Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

Gender variations in clinical pain experience

1996 • 1,525 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1999 • 830 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states

1995 • 656 citations

Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1995 • 573 citations

Kappa–opioids produce significantly greater analgesia in women than in men

1996 • 461 citations

Endoneurial injection of TNF-α produces neuropathic pain behaviors

1996 • 421 citations

Interleukin-6-Mediated Hyperalgesia/Allodynia and Increased Spinal IL-6 Expression in a Rat Mononeuropathy Model

1996 • 366 citations

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat

1997 • 345 citations

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

1994 • 340 citations

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat

1997 • 338 citations

Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat

1999 • 320 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Cytokines and the nervous system I: expression and recognition

1995 • 307 citations

Hyperalgesia in Experimental Neuropathy Is Dependent on the TNF Receptor 1

1998 • 299 citations

Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-α expression

1998 • 250 citations

Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy

1997 • 247 citations

Gender difference in analgesic response to the kappa-opioid pentazocine

1996 • 237 citations

Mechanisms of tumor necrosis factor-α (TNF-α) hyperalgesia

1995 • 222 citations

Endogenous interleukin‐6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice

1999 • 207 citations

Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice

1994 • 199 citations

Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy

1999 • 186 citations

Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice

1998 • 172 citations

Astrocytes as mediators of immune and inflammatory responses in the CNS.

1998 • 169 citations

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain

1998 • 151 citations

Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats

1993 • 142 citations

Prolonged ovarian sex steroid treatment of male rats produces antinociception: identification of sex-based divergent analgesic mechanisms

2000 • 130 citations

Cascading Glia Reactions: a Common Pathomechanism and Its Differentiated Control by Cyclic Nucleotide Signaling

2000 • 129 citations

Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats

1995 • 127 citations

Interleukin-1β induces long-term increase of axonally transported opiate receptors and substance P

1995 • 118 citations

Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists

1999 • 111 citations

Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model

2000 • 92 citations

PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases

1999 • 90 citations

Gender differences in rat neuropathic pain sensitivity is dependent on strain

2000 • 83 citations

Possible Involvement of Interleukin‐1 in Cyclooxygenase‐2Induction After Spinal Cord Injury in Rats

1999 • 74 citations

Tumor necrosis factor‐α induces substance P in sympathetic ganglia through sequential induction of interleukin‐1 and leukemia inhibitory factor

1995 • 57 citations

Tumour necrosis factor-α increases intracellular Ca²⁺ and induces a depolarization in cultured astroglial cells

1996 • 53 citations

Intracerebroventricular Injection of Tumor Necrosis Factor-αInduces Thermal Hyperalgesia in Rats

1996 • 50 citations

Biphasic effects of intracerebroventricular interleukin-1 β on mechanical nociception in the rat

1996 • 42 citations

Spinal interleukin-1 β reduces inflammatory pain

2000 • 36 citations

Kidney as a Major Clearance Organ for Recombinant Human Interleukin‐1 Receptor Antagonist

1995 • 30 citations

Involvement of corticotropin-releasing factor in the antinociception produced by interleukin-1 in mice

1993 • 29 citations

Effects of interleukin-1 receptor antagonist in a slow-release hylan vehicle on rat type II collagen arthritis.

1998 • 28 citations

Microtiter Immunocytochemical ELISA Assay

1999 • 22 citations

Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene.

1997 • 16 citations