Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients.

Beyond Cholesterol

1989 • 6,533 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix

1989 • 1,056 citations

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

1994 • 673 citations

Accelerated age-related browning of human collagen in diabetes mellitus.

1984 • 671 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

1991 • 534 citations

N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins

1995 • 518 citations

Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.

1994 • 473 citations

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

1994 • 463 citations

beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.

1993 • 405 citations

Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat

1991 • 395 citations

Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure

1994 • 374 citations

Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging.

1990 • 370 citations

Mechanistic Studies of Advanced Glycosylation End Product Inhibition by Aminoguanidine

1992 • 341 citations

Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.

1994 • 335 citations

Non-enzymatic glycosylation and the chronic complications of diabetes: an overview

1984 • 312 citations

Aging of Proteins: Immunological Detection of a Glucose-derived Pyrrole Formed during Maillard Reaction in vivo

1989 • 302 citations

Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal antibody.

1995 • 291 citations

Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.

1993 • 286 citations

Hemoglobin-AGE: A Circulating Marker of Advanced Glycosylation

1992 • 255 citations

Immunochemical evidence for the presence of advanced glycation end products in human lens proteins and its positive correlation with aging.

1992 • 250 citations

Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

1995 • 241 citations

Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline.

1992 • 218 citations

Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.

1992 • 215 citations

Identification of Fructose 3-Phosphate in the Lens of Diabetic Rats

1990 • 208 citations

Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein

1985 • 203 citations

Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy

1995 • 145 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Crosslines A and B as candidates for the fluorophores in age- and diabetes-related cross-linked proteins, and their diacetates produced by Maillard reaction of α-N-acetyl-<scp>L</scp>-lysine with<scp>D</scp>-glucose

1992 • 98 citations

Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine

1992 • 95 citations

Modification of β2m with advanced glycation end products as observed in dialysis-related amyloidosis by 3-DG accumulating in uremic serum

1996 • 82 citations

Nonenzymatic glycosylation products on collagen covalently trap low-density lipoprotein

1985 • 77 citations

Polymerization of proteins caused by reaction with sugars and the formation of 3-deoxyglucosone under physiological conditions.

1988 • 69 citations

Novel Imidazolone Compound Formed by the Advanced Maillard Reaction of 3-Deoxyglucosone and Arginine Residues in Proteins

1994 • 67 citations

3-Deoxyglucosone crosslinks proteins under physiological conditions.

1987 • 67 citations

Amyloid β2-microglobulin is modified with Nε-(carboxymethyl)lysine in dialysis-related amyloidosis

1996 • 66 citations

Presence of 3-Deoxyglucosone, a Potent Protein Crosslinking Intermediate of Maillard Reaction, in Diabetic Serum

1993 • 62 citations

Responsibility of 3-deoxyglucosone for the glucose-induced polymerization of proteins.

1987 • 54 citations

Elevated Serum Levels of 3-Deoxyglucosone, a Potent Protein-Cross-Linking Intermediate of the Maillard Reaction, in Uremic Patients

1995 • 53 citations

Immunohistochemical detection of advanced glycation end products in dialysis-related amyloidosis

1995 • 51 citations

Identification of the Modified Structure of Arginine Residues in Proteins with 3-Deoxyglucosone, a Maillard Reaction Intermediate

1995 • 45 citations

Chemical Studies on Amino-Carbonyl Reaction

1967 • 25 citations

Ligand-independent internalization and recycling of the insulin receptor. Effects of chronic treatment of 3T3-C2 fibroblasts with insulin and dexamethasone.

1992 • 22 citations

Immunochemical Detection of Carboxymethylated Apo B-100 in Copper-Oxidized LDL

1996 • 19 citations

Chemical Studies on Amino––Carbonyl Reaction

1962 • 14 citations

3-Deoxyglucosone Crosslinks Proteins under Physiological Conditions

1987 • 9 citations

Polymerization of Proteins Caused by Reaction with Sugars and the Formation of 3-Deoxyglucosone under Physiological Conditions

1988 • 6 citations

Responsibility of 3-Deoxyglucosone for the Glucose-Induced Polymerization of Proteins

1987 • 4 citations