Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators.

2000 • 2,085 citations

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

1995 • 1,277 citations

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

1999 • 848 citations

Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

2001 • 801 citations

Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy

1997 • 774 citations

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1997 • 701 citations

Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

2003 • 633 citations

Expression of Advanced Glycation End Products and Their Cellular Receptor RAGE in Diabetic Nephropathy and Nondiabetic Renal Disease

2000 • 468 citations

Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy

2001 • 378 citations

Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure

1994 • 374 citations

Role of Advanced Glycation End Products in Diabetic Nephropathy

2003 • 344 citations

Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-κB Transcriptional Activation and Cytokine Secretion

2001 • 327 citations

Chelating Activity of Advanced Glycation End-product Inhibitors

2001 • 311 citations

Maillard Reaction-Mediated Molecular Damage to Extracellular Matrix and Other Tissue Proteins in Diabetes, Aging, and Uremia

1992 • 309 citations

Advanced glycation end products: A nephrologist's perspective

2000 • 293 citations

Angiotensin II Receptor Antagonists and Angiotensin-Converting Enzyme Inhibitors Lower In Vitro the Formation of Advanced Glycation End Products

2002 • 285 citations

Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy

2002 • 284 citations

Immunohistochemical Evidence for an Increased Oxidative Stress and Carbonyl Modification of Proteins in Diabetic Glomerular Lesions

1999 • 256 citations

Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE-peptides by renal proximal tubular cells

1996 • 248 citations

Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients.

1997 • 190 citations

Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.

1999 • 184 citations

Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes

2003 • 184 citations

Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model

2003 • 173 citations

Renoprotective effects of a novel inhibitor of advanced glycation

2001 • 165 citations

Advanced glycation end products and the progressive course of renal disease

2001 • 160 citations

Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment

1996 • 160 citations

Mechanisms for the formation of glycoxidation products in end-stage renal disease

2000 • 154 citations

Activation of Tubular Epithelial Cells in Diabetic Nephropathy

2002 • 152 citations

Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway

2004 • 148 citations

Regeneration of the Heart in Diabetes by Selective Copper Chelation

2004 • 146 citations

Long-term ACE Inhibition Doubles Lifespan of Hypertensive Rats

1997 • 126 citations

Determination of Nϵ-carboxymethyllysine in milk products by a modified reversed-phase HPLC method

1999 • 125 citations

ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic (mREN-2)27 Rat

2002 • 105 citations

Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function

2001 • 100 citations

The meaning of serum levels of advanced glycosylation end products in diabetic nephropathy

2000 • 92 citations

Protein Aging by Carboxymethylation of Lysines Generates Sites for Divalent Metal and Redox Active Copper Binding: Relevance to Diseases of Glycoxidative Stress

1999 • 86 citations

Renoprotective effects of vasopeptidase inhibition in an experimental model of diabetic nephropathy

2003 • 64 citations

Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats

2003 • 58 citations

Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats

2002 • 52 citations

Effects of a diet rich in advanced glycation end products in the rat remnant kidney model

2003 • 47 citations

Chemistry and Pathobiology of Advanced Glycation End Products

2000 • 41 citations

The vasopeptidase inhibitor AVE7688 ameliorates Type 2 diabetic nephropathy

2004 • 39 citations

Carbonyl Stress: Increased Carbonyl Modification of Tissue and Cellular Proteins in Uremia

1999 • 27 citations

Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats

2003 • 23 citations

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