Biology of the Osteoclast

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Carbonic anhydrase: chemistry, physiology, and inhibition

1967 • 1,882 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

1988 • 1,737 citations

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

1990 • 1,028 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

1989 • 864 citations

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

1990 • 827 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Osteoclast-Like Cell Formation and its Regulation by Osteotropic Hormones in Mouse Bone Marrow Cultures*

1988 • 745 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification.

1983 • 609 citations

Structure and function of vacuolar class of ATP-driven proton pumps

1989 • 600 citations

Calcitonin alters behaviour of isolated osteoclasts

1982 • 509 citations

Cells of bone: proliferation, differentiation, and hormonal regulation

1986 • 479 citations

1α,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells

1981 • 460 citations

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

1986 • 456 citations

Trafficking of lysosomal enzymes in normal and disease states.

1986 • 445 citations

MACROPHAGE COLONY STIMULATING FACTOR RESTORESIN VIVOBONE RESORPTION IN THEOP/OPOSTEOPETROTIC MOUSE

1990 • 441 citations

The Effect of Calcium-Regulating Hormones and Prostaglandins on Bone Resorption by Osteoclasts Disaggregated from Neonatal Rabbit Bones*

1985 • 419 citations

Avian osteoclasts as estrogen target cells.

1991 • 394 citations

Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts.

1990 • 390 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor.

1989 • 372 citations

Glutamate uptake by brain synaptic vesicles. Energy dependence of transport and functional reconstitution in proteoliposomes.

1988 • 357 citations

Effect of pH on Bone Resorption by Rat Osteoclastsin Vitro

1986 • 339 citations

Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts.

1988 • 332 citations

ON THE MECHANISMS OF BONE RESORPTION

1968 • 331 citations

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures.

1984 • 324 citations

The evolution of H+-ATPases

1989 • 313 citations

Biology and Physiology of the Osteoclast

1992 • 297 citations

The mannose-6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae

1984 • 291 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow.

1985 • 280 citations

Isolated osteoclasts resorb the organic and inorganic components of bone.

1986 • 276 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

CARTILAGE RESORPTION IN THE TIBIAL EPIPHYSEAL PLATE OF GROWING RATS

1967 • 266 citations

Molecular mechanisms of bone resorption by the osteoclast

1989 • 262 citations

Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase.

1987 • 256 citations

Proton-Translocating ATPases

1986 • 255 citations

The Ultrastructure of the Osteoclast and its Functional Implications

1977 • 247 citations

Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro

1991 • 245 citations

Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts

1989 • 227 citations

Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption.

1990 • 225 citations

Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions*1

1987 • 216 citations

Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells.

1984 • 212 citations

Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat.

1980 • 210 citations

Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway.

1988 • 209 citations

Echistatin is a potent inhibitor of bone resorption in culture.

1990 • 201 citations

Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells

1989 • 199 citations

The Sensitivity of Isolated Osteoclasts to Morphological Transformation by Calcitonin*

1983 • 198 citations

Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption

1990 • 178 citations

Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure.

1988 • 174 citations

Organization of osteoclast microfilaments during the attachment to bone surface in vitro

1989 • 173 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

Omeprazole, a specific inhibitor of H+−K+-ATPase, inhibits bone resorptionin vitro

1986 • 165 citations

A band of F-actin containing podosomes is involved in bone resorption by osteoclasts

1990 • 155 citations

Osteoclastic bone resorption: In vitro analysis of the rate of resorption and migration of individual osteoclasts

1988 • 155 citations

Acidification of endosome subpopulations in wild-type Chinese hamster ovary cells and temperature-sensitive acidification-defective mutants.

1989 • 153 citations

Sensitivity to vanadate and isoforms of subunits A and B distinguish the osteoclast proton pump from other vacuolar H+ ATPases.

1992 • 152 citations

Carbonic Anhydrase and Osteoclasts: Localization by Labeled Inhibitor Autoradiography

1974 • 147 citations

Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures.

1989 • 145 citations

Cellular Differences in Acid Phosphatase Isoenzymes in Bone and Teeth

1971 • 144 citations

Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity

1991 • 142 citations

Carbonic Anhydrase and Bone Remodeling: Sulfonamide Inhibition of Bone Resorption in Organ Culture

1972 • 138 citations

Perspectives: Adhesion receptors in bone

1989 • 136 citations

Structure and pharmacology of the proton-ATPases

1991 • 135 citations

The distribution of podosomes in osteoclasts cultured on bone laminae: Effect of retinol

1988 • 135 citations

Acid phosphatase of osteoclasts demonstrated by electron microscopic histochemistry

1971 • 134 citations

Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.

1989 • 132 citations

Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase

1991 • 127 citations

Actin-like filaments in bone cells of cultured mouse calvaria as demonstrated by binding to heavy meromyosin.

1975 • 127 citations

Acidification and Ion Permeabilities of Highly Purified Rat Liver Endosomes

1989 • 123 citations

Monoclonal antibodies against osteoclasts inhibit bone resorption in vitro.

1986 • 122 citations

Isolated osteoclasts in primary culture: first observations on structure and survival in culture media

1982 • 121 citations

Electron microscopic localization of hydrolytic enzymes in osteoclasts

1972 • 119 citations

Oxygen derived free radicals in osteoclasts: The specificity and location of the nitroblue tetrazolium reaction

1990 • 118 citations

Identification of osteoclast-specific monoclonal antibodies.

1985 • 112 citations

Effect of parathyroid hormone and calcitonin on the cytoplasmic spreading of isolated osteoclasts

1984 • 111 citations

Cloning, sequence, and developmental expression of a type 5, tartrate-resistant, acid phosphatase of rat bone.

1991 • 109 citations

Passive chloride permeability charge coupled to H(+)-ATPase of avian osteoclast ruffled membrane

1991 • 109 citations

Isolated osteoclasts and their presumed progenitor cells, the monocyte, in culture

1982 • 108 citations

No 1,25-dihydroxyvitamin D3 receptors on osteoclasts of calcium-deficient chicken despite demonstrable receptors on circulating monocytes.

1986 • 105 citations

Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast

1986 • 104 citations

Characterization of the latent transforming growth factor ß complex in Bone

1990 • 103 citations

Effect of vitamin a on bone resorption: Evidence for direct stimulation of isolated chicken osteoclasts by retinol and retinoic acid

1988 • 100 citations

Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase.

1990 • 94 citations

Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass

1988 • 87 citations

Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles

1990 • 83 citations

Generation of osteoclasts in vitro

1981 • 83 citations

Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures.

1989 • 77 citations

Biological activity of chicken calcitonin: Effects on neonatal rat and embryonic chick osteoclasts

1987 • 75 citations

Selective internalization of the apical plasma membrane and rapid redistribution of lysosomal enzymes and mannose 6-phosphate receptors during osteoclast inactivation by calcitonin

1990 • 74 citations

Hormonal regulation of acid phosphatase release by osteoclasts disaggregated from neonatal rat bone

1987 • 73 citations

Humoral and ionic regulation of osteoclast acidity

1986 • 73 citations

Ultrastructural localization of a tartrate-resistant acid ATPase in bone

1990 • 72 citations

Inhibition of Bone Resorption by Acetazolamide in the Rat¹

1970 • 72 citations

Bone resorption by isolated human osteoclasts in vitro: Effects of calcitonin

1989 • 71 citations

Inwardly rectifying K+ current in osteoclasts

1989 • 70 citations

Evidence of coated membranes in the ruffled border of the osteoclast

1971 • 63 citations

Sequential Expression of Phenotype Markers for Osteoclasts during Differentiation of Precursors for Multinucleated Cells Formed in Long Term Human Marrow Cultures*

1990 • 63 citations

Neutrophil defect associated with malignant infantile osteopetrosis.

1986 • 55 citations

Cytoskeleton rearrangements during calcitonin-induced changes in osteoclast motility in vitro

1985 • 55 citations

Characterization of isolated and cultured chick osteoclasts: The effects of acetazolamide, calcitonin, and parathyroid hormone on acid production

1988 • 54 citations

Optimal bone resorption by isolated rat osteoclasts requires chloride bicarbonate exchange

1989 • 53 citations

1 alpha,25-dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II in nonerythroid avian bone marrow cells.

1990 • 53 citations

The distribution of 215-kilodalton mannose 6-phosphate receptors within cis (heavy) and trans (light) Golgi subfractions varies in different cell types.

1987 • 52 citations

Calcitonin, prostaglandin E2, and dibutyryl cyclic adenosine 3',5'-monophosphate disperse the specific microfilament structure in resorbing osteoclasts.

1990 • 52 citations

Motility and resorption: Osteoclastic activity in vitro

1984 • 51 citations

Immunocytochemical localization of a tartrate-resistant and vanadate-sensitive acid nucleotide tri- and diphosphatase.

1986 • 48 citations

Voltage-activated K+ conductances in freshly isolated embryonic chicken osteoclasts.

1989 • 45 citations

Na⁺/H⁺ antiporter is the primary proton transport system used by osteoclasts during bone resorption

1990 • 42 citations

Characterization of a Ca2+-ATPase in osteoclast plasma membrane

1990 • 42 citations

The effect of fluoride on the patterns of adherence of osteoclasts cultured on and resorbing dentine: a 3-D assessment of vinculin-labelled cells using confocal optical microscopy

1989 • 42 citations

“Calcium receptors” on eukaryotic cells with special reference to the osteoclast

1990 • 41 citations

K+ and Cl? currents in freshly isolated rat osteoclasts

1991 • 40 citations

Giant-Ceil Centrioles

1967 • 39 citations

Isolation of osteoclasts by velocity sedimentation at unit gravity

1977 • 34 citations

Characterization of the cytoskeleton of isolated chick osteoclasts: effect of calcitonin.

1989 • 34 citations

Direct effects of platelet-activating factor on isolated rat osteoclasts. Rapid elevation of intracellular free calcium and transient retraction of pseudopods

1991 • 31 citations

Identification of plasminogen activator in osteoclasts

1990 • 30 citations

Receptor‐mediated uptake of a mannose‐6‐phosphate bearing glycoprotein by isolated chicken osteoclasts

1988 • 30 citations

Inhibitory Actions of Calcitonin on Resorbing Bone Explants in Culture and on their Release of Lysosomal Hydrolases

1972 • 30 citations

Coexistence of reduced function of natural killer cells and osteoclasts in two distinct osteopetrotic mutations in the rat

1991 • 17 citations

Three voltage-activated K+ conductances and an ATP-activated conductance in freshly isolated embryonic chick osteoclasts

1989 • 9 citations

Lysozyme synthesis in osteoclasts

1990 • 9 citations

Characterization of an osteoclast membrane protein related to superoxide dismutase

1990 • 6 citations

Reply

1991 • 4 citations

Evidence for the presence of (pro)collagenase in osteoclasts

1992 • 4 citations

Deleted Work

1955 • 0 citations