Identification of Critical Amino Acid Residues in Human Immunodeficiency Virus Type 1 IN Required for Efficient Proviral DNA Formation at Steps prior to Integration in Dividing and Nondividing Cells

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.

1986 • 1,242 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Crystal Structure of the Catalytic Domain of HIV-1 Integrase: Similarity to Other Polynucleotidyl Transferases

1994 • 804 citations

Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases.

1992 • 555 citations

Binding and Stimulation of HIV-1 Integrase by a Human Homolog of Yeast Transcription Factor SNF5

1994 • 523 citations

Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

1992 • 517 citations

THE RETROVIRAL ENZYMES

1994 • 517 citations

Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.

1994 • 496 citations

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1997 • 483 citations

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

1986 • 483 citations

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.

1993 • 449 citations

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

1995 • 428 citations

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

1994 • 381 citations

Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus

1992 • 376 citations

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase

1995 • 360 citations

HIV-1 cDNA Integration: Requirement of HMG I(Y) Protein for Function of Preintegration Complexes In Vitro

1997 • 358 citations

Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.

1993 • 352 citations

Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.

1993 • 347 citations

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import

1997 • 340 citations

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

1996 • 333 citations

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity.

1990 • 329 citations

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

1997 • 329 citations

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex

1998 • 320 citations

Solution Structure of the DNA Binding Domain of HIV-1 Integrase

1995 • 291 citations

Retroviral integrase domains: DNA binding and the recognition of LTR sequences

1991 • 289 citations

Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1993 • 275 citations

Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

1998 • 271 citations

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells

1995 • 264 citations

Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells

1992 • 261 citations

A Role for DNA-PK in Retroviral DNA Integration

1999 • 255 citations

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression

1994 • 253 citations

Residues Critical for Retroviral Integrative Recombination in a Region That Is Highly Conserved among Retroviral/Retrotransposon Integrases and Bacterial Insertion Sequence Transposases

1992 • 244 citations

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 Isolate

1994 • 237 citations

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

1996 • 235 citations

The DNA-binding domain of HIV-1 integrase has an SH3-like fold

1995 • 233 citations

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection

1996 • 232 citations

Complementation between HIV integrase proteins mutated in different domains.

1993 • 231 citations

GENETICS OF RETROVIRAL INTEGRATION

1992 • 224 citations

Retroviral Reverse Transcription and Integration: Progress and Problems

1992 • 216 citations

The terminal nucleotides of retrovirus DNA are required for integration but not virus production

1983 • 193 citations

The barrier-to-autointegration protein is a host factor for HIV type 1 integration

1998 • 188 citations

Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex

1998 • 185 citations

Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations

1993 • 184 citations

Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population

1995 • 177 citations

Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage

1991 • 176 citations

Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.

1992 • 169 citations

Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences

1997 • 168 citations

Substrate specificity of recombinant human immunodeficiency virus integrase protein

1991 • 158 citations

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase

1998 • 156 citations

Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain

1995 • 154 citations

Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

1996 • 154 citations

A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract

1991 • 148 citations

An Essential Interaction between Distinct Domains of HIV-1 Integrase Mediates Assembly of the Active Multimer

1995 • 130 citations

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.

1996 • 121 citations

Genetic analysis of the human immunodeficiency virus type 1 integrase protein

1994 • 120 citations

HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro

1999 • 118 citations

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues

1994 • 105 citations

Irreversible Inhibition of Human Immunodeficiency Virus Type 1 Integrase by Dicaffeoylquinic Acids

1999 • 93 citations

Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro

1995 • 91 citations

Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription

1989 • 85 citations

A mutation at one end of Moloney murine leukemia virus DNA blocks cleavage of both ends by the viral integrase in vivo

1992 • 84 citations

Sequence requirements for integration of Moloney murine leukemia virus DNA in vitro

1990 • 81 citations

HIV-1 nuclear import in search of a leader

1997 • 78 citations

Specific and Independent Recognition of U3 and U5 att Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo

1998 • 76 citations

Relationship of avian retrovirus DNA synthesis to integration in vitro.

1991 • 72 citations

Phosphorylation of Residue 131 of HIV-1 Matrix Is Not Required for Macrophage Infection

1997 • 71 citations

Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates

1994 • 63 citations

A new reporter system for detection of retroviral infection.

1995 • 54 citations

Lack of Infectivity of HIV-1 Integrase Zinc Finger-like Domain Mutant with Morphologically Normal Maturation

1997 • 48 citations

Characterization of (+) Strand Initiation and Termination Sequences Located at the Center of the Equine Infectious Anemia Virus Genome

1999 • 42 citations

Relationship of Avian Retrovirus DNA Synthesis to Integration In Vitro

1991 • 40 citations

Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity

1996 • 29 citations

Isolation and Characterization of an Oligomerization-Negative Mutant of HIV-1 Integrase

1999 • 28 citations

Influence of subterminal viral DNA nucleotides on differential susceptibility to cleavage by human immunodeficiency virus type 1 and visna virus integrases

1996 • 21 citations

Avian retrovirus pp32 DNA endonuclease is phosphorylated on Ser in the carboxyl-terminal region

1988 • 15 citations