Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease

1999 • 777 citations

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

1995 • 612 citations

Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease

2001 • 572 citations

A SIMPLE AND EFFICIENT METHOD FOR PURIFICATION OF INFECTIOUS RECOMBINANT ADENOVIRUS

1994 • 445 citations

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.

1995 • 333 citations

Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone.

1995 • 309 citations

Cell Biology of Synaptic Plasticity

1984 • 275 citations

Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl- <scp>l</scp> - carnitine and/or R -α-lipoic acid

2002 • 274 citations

β-Amyloid protein-induced Alzheimer's disease animal model

1994 • 264 citations

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models

1998 • 257 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Synapse loss in the temporal lobe in Alzheimer's disease

1993 • 247 citations

AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat

1984 • 213 citations

A new continuous alternation task in T-maze detects hippocampal dysfunction in mice

1998 • 190 citations

Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele

1996 • 189 citations

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

2000 • 184 citations

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

1995 • 183 citations

Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys

2001 • 181 citations

Dicistronic transcription units for gene expression in mammalian cells

1993 • 179 citations

Regular review: Uses of botulinum toxin injection in medicine today

2000 • 169 citations

Separation, purification, partial characterization and comparison of the heavy and light chains of botulinum neurotoxin types A, B, and E.

1985 • 161 citations

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

1995 • 146 citations

Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb‐Williams maze task

2002 • 143 citations

Perforated axospinous synapses with multiple, completely partitioned transmission zones: Probable structural intermediates in synaptic plasticity

1993 • 135 citations

Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses

1992 • 120 citations

Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat

1999 • 108 citations

Rescue and Regrowth of Sensory Nerves Following Deafferentation by Neurotrophic Factors

1999 • 107 citations

A 1-year controlled trial of acetyl- <scp>l</scp> -carnitine in early-onset AD

2000 • 104 citations

Activity‐dependent formation of perforated synapses in cultured hippocampal neurons

1999 • 95 citations

Differential Involvement of Synaptic Vesicle and Presynaptic Plasma Membrane Proteins in Alzheimer's Disease

1997 • 87 citations

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

1993 • 80 citations

Perirhinal cortex lesions in rats disrupt performance in a spatial DNMS task

1994 • 79 citations

The role of the entorhinal cortex in two forms of spatial learning and memory

2001 • 79 citations

Entorhinal cortex disruption causes memory deficit in early Alzheimer's disease as shown by PET

2001 • 77 citations

Acetyl-l-carnitine enhances Na+, K+-ATPase glutathione-s-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions

2001 • 69 citations

Longitudinal study on age-related changes of working and reference memory in the rat

1991 • 69 citations

Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats

2001 • 69 citations

Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.

1999 • 69 citations

Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human Apolipoprotein E4 transgenic mice

2000 • 64 citations

Tetanus toxin-induced seizures in infant rats and their effects on hippocampal excitability in adulthood

1995 • 59 citations

Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia

1998 • 57 citations

Acetyl-l-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats

1994 • 54 citations

Enhanced expression of AMPA receptor protein at perforated axospinous synapses

1998 • 53 citations

Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia

1997 • 52 citations

Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia

2001 • 51 citations

Effect of the mono- and tetra-sialogangliosides, GM1 and GQ1b, on long-term potentiation in the CA1 hippocampal neurons of the guinea pig

1998 • 48 citations

Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein‐repair enzyme‐deficient mice

2001 • 47 citations

Selective deposition of amyloid-? protein in the entorhinal-dentate projection of a transgenic mouse model of alzheimer's disease

1998 • 44 citations

Medical therapy and botulinum toxin in dystonia.

1998 • 41 citations

Cholinergic immunolesions by 192IgG‐saporin—a useful tool to simulate pathogenic aspects of alzheimer's disease

1997 • 39 citations

Effect of acetyl‐L‐carnitine on the dopaminergic system in aging brain

1991 • 36 citations

Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31P NMR spectroscopy.

2000 • 32 citations

Dietary carnitine supplements slow disease progression in a putative mouse model for hereditary ceroid-lipofuscinosis

1997 • 30 citations

Memory deficits in an experimental hippocampal epileptiform syndrome in rats

1982 • 29 citations

Acetyl-l-carnitine attenuates neuronal damage in gerbils with transient forebrain ischeia only when givenBefore the insult

1995 • 27 citations

Acetyl-L-Carnitine: Chronic Treatment Improves Spatial Acquisition in a New Environment in Aged Rats

1995 • 27 citations

Neuropathological Diagnosis of Sen1ile Dementia of the Alzheimer Type (SDAT): Proposal of Diagnostic Criteria and Report of the Japanese Research Meeting on Neuropathological Diagnosis of SDAT

1994 • 24 citations

Dynamic morphology of the synaptic junctional areas during aging: the effect of chronic acetyl-l-carnitine administration

1994 • 18 citations

The effect of l-carnitine on T-maze learning ability in aged rats

2001 • 17 citations

Toxins Affecting the Cholinergic System

1994 • 16 citations

Effects of levo-acetylcarnitine on second motoneuron survival after axotomy

1995 • 15 citations

Restoration of Decreased N-Methyl--asparate Receptor Activity by Brain-Derived Neurotrophic Factor in the Cultured Hippocampal Neurons: Involvement of cAMP

2001 • 11 citations

Acetylcholinesterase activity and post-lesional plasticity in the hippocampus of young and aged rats

1993 • 8 citations

Evidence That Synaptobrevin Is Involved in Fusion between Synaptic Vesicles and Synaptic Plasma Membrane Vesicles

1997 • 7 citations