Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies

Binding of soluble form of fibroblast surface protein, fibronectin, to collagen

1977 • 1,972 citations

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

1986 • 1,618 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

1997 • 959 citations

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

1997 • 920 citations

Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.

1992 • 669 citations

Pre-eclampsia and the placenta

1991 • 592 citations

Integrin switching regulates normal trophoblast invasion

1994 • 580 citations

Oxygen and placental villous development: Origins of fetal hypoxia

1997 • 563 citations

Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.

1993 • 552 citations

Mechanism of control of trophoblast invasion in situ

1991 • 374 citations

Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidencein vivoandin vitro

1991 • 364 citations

Functional Role of Cell Surface Integrins on Human Trophoblast Cell Migration: Regulation by TGF-β, IGF-II, and IGFBP-1

1995 • 358 citations

Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro.

1994 • 306 citations

Invasion of the trophoblasts

1992 • 305 citations

A Simplified In Situ Hybridization Protocol Using Non-radioactively Labeled Probes to Detect Abundant and Rare mRNAs on Tissue Sections

1998 • 305 citations

Human cytotrophoblast invasion is up-regulated by epidermal growth factor: Evidence that paracrine factors modify this process

1994 • 237 citations

Activin Is a Local Regulator of Human Cytotrophoblast Cell Differentiation¹

1997 • 225 citations

Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast

1995 • 211 citations

Endoglin Regulates Trophoblast Differentiation along the Invasive Pathway in Human Placental Villous Explants*

1997 • 199 citations

Villous culture of first trimester human placenta-model to study extravillous trophoblast (EVT) differentiation

1992 • 198 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

TNFα concentrations and mRNA expression are increased in preeclamptic placentas

1996 • 191 citations

Altered Expression of Human Leukocyte Antigen G (HLA‐G) on Extravillous Trophoblasts in Preeclampsia: Immunohistological Demonstration With Anti‐HLA‐G Specific Antibody “87G” and Anti‐cytokeratin Antibody “CAM5.2”

1996 • 176 citations

VEGF mRNA levels in placentae from pregnancies complicated by pre‐eclampsia

1996 • 152 citations

Hypertensive Disorders of Pregnancy

2016 • 150 citations

Diagnosis of preeclampsia.

1985 • 147 citations

Transforming Growth Factor β1 Inhibits Placental Differentiation and Human Chorionic Gonadotropin and Human Placental Lactogen Secretion

1991 • 134 citations

Insulin-like growth factor binding protein-1 at the maternal-fetal interface and insulin-like growth factor-I, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia

1997 • 133 citations

Reduced Expression of Transforming Growth Factor β Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells

1996 • 122 citations

Localization of Endoglin, a Transforming Growth Factor-β Binding Protein, and of CD44 and Integrins in Placenta during the First Trimester of Pregnancy1

1994 • 121 citations

Biochemical evidence of impaired trophoblastic invasion of decidual stroma in women destined to have preeclampsia

1996 • 111 citations

Specific Transforming Growth Factor-β Subtypes Regulate Embryonic Mouse Meckel's Cartilage and Tooth Development

1994 • 106 citations

Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients

1996 • 82 citations

Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles.

1993 • 76 citations

Integrins and adhesion molecules: Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts*

1995 • 73 citations

Cloning and Expression of Glucocorticoid-induced Genes in Fetal Rat Lung Fibroblasts

1995 • 71 citations

Localization of alpha 2, alpha 5 and alpha 6 integrin subunits in human endometrium, decidua and trophoblast

1993 • 59 citations

Pre-eclampsia — the ‘disease of theories’

1994 • 57 citations

The function of elevated plasma fibronectin in preeclampsia

1992 • 51 citations

Trophoblast function in normal and preeclamptic pregnancy

1996 • 36 citations

High blood levels of macrophage colony-stimulating factor in preeclampsia

1996 • 33 citations

New developments in pre-eclampsia

1990 • 33 citations

Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia

1995 • 21 citations

Loss of responsiveness to transforming growth factor β (TGFβ) is tightly linked to tumorigenicity in a model of thyroid tumour progression

1996 • 21 citations

Eclampsia in association with partial molar pregnancy and congenital abnormalities

1993 • 18 citations

Role of Locally Produced Growth Factors in Human Placental Growth and Invasion with Special Reference to Transforming Growth Factors

1994 • 16 citations

Uses of antisense nucleic acids — an introduction

1992 • 11 citations