Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

Circulating angiogenic factors and the risk of preeclampsia*

2004 • 2,591 citations

Latest Advances in Understanding Preeclampsia

2005 • 2,482 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

2003 • 1,276 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

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2009 • 1,049 citations

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

2004 • 1,037 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy.

1992 • 747 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 • 698 citations

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1995 • 672 citations

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

2002 • 637 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

2005 • 597 citations

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

1996 • 560 citations

Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia

2004 • 499 citations

Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: The Boyd Collection revisited

1999 • 431 citations

Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree

1996 • 420 citations

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

2004 • 417 citations

The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta

2000 • 408 citations

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans

2000 • 397 citations

Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

2003 • 396 citations

Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia

2004 • 392 citations

Molecular Evidence of Placental Hypoxia in Preeclampsia

2005 • 384 citations

Hypoxia-Reoxygenation

2002 • 381 citations

Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

2006 • 377 citations

Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia

2000 • 372 citations

Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies

1999 • 363 citations

Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery doppler waveforms

1996 • 349 citations

Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1

2006 • 332 citations

ARNT-Deficient Mice and Placental Differentiation

1997 • 331 citations

Apoptosis and its role in the trophoblast

2006 • 331 citations

Transforming Growth Factor β1 Induces Hypoxia-inducible Factor-1 Stabilization through Selective Inhibition of PHD2 Expression

2006 • 301 citations

In Vitro Ischemia-Reperfusion Injury in Term Human Placenta as a Model for Oxidative Stress in Pathological Pregnancies

2001 • 278 citations

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

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Hypoxia Up-regulates Prolyl Hydroxylase Activity

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Colocalisation of Vascular Endothelial Growth Factor and Its Flt-1 Receptor in Human Placenta

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Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae

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HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels

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Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

2004 • 205 citations

Adriana and Luisa Castellucci Award Lecture 2001 Hypoxia Inducible Factor-1: Oxygen Regulation of Trophoblast Differentiation in Normal and Pre-eclamptic Pregnancies—A Review

2002 • 202 citations

The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen

2003 • 192 citations

Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1

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Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta

2004 • 172 citations

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Differential Expression of Vascular Endothelial Growth Factor (VEGF), Endocrine Gland Derived-VEGF, and VEGF Receptors in Human Placentas from Normal and Preeclamptic Pregnancies

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Heme oxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO‐2 in preeclampsia and fetal growth restriction

2001 • 118 citations

Dynamic HIF1A Regulation During Human Placental Development1

2006 • 117 citations

Decreased Placental GCM1 (Glial Cells Missing) Gene Expression in Pre-eclampsia

2003 • 114 citations

NO restores HIF-1α hydroxylation during hypoxia: Role of reactive oxygen species

2005 • 111 citations

Human Placental Hypoxia-Inducible Factor-1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in Vivo

2007 • 111 citations

Expression of NADPH Oxidase Isoform 1 (Nox1) in Human Placenta: Involvement in Preeclampsia

2005 • 107 citations

Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.

2003 • 94 citations

Cytokines and Hormones in the Regulation of Hypoxia Inducible Factor-1α (HIF-1α)

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HIF‐1: hypoxia‐inducible factor or dysoxia‐inducible factor?

2006 • 81 citations

Interaction of interstitial trophoblast with placental bed capillaries and venules of normotensive and pre-eclamptic pregnancies

1998 • 76 citations

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

2006 • 56 citations

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

2006 • 56 citations

Hypoxia or hyperoxia in placental insufficiency?

1997 • 56 citations

Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner

2004 • 45 citations

Siah: New Players in the Cellular Response to Hypoxia

2004 • 45 citations

Differential and Reciprocal Regulation between Hypoxia-inducible Factor-α Subunits and their Prolyl Hydroxylases in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

2006 • 19 citations