Autocrine/paracrine regulation of apoptosis in epithelial cells by prostaglandin E2

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

1999 • 990 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

Cyclooxygenase-2 expression in human esophageal carcinoma.

1999 • 670 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma

2000 • 535 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Inhibition of Cyclooxygenase-2 Gene Expression by p53

1999 • 352 citations

Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2

1999 • 295 citations

Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder.

1999 • 289 citations

Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase

1997 • 263 citations

Induction of COX‐2 and PGE₂ biosynthesis by IL‐1β is mediated by PKC and mitogen‐activated protein kinases in murine astrocytes

2000 • 203 citations

Segregated Coupling of Phospholipases A2, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages

1998 • 179 citations

Molecular Modeling Studies of the DNA−Topoisomerase I Ternary Cleavable Complex with Camptothecin

1998 • 170 citations

Concordant Induction of Prostaglandin E2Synthase with Cyclooxygenase-2 Leads to Preferred Production of Prostaglandin E2over Thromboxane and Prostaglandin D2in Lipopolysaccharide-Stimulated Rat Peritoneal Macrophages

1997 • 149 citations

Cyclooxygenase-2 Expression and Prostaglandin E₂Synthesis Are Up-Regulated in Carcinomas of the Cervix: A Possible Autocrine/Paracrine Regulation of Neoplastic Cell Function via EP2/EP4 Receptors

2001 • 148 citations

Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems.

1994 • 130 citations

cDNA cloning, expression and characterization of human prostaglandin F synthase¹

1999 • 127 citations

Interleukin‐1 Stimulates Human Uterine Prostaglandin Production Through Induction of Cyclooxygenase‐2 Expression

2000 • 118 citations

Human glutathione dependent prostaglandin E synthase: gene structure and regulation

2000 • 117 citations

Molecular cloning of human platelet thromboxane a synthase

1991 • 116 citations

Molecular Cloning and Expression of Human Prostacyclin Synthase

1994 • 111 citations

Interleukin‐1β Induces Cyclooxygenase‐2 and Prostaglandin E₂ Synthesis in Human Neuroblastoma Cells

2000 • 101 citations

Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey.

1999 • 95 citations

The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells

2000 • 71 citations

Interleukin-1 receptor antagonist blocks interleukin-1– induced expression of cyclooxygenase-2 in endometrium

1997 • 56 citations

Measurement of PGE2 as the methyl oxime by radioimmunoassay using a novel lodinated label

1989 • 56 citations

Co-expression of Prostaglandin Receptors with Opposite Effects

1998 • 39 citations

Cyclooxygenase-2 Expression and Prostaglandin E2 Synthesis Are Up-Regulated in Carcinomas of the Cervix: A Possible Autocrine/Paracrine Regulation of Neoplastic Cell Function via EP2/EP4 Receptors

2001 • 36 citations

Interleukin-1β Induces Cyclooxygenase-2 in Cultured Human Decidual Cells

1995 • 30 citations