Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

2003 • 1,276 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Molecular basis of the VHL hereditary cancer syndrome

2002 • 826 citations

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

2003 • 771 citations

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

2001 • 748 citations

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 • 698 citations

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

2001 • 688 citations

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 • 633 citations

Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing

2003 • 428 citations

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor

2003 • 424 citations

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

2004 • 417 citations

Hypoxia-inducible Factor and Its Biomedical Relevance

2003 • 307 citations

Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3

2002 • 299 citations

A novel quasi-viral agent, MaTu, is a two-component system

1992 • 283 citations

Hypoxia Up-regulates Prolyl Hydroxylase Activity

2003 • 274 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

1999 • 241 citations

Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar

2002 • 236 citations

Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

2004 • 205 citations

MammalianEGLNgenes have distinct patterns of mRNA expression and regulation

2002 • 188 citations

Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

2003 • 165 citations

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

2002 • 165 citations

Characterization and comparative analysis of the EGLN gene family

2001 • 143 citations

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

2002 • 116 citations

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

2002 • 108 citations

Identification of a novel growth factor-responsive gene in vascular smooth muscle cells.

1994 • 83 citations

Mapping, Characterization, and Expression Analysis of the SM-20 Human Homologue, C1orf12, and Identification of a Novel Related Gene, SCAND2

2000 • 38 citations

Falkor, a novel cell growth regulator isolated by a functional genetic screen

2002 • 19 citations