academy of Sciences, USA

1996 • 1,621 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine

1984 • 817 citations

Advances in prostaglandin, thromboxane, and leukotriene research

1985 • 759 citations

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

1977 • 625 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Culture of vascular endothelium.

1976 • 532 citations

The new England journal of medicine

1994 • 527 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing

1983 • 467 citations

Ionizing Radiation and the Immune Response

1976 • 435 citations

Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1

1985 • 364 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

Human Lymphocytes Exposed to Low Doses of Ionizing Radiations Become Refractory to High Doses of Radiation as Well as to Chemical Mutagens that Induce Double-strand Breaks in DNA

1988 • 283 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Advances in Radiation Biology

1975 • 247 citations

Peroxidase-dependent deactivation of prostacyclin synthetase

1979 • 231 citations

Evidence that the [³H]thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism

1986 • 224 citations

Modulation of gene expression in Syrian hamster embryo cells following ionizing radiation.

1990 • 187 citations

Induction of Cytogenetic Adaptive Response of Somatic and Germ Cellsin Vivoandin Vitroby Low-dose X-irradiation

1990 • 186 citations

Progress in Hemostasis and Thrombosis

1977 • 184 citations

Induction of the Adaptive Response by X-rays is Dependent on Radiation Intensity

1989 • 180 citations

Methods for microcarrier culture of bovine pulmonary artery endothelial cells avoiding the use of enzymes

1980 • 180 citations

Variability of the adaptive response to ionizing radiations in humans

1989 • 169 citations

Effect of hydrogen peroxide on prostaglandin production and cellular integrity in cultured porcine aortic endothelial cells.

1985 • 162 citations

Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays

1989 • 153 citations

Radiation Hormesis

1987 • 150 citations

Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

1984 • 140 citations

Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide System

1979 • 136 citations

Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs

1991 • 129 citations

Chromosomal responses to ionizing radiation reminiscent of and adaptive response in cultured Chinese hamster cells

1987 • 128 citations

Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide

1989 • 124 citations

Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells

1982 • 120 citations

Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation

1986 • 118 citations

Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population.

1978 • 118 citations

Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured Chinese hamster cells

1989 • 104 citations

Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta.

1983 • 98 citations

Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period

1993 • 90 citations

Differential Modulation of Specific Gene Expression Following High- and Low-LET Radiations

1990 • 87 citations

Irradiation induces release of von Willebrand protein from endothelial cells in culture

1984 • 77 citations

Chemical Protection against Ionizing Radiation

1987 • 73 citations

Stimulation of prostaglandin synthesis by ascorbic acid via hydrogen peroxide formation

1980 • 70 citations

Indications of an adaptive response in C57BL mice pre-exposed in vivo to low doses of ionizing radiation

1990 • 70 citations

Radiation tolerance of normal tissues

1989 • 69 citations

Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta

1985 • 69 citations

The effect of radiation on prostacycliln (PG2) productnio by cultured endothelial cells

1983 • 67 citations

IRRADIATION DECREASES VASCULAR PROSTACYCLIN FORMATION WITH NO CONCOMITANT EFFECT ON PLATELET THROMBOXANE PRODUCTION

1981 • 65 citations

T Cell Potentiation in Normal and Autoimmune-prone Mice after Extended Exposure to Low Doses of Ionizing Radiation and/or Caloric Restriction

1988 • 61 citations

Humoral Control of the Pulmonary Circulation

1980 • 61 citations

The ability of vascular tissue to produce prostacyclin decreases with age

1981 • 57 citations

Acute and Temporary Inhibition of Thymidine Kinase in Mouse Bone Marrow Cells after Low-dose Exposure

1984 • 56 citations

In vitro evaluation of radiation-induced augmentation of the immune response.

1979 • 55 citations

Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.

1978 • 54 citations

The influence of gamma radiation on arachidonic acid release and prostacyclin synthesis

1983 • 47 citations

Radiation-induced augmentation of the response of A/J mice to SaI tumor cells.

1982 • 47 citations

Radiation carcinogenesis from a membrane perspective.

1980 • 45 citations

Interaction between an organic hydroperoxide and an unsaturated phospholipid and α-tocopherol in model membranes

1980 • 45 citations

Evidence for an Adaptive Response to Radiation Damage in Plant Cells Conditioned with X-rays or Incorporated Tritium

1990 • 42 citations

Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide

1978 • 41 citations

Reduced stimulatory activity on prostacyclin production by cultured endothelial cells in serum from aged and diabetic patients

1989 • 41 citations

Radiation induced alterations in rabbit aortic prostacyclin formation

1982 • 38 citations

Stimulation of prostaglandin biosynthesis by lipoic acid

1977 • 37 citations

Radiotherapy and oncology.

1983 • 36 citations

Radioprotection by superoxide dismutase of macrophage progenitor cells from mouse bone marrow

1984 • 32 citations

Tumor-enhancing suppressor activator T cells in spleens and thymuses of tumor immune mice.

1979 • 32 citations

In vivo splenic irradiation eradicates suppressor T-cells causing the regression and inhibition of established tumor

1980 • 26 citations

Long-lasting depression of rabbit aortic prostacyclin formation by single-dose irradiation.

1984 • 26 citations

Long-Lasting Depression of Rabbit Aortic Prostacyclin Formation by Single-Dose Irradiation

1984 • 25 citations

Low dose radiosensitivity of alloimmune cytotoxic T cells.

1982 • 23 citations

Effect of Low-dose Irradiation upon T Cell Subsets Involved in the Response of Primed A/J Mice to SaI Cells

1988 • 22 citations

Ionizing radiation at low doses induces inflammatory reactions in human blood.

1991 • 20 citations

The Effects of Ionizing Radiation on the Pulmonary Endothelial Cell Uptake of α-Aminoisobutyric Acid and Synthesis of Prostacyclin

1986 • 20 citations

Low dose irradiation permits immunization of A/J mice with subimmunogenic numbers of SaI cells

1986 • 16 citations

Ionizing Radiation at Low Doses Induces Inflammatory Reactions in Human Blood

1991 • 16 citations

Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C

1987 • 15 citations

Antitumor effect of whole-body X-irradiation: possible role of an X-ray-sensitive T suppressor cell population.

1979 • 14 citations

[The effect of low-dose total body irradiation on tumor control].

1987 • 13 citations

Identifying Superoxide-sensitive Progenitor Cells in Mouse Bone Marrow

1983 • 10 citations

Effect of radiation on prostaglandin production by human bowel in vitro

1984 • 9 citations

[Anti-tumor effect of total body irradiation of low doses on WHT/Ht mice].

1987 • 8 citations

Studies on Effect of Gamma Radiation on Prostacyclin and Platelet-Activating Factor Synthesis and on Cell Growth Using Smooth Muscle, Fibroblast, and Endothelial Cells in Cultures

1987 • 5 citations

[Augmentation in mitogen-induced proliferation of rat splenocytes by low dose whole body X-irradiation].

1990 • 5 citations

Irradiation of rats abolishes susceptibility of PGI2 synthesis in blood vessels to peroxidative agents

1990 • 4 citations

Radiation, Lipid Peroxidation and the Role of Oxygen Radicals in Eicosanoid Metabolism

1988 • 3 citations

A kallikrein induced new peptide stimulating prostacyclin production by vascular endothelial cells.

1989 • 1 citations

Deleted Work

1955 • 0 citations