Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

The S100 family of EF-hand calcium-binding proteins: functions and pathology

1996 • 1,002 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

DNA methylation and cancer

1994 • 418 citations

Positive selection of candidate tumor-suppressor genes by subtractive hybridization.

1991 • 320 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

1995 • 301 citations

Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1.

1993 • 253 citations

Expression pattern of S100 calcium-binding proteins in human tumors

1996 • 224 citations

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1995 • 220 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

DNA methylation: Molecular biology and biological significance

1993 • 193 citations

Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.

1995 • 184 citations

Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours.

1996 • 182 citations

Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

1993 • 181 citations

Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene.

1996 • 169 citations

Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure.

1996 • 165 citations

Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.

1992 • 161 citations

Expression of Ca²⁺‐binding proteins of the S100 family in malignant human breast‐cancer cell lines and biopsy samples

1994 • 134 citations

Regulated Demethylation of themyoDDistal Enhancer during Skeletal Myogenesis

1996 • 96 citations

Isolation of a new member of the S100 protein family: amino acid sequence, tissue, and subcellular distribution.

1989 • 95 citations

The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours

1990 • 80 citations

Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the 5100 gene cluster on chromosome 1q21

1996 • 76 citations

Characterization of the Human and Mouse cDNAsCoding for S100A13, a New Member of the S100 Protein Family

1996 • 72 citations

Induction of18A2/mts1Gene Expression and Its Effects on Metastasis and Cell Cycle Control

1994 • 48 citations

Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation

1995 • 42 citations

Novel AP-1 binding site created by DNA-methylation.

1996 • 28 citations