Time after time: inputs to and outputs from the mammalian circadian oscillators

Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

2002 • 3,319 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity

2002 • 2,510 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

Extensive and divergent circadian gene expression in liver and heart

2002 • 1,498 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

A Novel Human Opsin in the Inner Retina

2000 • 1,236 citations

Time zones: a comparative genetics of circadian clocks

2001 • 1,142 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

Circadian rhythms from flies to human

2002 • 979 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

2002 • 785 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

2002 • 701 citations

Circadian Rhythms in Isolated Brain Regions

2002 • 648 citations

A neural circuit for circadian regulation of arousal

2001 • 600 citations

Hypothalamic integration of central and peripheral clocks

2001 • 557 citations

Melanopsin in cells of origin of the retinohypothalamic tract

2001 • 556 citations

NPAS2: An Analog of Clock Operative in the Mammalian Forebrain

2001 • 555 citations

The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei

2002 • 541 citations

Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

2001 • 533 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators

2001 • 467 citations

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

2001 • 465 citations

Photoreceptive net in the mammalian retina

2002 • 458 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

Molecular Bases of Circadian Rhythms

2001 • 420 citations

Drosophila CRY Is a Deep Brain Circadian Photoreceptor

2000 • 400 citations

CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications

1997 • 393 citations

mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

2001 • 376 citations

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism

2001 • 374 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract

2002 • 332 citations

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

2002 • 328 citations

Stopping Time: The Genetics of Fly and Mouse Circadian Clocks

2001 • 310 citations

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

2000 • 293 citations

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

2000 • 291 citations

Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei

2000 • 281 citations

Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock

2002 • 263 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene

2001 • 251 citations

Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock

2002 • 241 citations

Role of DBP in the Circadian Oscillatory Mechanism

2000 • 235 citations

Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker

2001 • 225 citations

Multilevel regulation of the circadian clock

2000 • 219 citations

NEW EMBO MEMBERS' REVIEW: The black cat/white cat principle of signal integration in bacterial promoters

2001 • 210 citations

Molecular Components of the Circadian System in Drosophila

2001 • 210 citations

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

2002 • 179 citations

Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

2002 • 157 citations

Dissociation between Light-Induced Phase Shift of the Circadian Rhythm and Clock Gene Expression in Mice Lacking the Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor

2001 • 155 citations

Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2

2002 • 149 citations

The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity

2000 • 149 citations

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

2001 • 144 citations

Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues

2000 • 143 citations

Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C

2001 • 137 citations

Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε

2000 • 135 citations

Light Induction of a Vertebrate Clock Gene Involves Signaling through Blue-Light Receptors and MAP Kinases

2002 • 133 citations

Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts

2001 • 131 citations

Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs

2001 • 122 citations

Oscillating on Borrowed Time: Diffusible Signals from Immortalized Suprachiasmatic Nucleus Cells Regulate Circadian Rhythmicity in Cultured Fibroblasts

2001 • 104 citations

Redox Potential

2002 • 101 citations

Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4 , a potential transcriptional repressor of cPer2 gene

2001 • 96 citations

Vasoactive intestinal polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night

2002 • 89 citations

Circadian Changes in Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Distribution Inside Individual Chloroplasts Can Account for the Rhythm in Dinoflagellate Carbon Fixation

2001 • 85 citations

Pituitary adenylate cyclase-activating polypeptide induces period1 and period2 gene expression in the rat suprachiasmatic nucleus during late night

2001 • 78 citations

Expression of the Per1 gene in the hamster: brain atlas and circadian characteristics in the suprachiasmatic nucleus.

2001 • 71 citations

Light and Glutamate-Induced Degradation of the Circadian Oscillating Protein BMAL1 during the Mammalian Clock Resetting

2000 • 70 citations

Expression of thePer1 gene in the hamster: Brain atlas and circadian characteristics in the suprachiasmatic nucleus

2001 • 65 citations

Visualization of mPer1 transcription in vitro

2001 • 65 citations

Cloning and characterization of rat casein kinase 1ϵ

2000 • 62 citations

Signaling to the Mammalian Circadian Clocks: In Pursuit of the Primary Mammalian Circadian Photoreceptor

2001 • 46 citations

Rev‐erbα gene expression in the mouse brain with special emphasis on its circadian profiles in the suprachiasmatic nucleus

2002 • 40 citations

A novel protein interacts with a clock-related protein, rPer1

2001 • 16 citations