Infectious Entry by Amphotropic as well as Ecotropic Murine Leukemia Viruses Occurs through an Endocytic Pathway

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Lysosomotropic agents

1974 • 1,887 citations

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

1988 • 1,737 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

A spring-loaded mechanism for the conformational change of influenza hemagglutinin

1993 • 854 citations

On the entry of semliki forest virus into BHK-21 cells

1980 • 808 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

Membrane fusion proteins of enveloped animal viruses

1983 • 670 citations

Virus Entry into Animal Cells

1989 • 625 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses.

1981 • 569 citations

Vacuolar ATPase activity is required for endosomal carrier vesicle formation.

1994 • 418 citations

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

1993 • 415 citations

Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A

1997 • 353 citations

Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus

1992 • 337 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

Effect of Bafilomycin A1 and Nocodazole on Endocytic Transport in HeLa Cells: Implications for Viral Uncoating and Infection

1998 • 325 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Retroviral Entry Mediated by Receptor Priming and Low pH Triggering of an Envelope Glycoprotein

2000 • 280 citations

A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina.

1992 • 261 citations

Inhibition of Semliki Forest Virus Penetration by Lysosomotropic Weak Bases

1982 • 248 citations

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

1991 • 228 citations

The pH independence of mammalian retrovirus infection

1990 • 210 citations

Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.

1993 • 205 citations

pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: implications for the role of the R peptide and p12E TM in viral entry

1994 • 189 citations

Characterization of Intracellular Reverse Transcription Complexes of Moloney Murine Leukemia Virus

1999 • 138 citations

Entry of poliovirus into cells does not require a low-pH step

1993 • 117 citations

Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells

1995 • 117 citations

Retrograde Transport from the Pre-Golgi Intermediate Compartment and the Golgi Complex Is Affected by the Vacuolar H⁺-ATPase Inhibitor Bafilomycin A1

1998 • 105 citations

Inhibition of the vacuolar H(+)-ATPase with bafilomycin reduces delivery of internalized molecules from mature multivesicular endosomes to lysosomes in HEp-2 cells.

1996 • 102 citations

Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours

1997 • 101 citations

Requirements for different components of the host cell cytoskeleton distinguish ecotropic murine leukemia virus entry via endocytosis from entry via surface fusion

1997 • 99 citations

Entry of murine retrovirus into mouse fibroblasts

1983 • 92 citations

Survival of HIV‐1 activity after disinfection, temperature and pH changes, or drying

1991 • 91 citations

Increased Viral Titer Through Concentration of Viral Harvests from Retroviral Packaging Lines

1993 • 86 citations

Mouse mammary tumor virus can mediate cell fusion at reduced pH

1984 • 75 citations

Inhibitors of vacuolar‐type H⁺‐ATPase suppresses proliferation of cultured cells

1993 • 74 citations

Function of Human Cytomegalovirus Glycoprotein B: Syncytium Formation in Cells Constitutively Expressing gB Is Blocked by Virus-Neutralizing Antibodies

1994 • 71 citations

Sequences determining the pH dependence of viral entry are distinct from the host range-determining region of the murine ecotropic and amphotropic retrovirus envelope proteins

1993 • 56 citations

Microtubules are involved in bafilomycin A1-induced tubulation and Rab5-dependent vacuolation of early endosomes.

1997 • 53 citations

Differentiation of acid-ph-dependent and -nondependent entry pathways for mouse hepatitis virus

1991 • 52 citations

Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H+-ATPase

1993 • 49 citations

A Dissection of Steps Leading to Viral Envelope Protein‐Mediated Membrane Fusion

1991 • 47 citations

Coupled Effects of Polybrene and Calf Serum on the Efficiency of Retroviral Transduction and the Stability of Retroviral Vectors

1997 • 44 citations

Bafilomycin A₁ induces apoptosis in PC12 cells independently of intracellular pH

1996 • 33 citations

Quantitative determination of virus‐membrane fusion events Fusion of influenza virions with plasma membranes and membranes of endocytic vesicles in living cultured cells

1987 • 30 citations

Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts

1996 • 28 citations

Evidence for endocytosis-independent infection by human rotavirus

1987 • 27 citations

The HPV-16 E5 oncogene and bafilomycin A1 influence cell motility

1999 • 20 citations