Proinflammatory cytokines and glial cells: Their role in neuropathic pain

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Advances in Pain Research and Therapy

1980 • 2,255 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

THE MANAGEMENT OF PAIN

1954 • 1,496 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Nitric oxide (NO) and nociceptive processing in the spinal cord

1993 • 958 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

1993 • 730 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Advances in pain research and therapy

2007 • 653 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

Nerve growth factor and nociception

1993 • 530 citations

Characterization of cytokine-induced hyperalgesia

1994 • 506 citations

Peripheral and Central Mechanisms of NGF‐induced Hyperalgesia

1994 • 505 citations

Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response

1990 • 483 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

Endoneurial injection of TNF-α produces neuropathic pain behaviors

1996 • 421 citations

Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury

1991 • 396 citations

The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

1994 • 368 citations

Interleukin-6-Mediated Hyperalgesia/Allodynia and Increased Spinal IL-6 Expression in a Rat Mononeuropathy Model

1996 • 366 citations

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat

1997 • 345 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

1994 • 340 citations

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat

1997 • 338 citations

News on glutamate receptors in glial cells

1996 • 337 citations

Functions and mechanisms of interleukin 1 in the brain

1991 • 325 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain.

1996 • 311 citations

Neuronal differentiation factors/cytokines and synaptic plasticity

1993 • 289 citations

MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy

1991 • 276 citations

Induction of interleukin-6 in axotomized sensory neurons

1995 • 273 citations

Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury

1995 • 254 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy

1997 • 247 citations

Cytokines in anaesthesia

1997 • 239 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Interleukin‐6 and Transforming Growth Factor‐β1 mRNAs are Induced in Rat Facial Nucleus Following Motoneuron Axotomy

1993 • 205 citations

Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus

1988 • 200 citations

Hyperalgesia and allodynia

1992 • 186 citations

Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine

1993 • 181 citations

The Immune Logical Brain

1987 • 175 citations

The Brain's Immune System

1995 • 170 citations

IL‐6 Expression in Neurons of Transgenic Mice Causes Reactive Astrocytosis and Increase in Ramified Microglial Cells but no Neuronal Damage

1995 • 162 citations

Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat

1981 • 160 citations

Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat

1994 • 154 citations

Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats

1993 • 142 citations

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

1994 • 141 citations

Voltage-gated Na+ channels in glia: properties and possible functions

1996 • 132 citations

Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1

1995 • 129 citations

Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats

1995 • 127 citations

gp130, a Shared Signal Transducing Receptor Component for Hematopoietic and Neuropoietic Cytokines

1996 • 126 citations

Interleukin-1 activity in lesioned peripheral nerve

1992 • 114 citations

Regulation of nerve growth factor synthesis/secretion by catecholamine in cultured mouse astroglial cells

1987 • 110 citations

Low back pain : a scientific and clinical overview

1996 • 105 citations

Axonal blockade induces the expression of vasoactive intestinal polypeptide and galanin in rat dorsal root ganglion neurons

1992 • 102 citations

Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons

1995 • 94 citations

Tumor necrosis factor receptors in HeLa cells and their regulation by interferon-gamma.

1986 • 86 citations

Intracerebroventricular injection of interleukin-1β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats

1994 • 77 citations

Norepinephrine inhibits gamma-interferon-induced MHC class II (Ia) antigen expression on cultured brain astrocytes

1988 • 71 citations

Spinal dynorphin immunoreactivity increases bilaterally in a neuropathic pain model

1993 • 58 citations

Tumor necrosis factor‐α induces substance P in sympathetic ganglia through sequential induction of interleukin‐1 and leukemia inhibitory factor

1995 • 57 citations

Tumour necrosis factor-α increases intracellular Ca²⁺ and induces a depolarization in cultured astroglial cells

1996 • 53 citations

The opposing effects of interleukin-1 β microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats

1995 • 50 citations

Differential behavioral outcomes in the sciatic cryoneurolysis model of neuropathic pain in rats

1994 • 40 citations

Localization of beta-adrenergic receptors on differentiated cells of the central nervous system in culture.

1987 • 33 citations

Somatic afferent fibers which continuously discharge after being isolated from their receptors

1992 • 32 citations

Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation

1990 • 30 citations

Autotomy and decreased spinal substance P following peripheral cryogenic nerve lesion

1991 • 18 citations

Interleukin-1 β facilitates afferent sensory transmission in the primary somatosensory cortex of anesthetized rats

1995 • 6 citations