NO restores HIF-1α hydroxylation during hypoxia: Role of reactive oxygen species

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Oxygen sensing by HIF hydroxylases

2004 • 1,946 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

1998 • 1,566 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

2004 • 889 citations

Methods in nitric oxide research

1996 • 826 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Methods in Nitric Oxide Research

1997 • 726 citations

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 • 698 citations

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

2003 • 683 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

2004 • 560 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing

2003 • 428 citations

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

2003 • 390 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide

2004 • 278 citations

A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α

2001 • 265 citations

Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways

2003 • 257 citations

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

1999 • 241 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

2001 • 197 citations

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase

2004 • 182 citations

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

2004 • 168 citations

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

2003 • 168 citations

The oxidation of tiron by superoxide anion. Kinetics of the reaction in aqueous solution and in chloroplasts

1975 • 153 citations

How oxygen makes its presence felt: Figure 1.

2002 • 149 citations

Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway

2001 • 143 citations

Role of nitric oxide in the regulation of HIF-1α expression during hypoxia

2002 • 136 citations

Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

2001 • 126 citations

Superoxide as an Intermediate Signal for Serotonin-Induced Mitogenesis 11This study was supported by Research Grant HL 32723 from the Heart, Lung, and Blood Institute of the National Institutes of Health.

1998 • 113 citations

The Role of Nitric Oxide (NO) in Stability Regulation of Hypoxia Inducible Factor-1α (HIF-1α)

2003 • 107 citations

Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

2001 • 103 citations

Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase

2004 • 79 citations

Redox regulation of HIF-1α levels and HO-1 expression in renal medullary interstitial cells

2003 • 79 citations

Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia inducible factor‐1α (HIF‐ 1α) in explants of human pial arteries

2003 • 72 citations

Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1

2003 • 65 citations

Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression

2000 • 62 citations

Binding and regulation of HIF‐1α by a subunit of the proteasome complex, PSMA7

2001 • 61 citations

The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species

2004 • 58 citations

Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing

2000 • 40 citations

Pulse-radiolytic investigations of catechols and catecholamines II. Reactions of Tiron with oxygen radical species

1979 • 35 citations

Reactive Oxygen Species as Regulators of Oxygen Dependent Gene Expression

2002 • 34 citations

The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway

2004 • 29 citations