Metabolism of the Newer Antidepressants

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Fluvoxamine

1986 • 493 citations

Newer antidepressants and the cytochrome P450 system

1996 • 488 citations

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

1992 • 456 citations

Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative

1986 • 382 citations

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1997 • 357 citations

Paroxetine

1991 • 328 citations

Clinical Pharmacokinetics of Fluoxetine

1994 • 314 citations

Pharmacokinetics of antidepressants: why and how they are relevant to treatment.

1993 • 269 citations

Inhibition by fluoxetine of cytochrome P450 2D6 activity

1993 • 259 citations

A review of the metabolism and pharmacokinetics of paroxetine in man

1989 • 259 citations

1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain

1989 • 229 citations

Sertraline

1992 • 227 citations

Venlafaxine oxidation in vitro is catalysed by CYP2D6

1996 • 226 citations

Serotonin-selective arylpiperazines with neuroendocrine, behavioral, temperature, and cardiovascular effects in humans.

1991 • 216 citations

Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms

1993 • 214 citations

Biochemical, neurophysiological, and behavioral effects of Wy‐45,233 and other identified metabolites of the antidepressant venlafaxine

1991 • 214 citations

Pharmacokinetic-Pharmacodynamic Relationship of the Selective Serotonin Reuptake Inhibitors???

1996 • 212 citations

The relationship between paroxetine and the sparteine oxidation polymorphism

1992 • 204 citations

Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A.

1989 • 195 citations

Citalopram

1991 • 193 citations

Antidepressants

1989 • 190 citations

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1993 • 189 citations

Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers

1988 • 182 citations

Inhibition of Alprazolam and Desipramine Hydroxylation In Vitro by Paroxetine and Fluvoxamine

1995 • 174 citations

The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans

1997 • 168 citations

A Double-Blind, Placebo-Controlled Study of Citalopram With and Without Lithium in the Treatment of Therapy-Resistant Depressive Patients

1996 • 168 citations

The Emerging Role of Cytochrome P450 3A in Psychopharmacology

1995 • 167 citations

Selective Serotonin Reuptake Inhibitors and CNS Drug Interactions

1997 • 167 citations

A Review of Functional Neuroimaging in Mood Disorders: Positron Emission Tomography and Depression

1997 • 166 citations

Inhibitors of imipramine metabolism by human liver microsomes.

1992 • 165 citations

Pharmacokinetics of Sertraline and its N-Demethyl Metabolite in Elderly and Young Male and Female Volunteers

1997 • 150 citations

Nefazodone

1997 • 141 citations

Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor

1997 • 140 citations

Therapeutic drug monitoring of tricyclic antidepressants.

1988 • 138 citations

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes.

1992 • 130 citations

Moclobemide

1992 • 130 citations

Analysis of Enantiomers of Citalopram and Its Demethylated Metabolites in Plasma of Depressive Patients Using Chiral Reverse-Phase Liquid Chromatography

1995 • 126 citations

Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes.

1997 • 126 citations

The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels

1980 • 126 citations

Mirtazapine

1996 • 125 citations

Tianeptine

1995 • 124 citations

Metabolic disposition of¹⁴C-venlafaxine in mouse, rat, dog, rhesus monkey and man

1993 • 120 citations

Desipramine Pharmacokinetics When Coadministered With Paroxetine or Sertraline in Extensive Metabolizers

1997 • 118 citations

Drug-Drug Interactions Involving Antidepressants: Focus on Venlafaxine

1996 • 116 citations

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part I.

1996 • 115 citations

Review of the animal pharmacology and pharmacokinetics of fluvoxamine.

1983 • 112 citations

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes

1997 • 109 citations

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin*

1996 • 109 citations

Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain

1993 • 107 citations

Phenacetin O -deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

1996 • 107 citations

Pharmacokinetics of the newer antidepressants: Clinical relevance

1994 • 104 citations

Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2

1997 • 103 citations

Clinical Pharmacokinetics of Nefazodone

1997 • 101 citations

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

1999 • 101 citations

Pharmacogenetics of antidepressants: clinical aspects

1997 • 100 citations

Pharmacokinetic drug interaction potential of selective serotonin reuptake inhibitors

1996 • 98 citations

Pharmacokinetics of milnacipran in comparison with other antidepressants

1996 • 98 citations

Importance of duration of drug action in the antagonism of p-chloroamphetamine depletion of brain serotonin—comparison of fluoxetine and chlorimipramine

1978 • 95 citations

Effect of cigarette smoking on fluvoxamine pharmacokinetics in humans

1995 • 92 citations

Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

1992 • 88 citations

Mirtazapine

1995 • 88 citations

Preclinical pharmacology of milnacipran

1996 • 86 citations

Rapid cycling depression in adolescence

1989 • 86 citations

Second Generation Antidepressants: A Comparative Review

1985 • 85 citations

Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.

1989 • 85 citations

Venlafaxine: A Structurally Unique and Novel Antidepressant

1995 • 84 citations

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

1992 • 84 citations

Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo*

1997 • 84 citations

Moclobemide

1996 • 81 citations

Mirtazapine: pharmacology in relation to adverse effects

1997 • 81 citations

Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma.

1994 • 81 citations

Serotonin Reuptake Blockers in Vitro and in Vivo

1987 • 80 citations

Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase.

1988 • 80 citations

In Vitro and In Vivo Studies on the Disposition of Mirtazapine in Humans

1997 • 76 citations

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

1993 • 75 citations

Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection

1992 • 74 citations

The effect of renal disease on the disposition of venlafaxine

1994 • 71 citations

Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone

1982 • 69 citations

Plasma levels of citalopram enantiomers and metabolites in elderly patients.

1997 • 68 citations

Drug Treatment of Depression in the 1990s

1996 • 68 citations

Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation

1996 • 67 citations

The α2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP)

1988 • 67 citations

Active Hydroxymetabolites of Antidepressants

1995 • 67 citations

Biotransformation of moclobemide in humans

1990 • 66 citations

Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: Analysis of interspecies variability and comparison with metabolismin vivo

1994 • 65 citations

The effect of sertraline on the pharmacokinetics of desipramine and imipramine

1997 • 64 citations

Antidepressants and drug‐metabolizing enzymes — expert group report

1996 • 64 citations

Formation of Active Metabolites of Psychotropic Drugs

1990 • 63 citations

Absorption and disposition of moclobemide in patients with advanced age or reduced liver or kidney function

1990 • 62 citations

The disposition of venlafaxine enantiomers in dogs, rats, and humans receiving venlafaxine

1992 • 62 citations

Clinical Pharmacokinetics of the Monoamine Oxidase-A Inhibitor Moclobemide*

1995 • 62 citations

Configurational studies on 2-[∝-(2-ethoxyphenoxy)benzyl] morpholine fce 20124

1985 • 60 citations

Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide*

1997 • 59 citations

Pharmacokinetic Optimisation of Therapy with Newer Antidepressants

1994 • 59 citations

Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding

1995 • 58 citations

Pharmacokinetic and Pharmacodynamic Evaluation of the Potential Drug Interaction Between Venlafaxine and Diazepam

1995 • 57 citations

Comparison of the Effects of Sertraline and Its Metabolite Desmethylsertraline on Blockade of Central 5-HT Reuptake In Vivo

1996 • 56 citations

Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans*

1997 • 54 citations

Inhibition of Trazodone Metabolism by Thioridazine in Humans

1995 • 54 citations

A Study of the Effect of Age and Gender on the Pharmacokinetics of Nefazodone After Single and Multiple Doses

1996 • 54 citations

1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants

1987 • 53 citations

Stereoselective and species‐dependent kinetics of reboxetine in mouse and rat

1995 • 52 citations

Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care.

1994 • 50 citations

Disposition kinetics of moclobemide, a monoamine oxidase-A enzyme inhibitor: Single and multiple dosing in normal subjects

1987 • 50 citations

Non‐linear fluvoxamine disposition

1998 • 50 citations

The Role of Metabolites of Antidepressants in the Treatment of Depression

1997 • 49 citations

The effects of single and repeated anorectic doses of 5‐hydroxytryptamine uptake inhibitors on indole levels in rat brain

1993 • 48 citations

Second-Generation Antidepressants

1984 • 47 citations

Selective Serotonin/Noradrenaline Reuptake Inhibitors (SNRIs)

1995 • 44 citations

Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O‐ and N‐demethylation

1996 • 42 citations

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs

1992 • 42 citations

Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan

1996 • 41 citations

Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man

1991 • 40 citations

Progress report on the anorectic effects of dexfenfluramine, fluoxetine and sertraline.

1992 • 39 citations

Daily administration ofm-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects

1996 • 38 citations

Are pharmacokinetic drug interactions with the SSRIs an issue?

1996 • 37 citations

Current Antidepressants

1986 • 37 citations

Therapeutic monitoring of antidepressant drugs: guidelines updated.

1989 • 35 citations

Clinical Pharmacokinetics 1990

1990 • 33 citations

Sertraline does not inhibit cytochrome P450 3A-mediated drug metabolism in vivo.

1997 • 30 citations

Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group.

1993 • 30 citations

Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment

1995 • 29 citations

Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450

1990 • 27 citations

Comparison of desmethylsertraline with sertraline as a monoamine uptake inhibitor in vivo

1995 • 27 citations

PHARMACOKINETICS OF REBOXETINE IN HEALTHY VOLUNTEERS. SINGLE AGAINST REPEATED ORAL DOSES AND LACK OF ENZYMATIC ALTERATIONS

1996 • 26 citations

The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers.

1990 • 26 citations

Selective Serotonin Reuptake Inhibitors in Older Patients

1997 • 25 citations

Disulfiram treatment of alcoholism. A Veterans Administration cooperative study

1987 • 25 citations

Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis

1995 • 24 citations

Detection of psychoactive drugs using19F MR spectroscopy

1995 • 23 citations

Clinical Pharmacokinetics of Oral Buspirone in Patients with Impaired Renal Function

1988 • 22 citations

Pharmacokinetics of the Antidepressant Tianeptine at Steady State in the Elderly

1991 • 22 citations

Disposition Kinetics of Moclobemide, a New Mao‐A Inhibitor, in Subjects with Impaired Renal Function

1990 • 21 citations

Species‐specific biotransformation of moclobemide: a comparative study in rats and humans

1990 • 20 citations

Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines

1989 • 20 citations

Antidepressants, Metabolites, and Apparent Drug Resistance

1990 • 20 citations

Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites

1992 • 18 citations

Kinetic profiles of tianeptine and its MC5 metabolite in plasma, blood and brain after single and chronic intraperitoneal administration in the rat

1990 • 17 citations

Tianeptine and its Main Metabolite

1989 • 17 citations

The paradox of tianeptine

1993 • 14 citations

Effects of the (+) and (−) Enantiomers of the Antidepressant Drug Tianeptine on 5-HTP-induced Behaviour

1997 • 12 citations

Steady-state pharmacokinetics of nefazodone in subjects with normal and impaired renal function

1995 • 12 citations

Brain Uptake and Acute Indole‐depleting Effect of Dexfenfluramine in Squirrel Monkeys after a High‐dose Regimen

1995 • 11 citations

Brofaromine

1995 • 11 citations

Interaction of nefazodone (N) and fluoxetine (F).

1996 • 10 citations

Pharmacokinetics and Bioavailability of Tianeptine in the Elderly

1990 • 8 citations

[Neurobiology of tianeptine. A new pharmaceutic agent].

1991 • 8 citations

Tianeptine and its main metabolite. Disposition in chronic renal failure and haemodialysis

1990 • 8 citations

[Antidepressive action, pharmacokinetic characteristics and biochemical properties of cimoxatone, a new reversible MAO-A inhibitor].

1983 • 7 citations

The Use of Pharmacokinetics in the Assessment of Dexfenfluramine Safety

1996 • 4 citations

Pharmacokinetic and pharmacodynamic drug interactions with polypharmacotherapy of treatment-resistant affective and obsessive-compulsive disorders.

1996 • 4 citations

Deleted Work

1955 • 0 citations