Differential regulation of microglial activation by propentofylline via cAMP signaling

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Tumor Necrosis Factor-α

1997 • 864 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Ameboid microglia as effectors of inflammation in the central nervous system

1987 • 477 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures

1994 • 243 citations

Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival.

1994 • 193 citations

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1

1995 • 166 citations

Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat.

1992 • 151 citations

Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils

1996 • 113 citations

Modulation of Intracellular Formation of Reactive Oxygen Intermediates in Peritoneal Macrophages and Microglia/Brain Macrophages by Propentofylline

1994 • 107 citations

Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation

1994 • 101 citations

Hypothermic suppression of microglial activation in culture: inhibition of cell proliferation and production of nitric oxide and superoxide

1997 • 94 citations

Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells

1990 • 89 citations

Adenosine and Propentofylline Inhibit the Proliferation of Cultured Microglial Cells

1996 • 83 citations

Propentofylline: A nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia

1994 • 78 citations

Two distinct inwardly rectifying conductances are expressed in long term dibutyryl‐cyclic‐AMP treated rat cultured cortical astrocytes

1995 • 73 citations

Glia: The not so innocent bystanders

1996 • 64 citations

Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic Approach by Propentofylline^a

1997 • 52 citations

Modulation of neuronal and glial cell function by adenosine and neuroprotection in vascular demential

1997 • 46 citations

Albumin enhances superoxide production in cultured microglia

1997 • 41 citations

In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity.

1985 • 31 citations

Adenosine inhibits superoxide production in rat peritoneal macrophages via elevation of cAMP level

1997 • 27 citations

Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum

1997 • 20 citations

Modulation of glial cell signaling by adenosine and pharmacological reinforcement

1996 • 14 citations

Modulation of cytokine expression by cAMP analogs in myc-immortalized microglial cell lines.

1993 • 9 citations